1. A data transmission apparatus connected to a first transmission system and a second transmission system, the data transmission apparatus comprising
a key transmitting means for transmitting through the second transmission system decoding key information for decoding encoded data sent through the first transmission system,
generating means for adding first transmission control information to the data to be encoded and transmitted so as to generate transmitted data,
encoding means for generating encoded data from the transmitted data based on encoding key information corresponding to the decoding key information, and
data transmitting means for transmitting to the first transmission system the encoded data generated by the encoding means.
2. A data transmission apparatus as set forth in claim 1, wherein the communication capacity per unit time of the first transmission system is larger than the communication capacity per unit time of the second transmission system.
3. A data transmission apparatus as set forth in claim 2, wherein the first transmission system includes a satellite transmission line.
4. A data transmission apparatus as set forth in claim 3, wherein the second transmission system includes a cable transmission line.
5. A data transmission apparatus as set forth in claim 1, wherein the key transmitting means transmits destination information of the transmitted data along with the decoding key information through the second transmission system.
6. A data transmission apparatus as set forth in claim 5, wherein the key transmitting means transmits the same decoding key information and destination information to a plurality of receiving apparatuses connected to the first transmission line and the second transmission line.
7. A data transmission apparatus as set forth in claim 1, wherein the encoding means generates encoded data from the transmitted data based on the encoding key information and the destination information of the transmitted data.
8. A data transmission apparatus as set forth in claim 1, further comprising a key encoding means for encoding the work key information to generate decoding key information.
9. A data transmission apparatus as set forth in claim 8, wherein the encoding means generates encoded data from the transmitted data based on the work key information and the destination information of the transmitted data.
10. A data transmission apparatus as set forth in claim 1, wherein the first transmission control information includes the destination information of the transmitted data.
11. A data transmission apparatus as set forth in claim 10, wherein the first transmission control information includes an address defined by an Internet protocol as the destination information.
12. A data transmission apparatus as set forth in claim 10, wherein the encoding means encodes the transmitted data including the first transmission control information.
13. A data transmission apparatus as set forth in claim 10, wherein the encoding means adds to the transmitted data second transmission control information including the same destination information as the destination information included in the first transmission control information to generate the encoded data.
14. A data transmission apparatus as set forth in claim 13, wherein the encoding means adds a CRC check bit to generate the encoded data.
15. A data transmission apparatus as set forth in claim 13, wherein the second transmission control information includes information indicating the presence of coding of the data to be transmitted.
16. A data transmission apparatus as set forth in claim 15, wherein the second transmission control information includes information for distinguishing whether the data to be transmitted is information responding to a request from a receiving apparatus or whether it is control information for operating the communications system including the data transmitting apparatus.
17. A data transmitting apparatus connected to a first transmission system and a second transmission system, the data transmitting apparatus comprising
a key receiving means for receiving from the second transmission system encoding key information for encoding encoded data transmitted through the first transmission system,
a data generating means for adding control information to the data to be encoded and transmitted to generate transmitted data,
an encoding means for generating encoded data from the transmitted data based on the encoding key information, and
a data transmitting means for transmitting through the first transmission system the encoded data generated by the encoding means.
18. A data transmitting apparatus as set forth in claim 17, wherein the encoding means comprises key decoding means for decoding the encoding key information to generate work key information, and uses the work key information decoded by the key decoding means to generate encoded data.
19. A data transmitting apparatus as set forth in claim 18, wherein the encoding means generates encoded data based on the work key information and the destination information of the encoded data.
20. A data transmission method for transmitting data using a first transmission system and a second transmission system, the data transmission method comprising
a key transmitting step for transmitting through the second transmission system decoding key information for decoding encoded data transmitted through the first transmission system,
a data generating step for adding first transmission control information to the data to be encoded and transmitted to generate transmitted data,
an encoding step for generating encoded data from the generate transmitted data based on encoding key information corresponding to the decoding key information, and
a data transmitting step for transmitting the encoded data generated by the encoding step through the first transmission system.
21. A data transmission method as set forth in claim 20, wherein the communication capacity per unit time of the first transmission system is larger than the communication capacity per unit time of the second transmission system.
22. A data transmission method as set forth in claim 21, wherein the first transmission system includes a satellite transmission line.
23. A data transmission method as set forth in claim 21, wherein the second transmission system includes a cable transmission line.
24. A data transmission method as set forth in claim 20, wherein the key transmitting step transmits destination information of the transmitted data along with the decoding key information through the second transmission system.
25. A data transmission method as set forth in claim 24, wherein the key transmitting step transmits the same decoding key information and destination information to a plurality of receiving apparatuses connected to the first transmission line and the second transmission line.
26. A data transmission method as set forth in claim 20, wherein the encoding step generates encoded data from the transmitted data based on the encoding key information and the destination information of the transmitted data.
27. A data transmission method as set forth in claim 20, wherein further comprising a key encoding step for encoding the work key information to generate decoding key information.
28. A data transmission method as set forth in claim 27, wherein the encoding step generates encoded data from the transmitted data based on the work key information and the destination information of the transmitted data.
29. A data transmission method as set forth in claim 20, wherein the first transmission control information includes the destination information of the transmitted data.
30. A data transmission method as set forth in claim 29, wherein the first transmission control information includes an address defined by an Internet protocol as the destination information.
31. A data transmission method as set forth in claim 29, wherein the encoding step encodes the transmitted data including the first transmission control information.
32. A data transmission method as set forth in claim 29, wherein the encoding step adds to the transmitted data second transmission control information including the same destination information as the destination information included in the first transmission control information to generate the encoded data.
33. A data transmission method as set forth in claim 32, wherein the encoding step adds a CRC check bit to generate the encoded data.
34. A data transmission method as set forth in claim 32, wherein the second transmission control information includes information indicating the presence of coding of the data to be transmitted.
35. A data transmission method as set forth in claim 34, wherein the second transmission control information includes information for distinguishing whether the data to be transmitted is information responding to a request from a receiving apparatus or whether it is control information for operating the communications system including the data transmitting apparatus.
36. A data transmission method in a transmitting apparatus connected to a first transmission system and a second transmission system, the data transmission method comprising
a key receiving step for receiving from the second transmission system encoding key information for encoding encoded data transmitted through the first transmission system,
a data generating step for adding control information to the data to be encoded and transmitted to generate transmitted data,
an encoding step for generating encoded data from the transmitted data based on the encoding key information, and
a data transmitting step for transmitting through the first transmission system the encoded data generated by the encoding step.
37. A data transmission method as set forth in claim 36, wherein the encoding step includes a key decoding step for decoding the encoding key information to generate work key information, and uses the work key information decoded by the key decoding step to generate encoded data.
38. A data transmission method as set forth in claim 37, wherein the encoding step generates encoded data based on the work key Information and the destination information of the encoded data.
39. A data receiving apparatus connected to a first transmission system over which encoded data is transmitted and a second transmission system over which key information is transmitted, the data receiving apparatus comprising
a key receiving means for receiving from the second transmission system decoding key information for decoding encoded data received from the first transmission system,
a data receiving means for receiving the decoded data from the first transmission system,
a data restoring means for deleting first transmission control information from the encoded data, and
a decoding means for decoding the encoded data from which the first transmission control information was deleted based on the decoding key information to generate decoded data.
40. A data receiving apparatus as set forth in claim 39, wherein the communication capacity per unit time of the first transmission system is larger than the communication capacity per unit time of the second transmission system.
41. A data receiving apparatus as set forth in claim 40, wherein the first transmission system includes a satellite transmission line.
42. A data receiving apparatus as set forth in claim 40, wherein the second transmission system includes a cable transmission line.
43. A data receiving apparatus as set forth in claim 39, wherein the key receiving means receives destination information of the encoded data along with the decoding key information from the second transmission system.
44. A data receiving apparatus as set forth in claim 43, wherein a plurality of receiving apparatuses are connected to the first transmission system, and the key receiving means receives the same decoding key information and destination information as other receiving apparatuses connected to the first transmission line and the second transmission line.
45. A data receiving apparatus as set forth in claim 39, wherein the decoding means generates decoded data from the received data based on the decoding key information and the destination information of the encoded data.
46. A data receiving apparatus as set forth in claim 39, wherein the decoding means includes key decoding means for decoding the decoding key information to generate work key information, and uses the work key information generated by the key decoding means to decode the encoded data.
47. A data receiving apparatus as set forth in claim 46, wherein the decoding means decodes the encoded data based on the work key information and the destination information of the encoded data.
48. A data receiving apparatus as set forth in claim 39, wherein the first transmission control information includes the destination information of the encoded data.
49. A data receiving apparatus as set forth in claim 48, wherein the first transmission control information includes an address defined by an Internet protocol as the destination information.
50. A data receiving apparatus as set forth in claim 48, wherein the decoding means decodes the encoded data which was encoded including the first transmission control information.
51. A data receiving apparatus as set forth in claim 48, wherein further provision is made of a judgement means for judging if the encoded data is directed to itself based on the second transmission control information including the same destination information as the destination information included in the first transmission control information of the encoded data.
52. A data receiving apparatus as set forth in claim 51, wherein the judgement means judges if the encoded data is directed to itself and checks to the CRC check bit added to the encoded data to check for errors.
53. A data receiving apparatus as set forth in claim 51, wherein the judgement means judges if the encoded data is directed to itself and decides whether to decode or not based on the information indicating the presence of encoding included in the second transmission control information.
54. A data receiving apparatus as set forth in claim 53, wherein the second transmission control information includes information for distinguishing whether the received data is information responding to a request from its own receiving apparatus or whether it is control information for operating the communications system including the receiving apparatus.
55. A data receiving apparatus connected to a first transmission system and a second transmission system, the data receiving apparatus comprising
a key transmitting means for transmitting through the second transmission system encoding key information for preparing encoded data received from the first transmission system,
a data receiving means for receiving the encoded data encoded based on the encoding key information from the first transmission system,
a data restoring means for deleting the first transmission control information from the encoded data, and
a decoding means for decoding the encoded data based on decoding key information corresponding to the encoding key information.
56. A data receiving apparatus as set forth in claim 55, further comprising a key encoding means for encoding work key information to generate encoding key information.
57. A data receiving apparatus as set forth in claim 56, wherein the decoding means comprises a decoding key generating means for generating a decoding key based on the work key information and the destination information of the encoded data, and decodes the encoded data based on the decoding key generated by the decoding key generating means.
58. A data receiving method in a receiving apparatus connected to a first transmission system and a second transmission system, the data receiving method comprising
a key receiving step for receiving from the second transmission system decoding key information for decoding encoded data received from the first transmission system,
a data receiving step for receiving the decoded data from the first transmission system,
a data restoring step for deleting first transmission control information from the encoded data, and
a decoding step for decoding the encoded data from which the first transmission control information was deleted based on the decoding key information to generate decoded data.
59. A data receiving method as set forth in claim 58, wherein the communication capacity per unit time of the first transmission system is larger than the communication capacity per unit time of the second transmission system.
60. A data receiving method as set forth in claim 59, wherein the first transmission system includes a satellite transmission line.
61. A data receiving method as set forth in claim 59, wherein the second transmission system includes a cable transmission line.
62. A data receiving method as set forth in claim 58, wherein the key receiving step receives the destination information of the encoded data along with the decoded data from the second transmission system.
63. A data receiving method as set forth in claim 62, wherein the key receiving step receives the same decoding key information and destination information as other receiving apparatuses connected to the first transmission system and the second transmission system.
64. A data receiving method as set forth in claim 58, wherein the decoding step generates decoded data from the encoded data based on the decoding key information and the destination information of the encoded data.
65. A data receiving method as set forth in claim 58, wherein the decoding step includes key decoding step for decoding the decoding key information to generate work key information, and uses the work key information generated by the key decoding step to decode the encoded data.
66. A data receiving method as set forth in claim 65, wherein the decoding step decodes the encoded data based on the work key information and the destination information of the encoded data.
67. A data receiving method as set forth in claim 58, wherein the first transmission control information includes the destination information of the encoded data.
68. A data receiving method as set forth in claim 67, wherein the first transmission control information includes an address defined by an Internet protocol as the destination information.
69. A data receiving method as set forth in claim 67, wherein the decoding step decodes the encoded data which was encoded including the first transmission control information.
70. A data receiving method as set forth in claim 67, wherein further comprising a judgement step for judging if the encoded data is directed to itself based on the second transmission control information including the same destination information as the destination information included in the first transmission control information of the encoded data.
71. A data receiving method as set forth in claim 70, wherein the judgement step judges if the encoded data is directed to itself and checks to the CRC check bit added to the encoded data to check for errors.
72. A data receiving method as set forth in claim 70, wherein the judgement step judges if the encoded data is directed to itself and decides whether to decode or not based on the information indicating the presence of encoding included in the second transmission control information.
73. A data receiving method as set forth in claim 72, wherein the second transmission control information includes information for distinguishing whether the received data is information responding to a request from its own receiving apparatus or whether it is control information for operating the communications system including the receiving apparatus.
74. A data receiving method in a receiving apparatus connected to a first transmission system and a second transmission system, the data receiving method comprising
a key transmitting step for transmitting through the second transmission system encoding key information for preparing encoded data received from the first transmission system,
a data receiving step for receiving the encoded data encoded based on the encoding key information from the first transmission system,
a data restoring step for deleting the first transmission control information from the encoded data, and
a decoding step for decoding the encoded data based on decoding key information corresponding to the encoding key information.
75. A data receiving method as set forth in claim 74, wherein further provision is made of a key encoding step for encoding work key information to generate encoding key information.
76. A data receiving method as set forth in claim 75, wherein the decoding includes a decoding key generating step for generating decoding key information based on the work key information and the destination information of the encoded data, and decodes the encoded data based on the decoding key generated by the decoding key generating step.
77. A data transmission apparatus having a first transmission system and a second transmission system, the data transmission apparatus comprising:
a transmitting apparatus having
a key transmitting means for transmitting through the second transmission system decoding key information for decoding the encoded data transmitted through the first transmission system,
a data generating means for generating transmitted data added with first transmission control information from the data to be encoded and transmitted,
an encoding means for generating encoded data from the transmitted data based on encoding key information corresponding to the decoding key information, and
a data transmitting means for transmitting through the first transmission system the encoded data generated by the encoding means and
a receiving apparatus having
a key receiving means for receiving from the second transmission system decoding key information for decoding the encoded data received from the first transmission system,
a data receiving means for receiving the encoded data from the first transmission system, data restoring means for deleting first transmission control information from the encoded data, and
a decoding means for decoding the encoded data based on the decoding key information.
78. A data transmission apparatus having a first transmission system and a second transmission system, the data transmission apparatus comprising:
a transmitting apparatus having
a key receiving means for receiving from the second transmission system encoding key information for encoding the encoded data transmitted through the first transmission system,
a data generating means for generating transmitted data added with control information from the data to be encoded and transmitted,
an encoding means for generating encoded data from the transmitted data based on encoding key information, and
a data transmitting means for transmitting through the first transmission system the encoded data generated by the encoding means and
a receiving apparatus having
a key transmitting means for transmitting through the second transmission system encoding key information for preparing the encoded data received from the first transmission system,
a data receiving means for receiving the encoded data encoded based on the encoding key information from the first transmission system,
a data restoring means for deleting first transmission control information from the encoded data, and
a decoding means for decoding the encoded data based on decoding key information corresponding to the encoding key information.
79. A data transmission method using a transmission apparatus having a first transmission system and a second transmission system, the data transmission method comprising:
a transmitting processing step having
a key transmitting step for transmitting through the second transmission system decoding key information for decoding the encoded data transmitted through the first transmission system,
a data generating step for generating transmitted data added with first transmission control information from the data to be encoded and transmitted,
an encoding step for generating encoded data from the transmitted data based on encoding key information corresponding to the decoding key information, and
a data transmitting step for transmitting through the first transmission system the encoded data generated by the encoding step and
a receiving processing step having
a key receiving step for receiving from the second transmission system decoding key information for decoding the encoded data received from the first transmission system,
a data receiving step for receiving the encoded data from the first transmission system,
a data restoring step for deleting first transmission control information from the encoded data, and
a decoding step for decoding the encoded data based on the decoding key information.
80. A data transmission method for transmission of data using a transmission apparatus having a first transmission system and a second transmission system, the data transmission method comprising:
a transmitting processing step having
a key receiving step for receiving from the second transmission system encoding key information for encoding the encoded data transmitted through the first transmission system,
a data generating step for generating transmitted data added with control information from the data to be encoded and transmitted,
an encoding step for generating encoded data from the transmitted data based on encoding key information, and
a data transmitting step for transmitting through the first transmission system the encoded data generated by the encoding step and
a receiving processing step having
a key transmitting step for transmitting through the second transmission system encoding key information for preparing the encoded data received from the first transmission system,
a data receiving step for receiving the encoded data encoded based on the encoding key information from the first transmission system,
a data restoring step for deleting first transmission control information from the encoded data, and
a decoding step for decoding the encoded data based on decoding key information corresponding to the encoding key information.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. Vaccine comprising at least one mRNA encoding at least one antigen for use in the prophylaxis andor treatment of a disease in newborns andor infants, exhibiting an age of not more than 2 years, wherein the treatment comprises vaccination of the newborn or infant and eliciting an immune response in said newborn or infant.
2. Vaccine for use according to claim 1, wherein eliciting an immune response in a patient comprises eliciting a Th1 immune response.
3. Vaccine for use according to claim 1, wherein the newborns or infants is male or female, a mammal, a human andor exhibits an age of not more than 3 years of not more than 2 years, of not more than 1.5 years, of not more than 1 year (12 months), of not more than 9 months, 6 months or 3 months.
4. Vaccine for use according to claim 1, wherein the disease is selected from infectious diseases, viral, bacterial or protozoological infectious diseases, autoimmune diseases, allergies or allergic diseases or cancer or tumour diseases.
5. Vaccine for use according to claim 1, wherein the antigen is selected from protein and peptide antigens, tumour antigens, self-antigens or auto-antigens, auto-immune self-antigens, pathogenic antigens, viral antigens, bacterial antigens, fungal antigens, protozoological antigens, animal antigens, allergy antigens.
6. Vaccine for use according to claim 1, wherein the vaccine is to be administered parenterally, orally, nasally, pulmonary, by inhalation, topically, rectally, buccally, vaginally, or via an implanted reservoir.
7. Vaccine for use according to claim 1, wherein the at least one mRNA encoding at least one antigen is to be administered in its naked form or is associated with or complexed with a cationic or polycationic compound.
8. Vaccine for use according to claim 1, wherein the at least one mRNA encoding at least one antigen is complexed with a polymeric carrier formed by disulfide-crosslinked cationic components selected from
an oligopeptide having following sum formula (I):
{(Arg)l;(Lys)m;(His)n;(Orn)o;(Xaa)x};\u2003\u2003(formula (I)
wherein 1+m+n+o+x=3-100, and l, m, n or o independently of each other is any number selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21-30, 31-40, 41-50, 51-60, 61-70, 71-80, 81-90 and 91-100 provided that the overall content of Arg (Arginine), Lys (Lysine), His (Histidine) and Orn (Ornithine) represents at least 10% of all amino acids of the oligopeptide of formula (V); and Xaa is any amino acid selected from native (=naturally occurring) or non-native amino acids except of Arg, Lys, His or Orn; and x is any number selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21-30, 31-40, 41-50, 51-60, 61-70, 71-80, 81-90, provided, that the overall content of Xaa does not exceed 90% of all amino acids of the oligopeptide of formula (I),
or from a disulfide-crosslinked cationic component comprising as a repeat unit an oligopeptide having following subformula (Ia):
{(Arg)l;(Lys)m;(His)n;(Orn)o;(Xaa\u2032)x(Cys)y};\u2003\u2003formula (Ia)
wherein (Arg)l;(Lys)m;(His)n;(Orn)o; and x is preferably are as defined above for formula (I), Xaa\u2032 is any amino acid selected from native (=naturally occurring) or non-native amino acids except of Arg, Lys, His, Orn or Cys and y is any number selected from 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21-30, 31-40, 41-50, 51-60, 61-70, 71-80 and 81-90, provided that the overall content of Arg (Arginine), Lys (Lysine), His (Histidine) and Orn (Ornithine) represents at least 10% of all amino acids of the oligopeptide.
or from a disulfide-crosslinked cationic component comprising as a repeat unit an oligopeptide having following subformula (Ib):
Cys1{(Arg)l;(Lys)m;(His)n;(Orn)o;(Xaa)x}Cys2;\u2003\u2003(formula (Ib))
wherein component {(Arg)l;(Lys)m;(His)n;(Orn)o;(Xaa)x} (formula (I)) within formula (Ib) is as defined herein and forms a core of subformula (Ib), and wherein Cys1 and Cys2 are Cysteines proximal to, or terminal to (Arg)l;(Lys)m;(His)n;(Orn)o;(Xaa)x.
9. Vaccine for use according to claim 1, wherein the at least one mRNA encoding at least one antigen is complexed with a polymeric carrier according to generic formula (VI):
L-P1\u2014S\u2014S\u2014P2\u2014Sn\u2014S\u2014P3-L
wherein,
P1 and P3 are different or identical to each other and represent a linear or branched PZ hydrophilic polymer chain, each P1 and P3 exhibiting at least one \u2014SH-moiety, capable to form a disulfide linkage upon condensation with component P2, the linear or branched hydrophilic polymer chain selected independent from each other from polyethylene glycol (PEG), poly-N-(2-hydroxypropyl)methacrylamide, poly-2-(methacryloyloxy)ethyl phosphorylcholines, poly(hydroxyalkyl L-asparagine), poly(2-(methacryloyloxy)ethyl phosphorylcholine), hydroxyethylstarch or poly(hydroxyalkyl L-glutamine), wherein the hydrophilic polymer chain exhibits a molecular weight of about 1 kDa to about 100 kDa,
P2 is a cationic or polycationic peptide or protein, having a length of about 3 to about 100 amino acids, or
is a cationic or polycationic polymer, having a molecular weight of about 0.5 kDa to about 30 kDa,
each P2 exhibiting at least two \u2014SH-moieties, capable to form a disulfide linkage upon condensation with further components P2 or component(s) P1 andor P3;
\u2014S\u2014S\u2014 is a (reversible) disulfide bond;
L is an optional ligand, which may be present or not, and may be selected independent from the other from RGD, Transferrin, Folate, a signal peptide or signal sequence, a localization signal or sequence, a nuclear localization signal or sequence (NLS), an antibody, a cell penetrating peptide (CPP), TAT, KALA, a ligand of a receptor, cytokines, hormones, growth factors, small molecules, carbohydrates, mannose, galactose, synthetic ligands, small molecule agonists, inhibitors or antagonists of receptors, or RGD peptidomimetic analogues; and
n is an integer, selected from a range of about 1 to 50, preferably in a range of about 1, 2, 3, 4, or 5 to 10, more preferably in a range of about 1, 2, 3, or 4 to 9.
10. Vaccine for use according to claim 9, wherein the at least one mRNA encoding at least one antigen is complexed with a polymeric carrier molecule according to formula (VIa)
L-P1\u2014S\u2014{S\u2014P2\u2014SaS-(AA)x-Sb}\u2014S\u2014P3-L,
wherein S, L, P1, P2 and P3 are preferably as defined above for formula (VI),
a and b are integers, wherein a+b=n and n is an integer as defined above for formula (VI),
x is an integer selected from a range of about 1 to 100, and
(AA) is selected from an aromatic, a hydrophilic, a lipophilic, or a weak basic amino acid or peptide, or is a signal peptide or signal sequence, a localization signal or sequence, a nuclear localization signal or sequence (NLS), an antibody, a cell penetrating peptide (CPP), or is selected from therapeutically active proteins or peptides, from antigens, tumour antigens, pathogenic antigens, animal antigens, viral antigens, protozoan antigens, bacterial antigens, allergic antigens, autoimmune antigens, from allergens, from antibodies, from immunostimulatory proteins or peptides, or from antigen-specific T cell receptors.
11. Vaccine for use according to claim 1, wherein the vaccine is formulated to comprise a) an (adjuvant) component, comprising or consisting of at least one (m)RNA, complexed with a cationic or polycationic compound andor with a polymeric carrier as defined according to claim 7, and b) at least one free mRNA encoding an antigen, as defined according to claim 1.
12. Vaccine for use according to claim 11, wherein the (m)RNA is an mRNA as defined according to claim 1, an immunostimulatory nucleic acid, a CpG nucleic acid, a CpG-RNA, a CpG-DNA, or an immunostimulatory RNA (is RNA).
13. Vaccine for use according to claim 1, wherein the vaccine furthermore comprises a pharmaceutically acceptable carrier andor vehicle.
14. Vaccine for use according to claim 1, wherein the vaccine furthermore comprises at least one adjuvant, an auxiliary substance selected from lipopolysaccharides, TNF-alpha, CD40 ligand, or cytokines, monokines, lymphokines, interleukins or chemokines, IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12, IL-13, IL-14, IL-15, IL-16, IL-17, IL-18, IL-19, IL-20, IL-21, IL-22, IL-23, IL-24, IL-25, IL-26, IL-27, IL-28, IL-29, IL-30, IL-31, IL-32, IL-33, IFN\u03b1, IFN\u03b2, IFN\u03b3, GM-CSF, G-CSF, M-CSF, LT-beta, TNF-alpha, growth factors, and hGH, a ligand of human Toll-like receptor TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, a ligand of murine Toll-like receptor TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12 or TLR13, a ligand of a NOD-like receptor, a ligand of a RIG-I like receptor, an immunostimulatory nucleic acid, an immunostimulatory RNA (is RNA), a CpG-DNA, an anti-bacterial agent, or an anti-viral agent.
15. Kit, comprising a vaccine as defined according to claim 1, wherein each mRNA encoding at least one antigen is provided in a different part of the kit.
16. Vaccine for use according to claim 1, wherein the vaccine is formulated to comprise a) an (adjuvant) component, comprising or consisting of at least one (m)RNA, complexed with a cationic or polycationic compound andor with a polymeric carrier as defined according to claim 8, and b) at least one free mRNA encoding an antigen, as defined according to claim 1.
17. Vaccine for use according to claim 1, wherein the vaccine is formulated to comprise a) an (adjuvant) component, comprising or consisting of at least one (m)RNA, complexed with a cationic or polycationic compound andor with a polymeric carrier as defined according to claim 7, and b) at least one free mRNA encoding an antigen, as defined according to claim 5.
18. Vaccine for use according to claim 1, wherein the vaccine is formulated to comprise a) an (adjuvant) component, comprising or consisting of at least one (m)RNA, complexed with a cationic or polycationic compound andor with a polymeric carrier as defined according to claim 8, and b) at least one free mRNA encoding an antigen, as defined according to claim 5.
19. Vaccine for use according to claim 11, wherein the (m)RNA is an mRNA as defined according to claim 5, an immunostimulatory nucleic acid, a CpG nucleic acid, a CpG-RNA, a CpG-DNA, or an immunostimulatory RNA (is RNA).