1. New compounds of formula (I),
wherein the meaning of R1 is hydrogen atom, C1-C5 acyl group, benzoyl group or R2\u2014COOR3 group, Y is hydrogen atom or alkali ion, R2 is C1-C4 straight or branched alkylidene group and R3 is hydrogen atom, C1-C4 alkyl group or alkali ion, andor stereoisomers andor diastereomers andor pharmaceutically acceptable salts andor hydrates andor solvates thereof.
2. (R,S)-2-4-(5-p-methylphenyl-3-trifluoro-methyl-pyrazol-1-yl)-benzenesulfonyl-aminooxy-propionic acid.
3. Disodium (R,S)-244-(5-p-methylphenyl-3-trifluoromethyl-pyrazol-1-yl)-benzenesulfonylaminooxy-propionic acid monohydrate.
4. A process for the synthesis of compounds of claims 1-3 andor geometric isomers andor stereoisomers andor diastereomers andor pharmaceutically acceptable salts andor hydrates andor solvates thereof, characterized by reacting 4,4,4-trifluoro-1-(4-methyl-6 phenyl)-butane-1,3-dione with p-hydrazino-benzenesulfonic acid in an inert solvent in the presence of hydrochloric acid, then reacting the obtained compound of formula (III) with phosphorus pentachloride in an inert solvent to give compound of formula (II), which is reacted
a) with hydroxylamine, or
b) with a compound of formula NH2-0-R2\u2014COOR3, wherein the meaning of R2 and R3 is the same as mentioned before, or
c) with a compound of formula NH2-000R1, wherein the meaning of R1 is the same as mentioned before to yield compounds of formula (I).
5. A pharmaceutical composition containing a compound of claims 1-3 andor stereoisomers andor diastereomers andor pharmaceutically acceptable salts andor hydrates andor solvates thereof as well as one or more pharmaceutically acceptable adjuvant andor auxiliary material.
6. Use of a compound of claims 1, 2, or 3 or stereoisomers or diastereomers or pharmaceutically acceptable salts or hydrates or solvates thereof for manufacturing a pharmaceutical composition for the treatment of inflammation and disorders associated with inflammation.
7. A method of treatment of inflammation and disorders associated with inflammation, characterized by administering to a mammal to be treated including human-effective amountamounts of a compound of claim 1, 2, or 3 or stereoisomers or diastereomers or pharmaceutically acceptable salts or hydrates or solvates thereof.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A printing system, comprising:
a storage device encoded with instructions; and
a processor that executes the instructions to:
print an image on continuous feed media via a printer;
compute a compensation factor that accounts for variation in form length of the continuous feed media;
compute, based on the compensation factor, a distance to advance the continuous feed media such that a succeeding print starts at a top of form location of the continuous feed media; and
cause the printer to advance the continuous feed media in accordance with the determined distance to advance such that the succeeding print starts at the top of form location of the continuous feed media.
2. The printing system of claim 1, wherein the processor executes the instructions to compute the compensation factor to account for error in continuous feed media advance distance of the printer, a top margin length enforced by the printer, and a bottom margin length enforced by the printer.
3. The printing system of claim 1, wherein the processor executes the instructions to compute the distance to advance such that the top of form location is always on an outer side of a fan fold form of the continuous feed media.
4. The printing system of claim 1, wherein the processor executes the instructions to compute a total length to advance the continuous feed media to the top of form location from a starting location of the image based on length of the image, and double form length of the continuous feed media adjusted using the compensation factor.
5. The printing system of claim 4, wherein the processor executes the instructions to compute the distance to advance the continuous feed media to the top of form location from an end location of the image as the total length less bottom margin length, top margin length, and the length of the image.
6. The printing system of claim 1, wherein the processor executes the instructions to compute the compensation factor based on an average sheet length of the continuous feed media computed based on a scale printed across form boundaries.
7. The printing system of claim 1, wherein the processor executes the instructions to:
print a scale across a form delimiter of the continuous media beyond an end location of the image on the continuous feed media as part of printing the image, and
adjust the correction factor based on a reading of the scale.
8. A method for printing, comprising:
printing, via a printer, an image on continuous feed media;
computing a compensation factor that accounts for variation in form length of the continuous feed media;
computing, based on the compensation factor, a distance to advance the continuous feed media such that a succeeding print starts at a top of form location of the continuous feed media; and
causing the printer to advance the continuous feed media in accordance with the determined distance to advance such that the succeeding print starts at the top of form location of the continuous feed media.
9. The method of claim 8, further comprising accounting for error in continuous feed media advance distance of the printer, a top margin length enforced by the printer, and a bottom margin length enforced by the printer in computing the compensation factor.
10. The method of claim 8, further comprising computing the distance to advance such that the top of form location is always on an outer side of a fan fold form of the continuous feed media.
11. The method of claim 8, further comprising computing a total length to advance the continuous feed media to the top of form location from a starting location of the image based on length of the image, and double form length of the continuous feed media adjusted using the compensation factor.
12. The method of claim 11, further comprising computing the distance to advance the continuous feed media to the top of form location from an end location of the image on the continuous feed media as the total length less bottom margin length, top margin length, and the length of the image.
13. The method of claim 8, further comprising:
computing an average form length for the continuous feed media based on scales printed across form boundaries; and
computing the compensation factor based on the average form length.
14. The method of claim 8, further comprising:
printing a scale across a form delimiter of the continuous media beyond the end of the image as part of printing the image; and
adjusting the correction factor based on a reading of the scale.
15. A computer-readable storage device encoded with instructions that when executed cause a processor to:
print, via a printer, an image on continuous feed media;
compute a compensation factor that accounts for variation in form length of the continuous feed media;
compute, based on the compensation factor, a distance to advance the continuous feed media such that a succeeding print starts at a top of form location of the continuous feed media; and
cause the printer to advance the continuous feed media in accordance with the determined distance to advance such that the succeeding print starts at the top of form location of the continuous feed media.
16. The computer-readable storage device of claim 15 encoded with instructions that when executed cause the processor to:
compute a total length to advance the continuous feed media to the top of form location from a starting location of the image based on length of the image, and double form length of the continuous feed media adjusted using the compensation factor; and
compute the distance to advance the continuous feed media to the top of form location from an end location of the image on the continuous feed media as the total length less bottom margin length, top margin length, and the length of the image.
17. The computer-readable storage device of claim 15 encoded with instructions that when executed cause the processor to compute the compensation factor to account for error in continuous feed media advance distance of the printer, a top margin length enforced by the printer, and a bottom margin length enforced by the printer.
18. The computer-readable storage device of claim 15 encoded with instructions that when executed cause the processor to compute the distance to advance such that the top of form location is always on an outer side of a fan fold form of the continuous feed media.
19. The computer-readable storage device of claim 15 encoded with instructions that when executed cause the processor to:
compute an average form length for the continuous feed media based on scales printed across form boundaries; and
compute the compensation factor based on the average form length.
20. The computer-readable storage device of claim 15 encoded with instructions that when executed cause the processor to:
print a scale across a form delimiter of the continuous media beyond the end of the image as part of printing the image; and
adjust the correction factor based on a reading of the scale.