What is claimed is:
1. A prodrug for use in the treatment of physiological conditions comprising a carrier moiety selected from the group consisting essentially of cinnamoyl, benzoyl, phenylacetyl, 3,4-methylenedioxycinnamoyl and 3,4,5-trimethoxycinnamoyl, wherein the carrier moiety is chemically linked to a therapeutic pseudo-polypeptide having formula aan, where aa is a chemically modified amino acid or a chemical or structural variation thereof, where n is an integer from 2 to 40, and wherein the pseudo-polypeptide is poorly absorbed orally.
2. The prodrug of claim 1, wherein n is an integer from 20 to 40.
3. The prodrug of claim 1, wherein n is 30.
4. The prodrug of claim 1, wherein the prodrug further comprises a non-therapeutic linker species linking the polypeptide to the carrier moiety.
5. The prodrug of claim 4, wherein the non-therapeutic linker species is an amino acid.
6. A pharmaceutical composition comprising a carrier moiety selected from the group consisting essentially of cinnamoyl, benzoyl, phenylacetyl, 3,4 methylenedioxycinnamoyl and 3,4,5-trimethoxycinnamoyl chemically linked to a therapeutic pseudo-polypeptide having the formula aan, where aa is a chemically modified amino acid or a chemical or structural variation thereof, where n is an integer from 2 to 40, wherein the pseudo-polypeptide is poorly absorbed orally, and a pharmaceutically acceptable carrier.
7. A method for enhancing the oral availability of therapeutic pseudo-polypeptides having the formula formula aan, where aa is a chemically modified amino acid or a chemical or structural variation thereof, where n is an integer from 2 to 40, and wherein the pseudo-polypeptide is poorly absorbed orally, comprising the step of chemically linking the polypeptide to a carrier moiety selected from the group consisting essentially of cinnamoyl, benzoyl, phenylacetyl, 3,4-methylenedioxycinnamoyl and 3,4,5-trimethoxycinnamoyl to form a prodrug.
8. The method of claim 7, wherein the pseudo-polypeptide is chemically linked to the carrier moiety through a non-therapeutic linker species.
9. The method of claim 8, wherein the linker species is an amino acid.
10. A method for the treatment of a physiological condition through the oral administration of a therapeutically effective pseudo-polypeptide comprising the steps of:
(a) chemically linking a therapeutic pseudo-polypeptide having the formula aan, where aa is a chemically modified amino acid or a chemical or structural variation thereof, where n is an integer from 2 to 40, and wherein the pseudo-polypeptide is poorly absorbed orally, to a carrier moiety selected from the group consisting essentially of cinnamoyl, benzoyl, phenylacetyl, 3,4-methylenedioxycinnamoyl and 3,4,5-trimethoxycinnamoyl to form a prodrug; and
(b) orally administering the prodrug to a patient exhibiting the physiological condition.
11. The method of claim 10, wherein the pseudo-polypeptide is chemically linked to the carrier moiety through a non-therapeutic linker species.
12. The method of claim 11, wherein the linker species is an amino acid.
13. A method for the controlled release administration of a therapeutically effective pseudo-polypeptide having the formula aan, where aa is a chemically modified amino acid or a chemical or structural variation thereof, where n is an integer of from 2 to 40, and wherein the pseudo-polypeptide is poorly absorbed orally, comprising the steps of:
(a) chemically linking the pseudo-polypeptide to a carrier moiety selected from the group consisting essentially of cinnamoyl, benzoyl, phenylacetyl, 3,4-methylenedioxycinnamoyl and 3,4,5-trimethoxycinnamoyl to form a prodrug; and
(b) orally administering the prodrug to a patient.
14. The method of claim 13, wherein the polypeptide is chemically linked to the carrier moiety through a non-therapeutic linker species.
15. The method of claim 14, wherein the linker species is an amino acid.
16. A method for improving the immune response of a mammal against chronic and latent viral infections and malignant cells comprising the step of administration to the mammal a pharmaceutical composition according to claim 6.
17. The method of claim 16, wherein the route of administration is oral.
18. The method of claim 17, wherein the oral route of administration comprises administering the pharmaceutical composition in a solid oral dosage form.
19. The method of claim 16, wherein the route of administration is via injection.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A control method for air deflectors of an air conditioner, wherein, the air deflectors are arranged at an air outlet of the air conditioner and configured to adjust a direction of discharged air, the control method comprises following steps:
during the air conditioner is running in a refrigeration mode, judging whether a motion instruction for swinging air is input or not;
when the motion instruction for swinging air is not input, acquiring a set air volume level, set temperature T1 and indoor ambient temperature T2;
judging amount of refrigeration demand of a user according to the set air volume level, the set temperature T1 and the indoor ambient temperature T2; and
controlling an air guide angle of the air deflectors according to the amount of the refrigeration demand of the user.
2. The control method for air deflectors of an air conditioner according to claim 1, wherein, the step of judging amount of refrigeration demand of a user comprises:
judging whether the set air volume level is higher than a medium air volume level or not;
judging whether T1 is equal to or greater than T2+t, wherein, 1\u25a1\u2266t\u22663\u25a1;
if the set air volume level is higher than the medium air volume level, and T1\u2267T2+t, it is judged that the refrigeration demand of the user is large; otherwise, it is judged that the refrigeration demand of the user is small.
3. The control method for air deflectors of an air conditioner according to claim 2, wherein, an indoor fan of the air conditioner has options for air volume level, including a super-high air volume level, a high air volume level, the medium air volume level and a low air volume level; and the step of judging amount of refrigeration demand of a user comprises:
step a: judging whether the set air volume level is the super-high air volume level or not;
step b: if the set air volume level is the super-high air volume level, further judging whether T1 is equal to or greater than T2+t or not; if T1 is equal to or greater than T2+t, it is judged that the refrigeration demand of the user is large; if T1 is less than T2+t, it is judged that the refrigeration demand of the user is small;
step c: if the set air volume level is not the super-high air volume level, judging whether the set air volume level is the high air volume level or not;
step d: if the set air volume level is the high air volume level, further judging whether T1 is equal to or greater than T2+t; if T1 is equal to or greater than T2+t, it is judged that the refrigeration demand of the user is large; if T1 is less than T2+t, it is judged that the refrigeration demand of the user is small; and if the set air volume level is neither the super-high air volume level nor the high air volume level, it is judged that the refrigeration demand of the user is small.
4. The control method for air deflectors of an air conditioner according to claim 3, wherein, the step of controlling an air guide angle of the air deflectors according to the amount of the refrigeration demand of the user comprises:
when the set air volume level is the super-high air volume level, T1 is equal to or greater than T2+t, and it is judged that the refrigeration demand of the user is large, the air guide angle is adjusted to A;
when the set air volume level is the super-high air volume level, T1 is less than T2+t, and it is judged that the refrigeration demand of the user is small, the air guide angle is adjusted to a1;
when the set air volume level is the high air volume level, T1 is equal to or greater than T2+t, and it is judged that the refrigeration demand of the user is large, the air guide angle is adjusted to a2;
when the set air volume level is the high air volume level, T1 is less than T2+t, and it is judged that the refrigeration demand of the user is small, the air guide angle is adjusted to a3;
when the set air volume level is neither the super-high air volume level nor the high air volume level, and it is judged that the refrigeration demand of the user is small, the air guide angle is adjusted to a4;
wherein, a0=a2>a1>a3>a4.
5. The control method for air deflectors of an air conditioner according to claim 4, wherein, a0=a2=90\xb0.
6. The control method for air deflectors of an air conditioner according to claim 4, wherein, 20\xb0\u2266a1<90\xb0.
7. The control method for air deflectors of an air conditioner according to claim 4, wherein, 25\xb0\u2266a3<90\xb0.
8. The control method for air deflectors of an air conditioner according to claim 4, wherein, 30\xb0\u2266a4<90\xb0.
9. The control method for air deflectors of an air conditioner according to claim 1, wherein, the air deflectors are retractable along the direction of the air discharged from the air outlet, and the control method comprises following steps:
detecting the air guide angle of the air deflectors;
comparing the detected air guide angle \u03b1 with a set air guide angle \u03b1\u2032;
if a\u2267a\u2032, driving the air deflectors to extend outwards from an initial position for a stroke of X1;
if a<a\u2032, driving the air deflectors to extend outwards from an initial position for a stroke of X2;
wherein, X1<X2.
10. The control method for air deflectors of an air conditioner according to claim 9, wherein, 40\xb0\u2266a\u2032\u226650\xb0.
11. The control method for air deflectors of an air conditioner according to claim 9, wherein, 0 mm\u2266X1\u226620 mm.
12. The control method for air deflectors of an air conditioner according to claim 9, wherein, 20 mm\u2266X2\u226640 mm.
13. The control method for air deflectors of an air conditioner according to claim 1, wherein, the air conditioner is a pipe-ventilated air conditioner; and air is discharged downwards from the air outlet.
14. The control method for air deflectors of an air conditioner according to claim 2, wherein, the air deflectors are retractable along the direction of the air discharged from the air outlet, and the control method comprises following steps:
detecting the air guide angle of the air deflectors;
comparing the detected air guide angle \u03b1 with a set air guide angle \u03b1\u2032;
if a\u2267a\u2032, driving the air deflectors to extend outwards from an initial position for a stroke of X1;
if a<a\u2032, driving the air deflectors to extend outwards from an initial position for a stroke of X2;
wherein, X1<X2.
15. The control method for air deflectors of an air conditioner according to claim 14, wherein, 40\xb0\u2266a\u2032\u226650\xb0.
16. The control method for air deflectors of an air conditioner according to claim 14, wherein, 0 mm\u2266X1\u226620 mm.
17. The control method for air deflectors of an air conditioner according to claim 14, wherein, 20 mm\u2266X2\u226640 mm.
18. The control method for air deflectors of an air conditioner according to claim 3, wherein, the air deflectors are retractable along the direction of the air discharged from the air outlet, and the control method comprises following steps:
detecting the air guide angle of the air deflectors;
comparing the detected air guide angle \u03b1 with a set air guide angle \u03b1\u2032;
if a\u2267a\u2032, driving the air deflectors to extend outwards from an initial position for a stroke of X1;
if a<a\u2032, driving the air deflectors to extend outwards from an initial position for a stroke of X2;
wherein, X1<X2.
19. The control method for air deflectors of an air conditioner according to claim 18, wherein, 40\xb0\u2266a\u2032\u226650\xb0.
20. The control method for air deflectors of an air conditioner according to claim 18, wherein, 0 mm\u2266X1\u226620 mm.