What is claimed is:
1. A data processing apparatus comprising:
a program memory which stores an operation program comprised of a variety of instructions;
an external input terminal fed with a variety of data and a variety of signals from the outside;
a clock input terminal fed with a clock signal from the outside;
a data processing circuit for executing a variety of data processing in synchronization with the clock signal fed through said clock input terminal from the outside in accordance with a variety of data fed through said external input terminal from the outside and the operation program stored in said program memory;
an input monitor circuit for monitoring the variety of data and the variety of signals fed through said external input terminal from the outside to execute a predetermined counter-operation upon determining that the data or signals are improper;
an operation control circuit for controlling operations involved in temporarily stopping and restarting said input monitor circuit and said data processing circuit;
a clock counter circuit for counting the clock signal fed through said clock input terminal from the outside when said operation control circuit temporarily stops said input monitor circuit and said data processing circuit; and
a monitor start circuit for restarting said input monitor circuit temporarily stopped by said operation control circuit when a count number of said clock counter circuit reaches a predetermined number.
2. The data processing apparatus according to claim 1, wherein:
said monitor start circuit includes:
a register circuit in which a predetermined count number is set; and
a comparator circuit for comparing the count number set in said register circuit with the count number of said clock counter circuit.
3. The data processing apparatus according to claim 2, wherein said register circuit updatably stores the count number of the clock fed from the outside.
4. A data processing system comprising:
the data processing apparatus according to claim 1; and
a data processing terminal station for feeding the variety of data and the variety of signals to the external output terminal of said data processing apparatus and feeding the clock signal to the clock input terminal of said data processing apparatus.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound of formula (I):
or a pharmaceutically acceptable salt or stereoisomer thereof, wherein:
R1 is hydrogen or a C1-6alkyl;
R2 is (1) amino(CH2)2-6; (2) amino(CH2)1-6difluoromethyl(CH2)1-6; (3) amino(CH2)1-6fluoromethyl(CH2)1-6; (4) amino(CH2)0-6oxetanyl(CH2)1-6; (5) amino(CH2)1-6oxetanyl(CH2)0-6; or (6) pyrrolidin-3-yl, unsubstituted or 4-substituted by halogen; and
X is \u2014O\u2014, \u2014S\u2014, \u2014S(\u2550O)\u2014, \u2014S(O2)\u2014, \u2014CH2\u2014, \u2014CF2\u2014 or \u2014NH\u2014.
2. A compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein:
R1 is hydrogen or methyl;
R2 is
and
X is \u2014O\u2014, \u2014S\u2014, \u2014S(\u2550O)\u2014, \u2014S(O2)\u2014, \u2014CH2\u2014, \u2014CF2\u2014 or \u2014NH\u2014.
3. A compound according to claim 2, wherein R2 is
4. A compound according to claim 2, wherein R2 is
5. A compound according to claim 2, wherein R2 is
6. A compound according to claim 2, wherein R2 is
7. A compound according to claim 2, wherein R2 is
8. A compound according to claim 2, wherein R2 is
9. A compound according to claim 2, wherein R2 is
10. A compound according to claim 2, wherein R2 is
11. A compound according to claim 2, wherein R2 is
12. A compound according to claim 1, wherein X is \u2014S\u2014, \u2014S(\u2550O)\u2014 or \u2014S(O2)\u2014.
13. A compound according to claim 2, wherein X is \u2014S\u2014.
14. A compound according to claim 2, wherein X is \u2014S(\u2550O)\u2014.
15. A compound according claim 2, wherein X is \u2014S(O2)\u2014.
16. A compound according to claim 1, wherein:
R1 is hydrogen or methyl;
R2 is aminopropyl; aminomethyldifluoromethylmethyl; aminomethyloxetanyl or aminooxetanylmethyl; and
X is \u2014S\u2014, \u2014S(\u2550O)\u2014 or \u2014S(O2)\u2014.
17. A compound according to claim 1, selected from the group consisting of:
N-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)thieno3,2-dpyrimidin-4-yl-2,2-difluoropropane-1,3-diamine;
N-2-(1-oxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)thieno3,2-dpyrimidin-4-ylpropane-1,3-diamine;
N-2-(2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)thieno3,2-dpyrimidin-4-ylpropane-1,3-diamine;
N-2-(2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylthieno3,2-dpyrimidin-4-ylpropane-1,3-diamine;
N-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylthieno3,2-dpyrimidin-4-ylpropane-1,3-diamine;
N-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)thieno3,2-dpyrimidin-4-ylpropane-1,3-diamine;
N-(3-aminooxetan-3-yl)methyl-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)thieno3,2-dpyrimidin-4-amine;
N-3-(aminomethyl)oxetan-3-yl-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)thieno3,2-dpyrimidin-4-amine; and
N-(3-aminooxetan-3-yl)methyl-2-(1R)-1-oxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-ylthieno3,2-dpyrimidin-4-amine;
or a pharmaceutically acceptable salt thereof.
18. A compound according to claim 1, selected from the group consisting of:
N-(3-aminooxetan-3-yl)methyl-2-(1S)-1-oxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-ylthieno3,2-dpyrimidin-4-amine;
N-(3-aminooxetan-3-yl)methyl-6-methyl-2-(1-oxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)thieno3,2-dpyrimidin-4-amine;
2-fluoro-N-6-methyl-2-(1-oxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)thieno3,2-dpyrimidin-4-ylpropane-1,3-diamine;
N-6-methyl-2-(1-oxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)thieno3,2-dpyrimidin-4-ylethane-1,2-diamine;
N-{3-(aminomethyl)oxetan-3-ylmethyl}-6-methyl-2-(1-oxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)thieno3,2-dpyrimidin-4-amine;
N-6-methyl-2-(1-oxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)thieno3,2-dpyrimidin-4-ylpropane-1,3-diamine;
N-trans-(\xb1)-4-fluoropyrrolidin-3-yl-6-methyl-2-(1-oxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)thieno3,2-dpyrimidin-4-amine;
6-methyl-2-(1-oxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-N-(pyrrolidin-3-yl)thieno3,2-dpyrimidin-4-amine; and
N-6-methyl-2-(1,2,3,5-tetrahydro-4H-1,4-benzodiazepin-4-yl)thieno3,2-dpyrimidin-4-ylpropane-1,3-diamine;
or a pharmaceutically acceptable salt thereof.
19. A compound according to claim 1, selected from the group consisting of:
N-2-(1,2,3,5-tetrahydro-4H-1,4-benzodiazepin-4-yl)thieno3,2-dpyrimidin-4-ylpropane-1,3-diamine;
N-2-(2,3-dihydro-1,4-benzoxazepin-4(5H)-yl)thieno3,2-dpyrimidin-4-ylpropane-1,3-diamine;
N-2-(5,5-difluoro-1,3,4,5-tetrahydro-2H-2-benzazepin-2-yl)thieno3,2-dpyrimidin-4-ylpropane-1,3-diamine;
N-{3-(aminomethyl)oxetan-3-ylmethyl}-2-(5,5-difluoro-1,3,4,5-tetrahydro-2H-2-benzazepin-2-yl)thieno3,2-dpyrimidin-4-amine;
N-2-(1,3,4,5-tetrahydro-2H-2-benzazepin-2-yl)thieno3,2-dpyrimidin-4-ylpropane-1,3-diamine;
N-2-(2,3-dihydro-1,4-benzoxazepin-4(5H)-yl)-6-methylthieno3,2-dpyrimidin-4-ylpropane-1,3-diamine;
N-2-(5,5-difluoro-1,3,4,5-tetrahydro-2H-2-benzazepin-2-yl)-6-methylthieno3,2-dpyrimidin-4-ylpropane-1,3-diamine; and
N-6-methyl-2-(1,3,4,5-tetrahydro-2H-2-benzazepin-2-yl)thieno3,2-dpyrimidin-4-ylpropane-1,3-diamine;
or a pharmaceutically acceptable salt thereof.
20. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable excipient.