1. A method of modulating activity of the GPR119 G protein-coupled receptor comprising administering to a mammalian patient in need thereof a therapeutically effective amount of at least one compound of Formula I or Formula IA and, optionally, an additional therapeutic agent wherein the compound of Formula I or Formula IA is selected from:
and enantiomers, diastereomers and pharmaceutically acceptable salts thereof having ring A and ring B, wherein:
ring A is optionally substituted with one or more R’s shown as R20 and R21;
G is CH or N;
Q is C or N;
X is CH or N, provided that Q and X are not both N;
Y is CH2, N(R3), C(O), O, OCR9R9, S, S(\u2550O) or S(O)2;
n1 is 0-2;
n2 is 0-2;
n3 is 1-2;
R1 is a 6-membered monocyclic aryl, a 5-membered monocyclic heteroaryl or a 6-membered monocyclic heteroaryl, each of which may be optionally substituted with one or more members selected from R1a, R1b, R1c, R1d and R1e;
R1a, R1b, R1c, R1d and R1e are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014SH, \u2014SR10, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)NR9S(O)2R9, \u2014S(O)2NR9C(\u2550O)OR9, \u2014S(O)2NR9C(\u2550O)NR9R9, \u2014C(\u2550O)NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(\u2550O)R10, \u2014OC(\u2550O)NR9R9, \u2014C(\u2550NR14)NR9R9, \u2014NHC(\u2550NR14NR14R14, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O)R8, wherein the alkyl alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl and heterocyclyl may each be optionally substituted with one or more R6’s; provided that at least one of R1a, R1b, R1c, R1d and R1e is heteroaryl;
R2 is cycloalkyl, aryl, heteroaryl, heterocyclyl, \u2014S(O)2R5, \u2014C(\u2550O)NR3R5, C(\u2550O)R5 or \u2014C(\u2550O)OR5, wherein the cycloalkyl, aryl, heteroaryl and heterocyclyl may each be optionally substituted with one or more R6’s;
R3 is hydrogen, alkyl, alkoxy, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl, wherein the heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each contain 1-4 heteroatoms selected from N, O and S;
R5 is alkyl, alkenyl, aryl, cycloalkyl, heteroaryl or heterocyclyl, each of which may be optionally substituted with one or more R6’s;
R6, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014SH, \u2014SR10, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)NR9S(O)2R9, \u2014S(O)2NR9C(\u2550O)OR9, \u2014S(O)2NR9C(\u2550O)NR9R9, \u2014C(\u2550O)NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(\u2550O)R10, \u2014C(\u2550NR14)NR9R9, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2550O, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl, alkenyl, alkynyl, aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a;
R8, at each occurrence, is independently selected from the group consisting of alkyl, aryl, cycloalkyl, heteroaryl and heterocyclyl, each of which may be optionally substituted with one or more R8a’s;
R8a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R14, \u2014S(O)2NR14C(\u2550O)OR14, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(\u2550O)NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2550O, \u2014NR14C(\u2550O)OR14 and \u2014NR14S(O2)R14;
R9, at each occurrence, is independently selected from hydrogen, alkyl, alkoxy, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl, wherein the alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a, and the heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl each contain 1-4 heteroatoms selected from N, O and S;
R9a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R10, \u2014S(O)2NR14C(\u2550O)OR10, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(\u2550O)NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(\u2550NR14)NR14R14, \u2014S(O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8, \u2014NR14S(O2)R8, \u2550O and arylalkyl;
R10, at each occurrence, is independently selected from alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl, wherein the cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-3 R10a, and the heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl each contain 1-4 heteroatoms selected from N, O and S;
R10a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R9, \u2014S(O)2NR14C(\u2550O)OR9, \u2014S(O)2NR14C(O)NR14R14, \u2014C(\u2550O)NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(O)R14, \u2014OC(\u2550O)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8, \u2014NR14S(O2)R8 and arylalkyl;
R14, at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl and aryl; and
R20 and R21 are each independently selected from the group consisting of hydrogen, alkyl, haloalkyl, cycloalkyl, halo, \u2014CN, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014C(\u2550O)NR9R9, \u2014C(\u2550O)R10 and \u2014OC(\u2550O)R10.
2. A method according to claim 1 wherein:
ring A is optionally substituted with one or more R’s shown as R20 and R21;
G is CH or N;
Q is C or N;
X is CH or N, provided that Q and X are not both N;
Y is CH2, N(R3), C(\u2550O), 0, OCR9R9, S, S(\u2550O) or S(O)2;
n1 is 0-2;
n2 is 0-2;
n3 is 1-2;
R1 is phenyl, pyridinyl, pyrazinyl or pyrimindinyl, each of which may be optionally substituted with one or more members selected from R1a, R1b, R1c, R1d and R1e;
R1a, R1b, R1c, R1d and R1e are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014SH, \u2014SR10, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(HO)NR9S(O)2R9, \u2014S(O)2NR9C(\u2550O)OR9, \u2014S(O)2NR9C(\u2550O)NR9R9, \u2014C(\u2550O)NR9S(O)2CF3\u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(\u2550O)R10, \u2014OC(\u2550O)NR9R9, \u2014C(\u2550NR14)NR9R9, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl and heterocyclyl may each be optionally substituted with one or more R’s; provided that at least one of R1a, R1b, R1c, R1d and R1e is heteroaryl;
R2 is cycloalkyl, aryl, heteroaryl, heterocyclyl, \u2014S(O)2R5, \u2014C(\u2550O)NR3R5, \u2014C(\u2550O)R5 or \u2014C(\u2550O)OR5, wherein the cycloalkyl, aryl, heteroaryl and heterocyclyl may each be optionally substituted with one or more R6’s;
R3 is hydrogen, alkyl alkoxy, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl;
R5 is alkyl, alkenyl, aryl, cycloalkyl, heteroaryl or heterocyclyl, each of which may be optionally substituted with one or more R6’s;
R6, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014SH, \u2014SR10, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)NR9S(O)2R9, \u2014S(O)2NR9C(\u2550O)OR9, \u2014S(O)2NR9C(\u2550O)NR9R9, \u2014C(\u2550O)NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(\u2550O)R10, \u2014C(\u2550NR14)NR9R9, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2550O, \u2014NR9C(O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl, alkenyl, alkynyl, aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a;
R8, at each occurrence, is independently selected from the group consisting of alkyl, aryl, cycloalkyl, heteroaryl and heterocyclyl, each of which may be optionally substituted with one or more R8a’s;
R8a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R14, \u2014S(O)2NR14C(\u2550O)OR14, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(\u2550O)NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2550O, \u2014NR14C(\u2550O)OR14 and \u2014NR14S(O2)R14;
R9, at each occurrence, is independently selected from hydrogen, alkyl, alkoxy, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl, wherein the alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a;
R9a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R10, \u2014S(O)2NR14C(\u2550O)OR10, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(\u2550O)NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8, \u2014NR14S(O2)R8, \u2550O and arylalkyl;
R10, at each occurrence, is independently selected from alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl, wherein the cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-3 R10a;
R10a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R9, \u2014S(O)2NR14C(\u2550O)OR9, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(\u2550O)NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8, \u2014NR14S(O2)R8 and arylalkyl;
R14, at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl and aryl; and
R20 and R21 are each independently selected from the group consisting of hydrogen, alkyl, haloalkyl, cycloalkyl, halo, \u2014CN, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014C(\u2550O)NR9R9, \u2014C(\u2550O)R10 and \u2014OC(\u2550O)R10.
3. A method according to claim 1 wherein:
ring A is optionally substituted with one or more R’s shown as R20 and R21;
G is CH or N;
Q is C or N;
X is CH or N, provided that Q and X are not both N;
Y is CH2, N(R3), C(\u2550O), 0, OCR9R9, S, S(\u2550O) or S(O)2;
n1 is 0-2;
n2 is 0-2;
n3 is 1-2;
R1 is
each of which may be optionally substituted with one or more members selected from the group consisting of R1a, R1b, R1c, R1d and R1e;
R1a, R1b, R1c, R1d and R1e are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014SH, \u2014SR10, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)NR9S(O)2R9, \u2014S(O)2NR9C(\u2550O)OR9, \u2014S(O)2NR9C(\u2550O)NR9R9, \u2014C(\u2550O)NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(\u2550O)R10, \u2014OC(\u2550O)NR9R9, \u2014C(\u2550NR14)NR9R9, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R10, \u2014S(O)R10, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R9, wherein the alkyl alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl and heterocyclyl may each be optionally substituted with one or more R6’s; provided that at least one of R1a, R1b, R1c, R1d and R1e is heteroaryl;
R2 is cycloalkyl, aryl, heteroaryl, heterocyclyl, \u2014S(O)2R5, \u2014C(\u2550O)NR3R5, \u2014C(\u2550O)R5 or C(\u2550O)OR5, wherein the cycloalkyl, aryl, heteroaryl and heterocyclyl may each be optionally substituted with one or more R6’s;
R3 is hydrogen, alkyl, alkoxy, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl, wherein the heteroaryl;
R5 is alkyl, alkenyl, aryl, cycloalkyl, heteroaryl or heterocyclyl, each of which may be optionally substituted with one or more R6’s;
R6, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014SH, \u2014SR10, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)NR9S(O)2R9, \u2014S(O)2NR9C(\u2550O)OR9, \u2014S(O)2NR9C(\u2550O)NR9R9, \u2014C(\u2550O)NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(O)R10, \u2014C(\u2550NR14)NR9R9, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2550O, \u2014NR9C(O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl, alkenyl, alkynyl, aryl cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a;
R8, at each occurrence, is independently selected from the group consisting of alkyl, aryl, cycloalkyl, heteroaryl and heterocyclyl, each of which may be optionally substituted with one or more R8a’s;
R8a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R14, \u2014S(O)2NR14C(\u2550O)OR14, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(\u2550O)NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(O)R14, \u2014OC(\u2550O)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2550O, \u2014NR14C(\u2550O)OR14 and \u2014NR14S(O2)R14;
R9, at each occurrence, is independently selected from hydrogen, alkyl, alkoxy, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl, wherein the alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclyalkyl may each be optionally substituted with 0-5 R9a;
R9a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014R14, \u2014OH, \u2014SR, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R10, \u2014S(O)2NR14C(\u2550O)OR14, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(\u2550O)NR14S(O)2CF3\u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8, \u2014NR14S(O2)R8, \u2550O and arylalkyl;
R10, at each occurrence, is independently selected from alkyl, alkenyl, alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl, wherein the cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-3 R10a;
R10a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R9, \u2014S(O)2NR14C(\u2550O)OR9, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(\u2550O)NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014C(\u2550NR14)NR14R14, NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8, \u2014NR14S(O2)R8 and arylalkyl;
R14, at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl and aryl;
R20 and R21 are each independently selected from the group consisting of hydrogen, alkyl, haloalkyl, cycloalkyl, halo, \u2014CN, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, OCF3, \u2014OR50, \u2014OH, \u2014C(\u2550O)NR9R9, \u2014C(\u2550O)R10 and \u2014OC(\u2550O)R10.
4. A method according to claim 1 wherein:
ring A is optionally substituted with one or more R’s shown as R20 and R21;
G is CH or N;
Q is C or N;
X is CH or N, provided that Q and X are not both N;
Y is CH2, N(R3), C(\u2550O), O, OCR9R9, S, S(\u2550O) or S(O)2;
n1 is 0-2;
n2 is 0-2;
n3 is 1-2;
R1 is a 6-membered monocyclic aryl, a 5-membered monocyclic heteroaryl or a 6-membered monocyclic heteroaryl, each of which may be optionally substituted with one or more members selected from R1a, R1b, R1c, R1d and R1e;
R1a, R1b, R1c, R1d and R1e are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014SH, \u2014SR10, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)NR9S(O)2R9, \u2014S(O)2NR9C(\u2550O)OR9, \u2014S(O)NR9C(\u2550O)NR9R9, \u2014C(\u2550O)NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(\u2550O)R10, \u2014OC(\u2550O)NR9R9, \u2014C(\u2550NR14)NR9R9, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2014NR9C(\u2550O)OR9 and \u2014NR9S(O2)R8, wherein the alkyl alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl and heterocyclyl may each be optionally substituted with one or more R6’s; provided that at least one of R1a, R1b, R1c, R1d and R1e is heteroaryl;
R2 is aryl, heteroaryl, heterocyclyl, \u2014C(\u2550O)NR3R5, \u2014C(\u2550O)R5 or \u2014C(\u2550O)OR5, wherein the aryl, heteroaryl and heterocyclyl may each be optionally substituted with one or more R6’s;
R3 is hydrogen, alkyl, alkoxy, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl;
R5 is alkyl, alkenyl, aryl, cycloalkyl, heteroaryl or heterocyclyl, each of which may be optionally substituted with one or more R6’s;
R6, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014SH, \u2014SR10, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)NR9S(O)2R9, \u2014S(O)2NR9C(\u2550O)OR9, \u2014S(O)2NR9C(\u2550O)NR9R9, \u2014C(\u2550O)NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC % (O)R10, \u2014C(\u2550NR14)NR9R9, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2550O, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R9, wherein the alkyl, alkenyl, alkynyl, aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a;
R8, at each occurrence, is independently selected from the group consisting of alkyl, aryl, cycloalkyl, heteroaryl and heterocyclyl, each of which may be optionally substituted with one or more R8a’s;
R8a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R14, \u2014S(O)2NR14C(\u2550O)OR14, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(\u2550O)NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014O, \u2014NR14C(\u2550O)OR14 and \u2014NR14S(O2)R14;
R9, at each occurrence, is independently selected from hydrogen, alkyl, alkoxy, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl, wherein the alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a;
R9a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH12, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R10, \u2014S(O)2NR14C(O)OR10, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(\u2550O)NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8, \u2014NR14S(O2)R8, \u2550O and arylalkyl;
R10, at each occurrence, is independently selected from alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl, wherein the cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-3 R10a;
R10a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R9, \u2014S(O)2NR14C(\u2550O)OR9, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(\u2550O)NR14S(O)2CF3, \u2014C\u2014O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8, \u2014NR14S(O2)R8 and arylalkyl;
R14, at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl and aryl; and
R20 and R21 are each independently selected from the group consisting of hydrogen, alkyl, haloalkyl, cycloalkyl, halo, \u2014CN, \u2014C(\u2550O)OH, \u2014C(\u2550O)R10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014C(\u2550O)NR9R9, \u2014C\u2550O)R10 and \u2014OC(O)R10.
5. A method according to claim 1 wherein:
ring A is optionally substituted with one or more R’s shown as R20 and R21;
G is CH or N;
Q is C or N;
X is CH or N, provided that Q and X are not both N;
Y is CH2, N(R3), C(\u2550O), O, OCR9R9, S, S(\u2550O) or S(O)2;
n1 is 0-2;
n2 is 0-2;
n3 is 1-2;
R1 is a 6-membered monocyclic aryl, a 5-membered monocyclic heteroaryl or a 6-membered monocyclic heteroaryl, each of which may be optionally substituted with one or more members selected from R1a, R1b, R1c, R1d and R1e;
R1a, R1b, R1c, R1d and R1e are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014SH, \u2014SR10, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)NR9S(O)2R9, \u2014S(O)2NR9C(\u2550O)OR9, \u2014S(O)2NR9C(\u2550O)NR9R9, \u2014C(\u2550O)NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(\u2550O)R10, \u2014OC(\u2550O)NR9R9, \u2014C(\u2550NR14)NR9R9, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl and heterocyclyl may each be optionally substituted with one or more R’s; provided that at least one of R1a, R1b, R1c, R1d and R1e is heteroaryl;
R2 is heteroaryl or \u2014C(\u2550O)OR5, wherein the heteroaryl may be optionally substituted with one or more R6’s;
R3 is hydrogen, alkyl, alkoxy, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl;
R5 is alkyl, alkenyl, aryl, cycloalkyl, heteroaryl or heterocyclyl, each of which may be optionally substituted with one or more R6’s;
R6, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014SH, \u2014SR10, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)NR9S(O)2R9, \u2014S(O)2NR9C(\u2550O)OR9, \u2014S(O)2NR9C(\u2550O)NR9R9, \u2014C(\u2550O)NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(\u2550O)R10, \u2014C(\u2550NR14)NR9R9, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2550O, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl, alkenyl, alkynyl, aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a;
R8, at each occurrence, is independently selected from the group consisting of alkyl, aryl, cycloalkyl, heteroaryl and heterocyclyl, each of which may be optionally substituted with one or more R8a’s;
R8a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R14, \u2014S(O)2NR14C(\u2550O)OR14, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(\u2550O)NR14S(O)CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2550O, \u2014NR14C(\u2550O)OR14 and \u2014NR14S(O2)R14;
R9, at each occurrence, is independently selected from hydrogen, alkyl, alkoxy, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl, wherein the alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a;
R9a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R10, \u2014S(O)2NR14C(\u2550O)OR10, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(\u2550O)NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(O)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8, \u2014NR14S(O2)R8, \u2550O and arylalkyl;
R10, at each occurrence, is independently selected from alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl, wherein the cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-3 R10a;
R10a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R9, \u2014S(O)2NR14C(\u2550O)OR9, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(\u2550O)NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550CO)OR8, \u2014NR14S(O2)R8 and arylalkyl;
R14, at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl and aryl; and
R20 and R21 are each independently selected from the group consisting of hydrogen, alkyl, haloalkyl, cycloalkyl, halo, \u2014CN, \u2014C(O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014C(\u2550O)NR9R9, \u2014C(\u2550O)R10 and \u2014OC(\u2550O)R10.
6. A method according to claim 1 wherein:
ring A is optionally substituted with one or more R’s shown as R20 and R21;
G is CH or N;
Q is C or N;
X is CH or N, provided that Q and X are not both N;
Y is CH2, N(R3), C(\u2550O), 0, OCR9R9, S, S(\u2550O) or S(O)2;
n1 is 0-2;
n2 is 0-2;
n3 is 1-2;
R1 is a 6-membered monocyclic aryl, a 5-membered monocyclic heteroaryl or a 6-membered monocyclic heteroaryl, each of which may be optionally substituted with one or more members selected from R1a, R1b, R1c, R1d and R1e;
R1a, R1b, R1c, R1d and R1e are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014SH, \u2014SR10, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)NR9S(O)2R9, \u2014S(O)2NR9C(\u2550O)OR9, \u2014S(O)2NR9C(\u2550O)NR9R9, \u2014C(\u2550O)NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(\u2550O)R10, \u2014OC(\u2550O)NR9R9, \u2014C(NR14)NR9R9, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl and heterocyclyl may each be optionally substituted with one or more R6’s; provided that at least one of R1a, R1b, R1c, R1d and R1e is heteroaryl;
R2 is heteroaryl which may be optionally substituted with one or more R6’s;
R3 is hydrogen, alkyl, alkoxy, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl;
R6, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014SH, \u2014SR10, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)NR9S(O)2R9, \u2014S(O)2NR9C(\u2550O)OR9, \u2014S(O)2NR9C(\u2550O)NR9R9, \u2014C(\u2550O)NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(\u2550O)R10, \u2014C(NR14)NR9R9, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2550O, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl, alkenyl, alkynyl, aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a;
R8, at each occurrence, is independently selected from the group consisting of alkyl, aryl, cycloalkyl, heteroaryl and heterocyclyl, each of which may be optionally substituted with one or more R8a’s;
R8a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(O)NR14S(O)2R14, \u2014S(O)2NR14C(\u2550O)OR14, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(O)NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(O)R14, \u2014OC(\u2550O)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2550O, \u2014NR14C(\u2550O)OR14 and \u2014NR14S(O2)R14;
R9, at each occurrence, is independently selected from hydrogen, alkyl, alkoxy, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl, wherein the alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a;
R9a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R10, \u2014S(O)2NR14C(\u2550O)OR10, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(\u2550O)NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8, \u2014NR14S(O2)R8, \u2550O and arylalkyl;
R10, at each occurrence, is independently selected from alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl, wherein the cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-3 R10a;
R10a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R9, \u2014S(O)2NR14C(\u2550O)OR9, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(\u2550O)NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8, \u2014NR14S(O2)R8 and arylalkyl;
R14, at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl and aryl; and
R20 and R21 are each independently selected from the group consisting of hydrogen, alkyl, haloalkyl, cycloalkyl, halo, \u2014CN, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014C(\u2550O)NR9R9, \u2014C(\u2550O)R10 and \u2014OC(\u2550O)R10.
7. A method according to claim 1 wherein:
ring A is optionally substituted with one or more R’s shown as R20 and R21;
G is CH or N;
Q is C or N;
X is CH;
Y is CH2, N(R3), C(\u2550O), 0, OCR9R9, S, S(\u2550O) or S(O)2;
n1 is 0-2;
n2 is 0-2;
n3 is 1-2;
R1 is a 6-membered monocyclic aryl, a 5-membered monocyclic heteroaryl or a 6-membered monocyclic heteroaryl, each of which may be optionally substituted with one or more members selected from R1a, R1b, R1c, R1d and R1e;
R1a, R1b, R1c, R1d and R1e are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014SH, \u2014SR10, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)NR9S(O)2R9, \u2014S(O)2NR9C(\u2550O)OR9, \u2014S(O)2NR9C(\u2550O)NR9R9, \u2014C(O)NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(\u2550O)R10, \u2014OC(\u2550O)NR9R9, \u2014C(\u2550NR14)NR9R9, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl and heterocyclyl may each be optionally substituted with one or more R’s; provided that at least one of R1a, R1b, R1c, R1d and R1e is heteroaryl;
R2 is cycloalkyl, aryl, heteroaryl, heterocyclyl, \u2014S(O)2R5, \u2014C(\u2550O)NR3R5, \u2014C(\u2550O)R5 or \u2014C(\u2550O)OR5, wherein the cycloalkyl, aryl, heteroaryl and heterocyclyl may each be optionally substituted with one or more R6’s;
R3 is hydrogen, alkyl, alkoxy, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl;
R5 is alkyl, alkenyl, aryl, cycloalkyl, heteroaryl or heterocyclyl, each of which may be optionally substituted with one or more R6’s,
R6, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014SH, \u2014SR10, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)NR9S(O)2R9, \u2014S(O)2NR9C(\u2550O)OR9, \u2014S(O)2NR9C(O)NR9R9, \u2014C(\u2550O)NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(\u2550O)R10, \u2014C(\u2550NR14)NR9R9, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2550O, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl, alkenyl, alkynyl, aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a;
R8, at each occurrence, is independently selected from the group consisting of alkyl, aryl, cycloalkyl, heteroaryl and heterocyclyl, each of which may be optionally substituted with one or more R8a’s;
R8a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R14, \u2014S(O)2NR14C(\u2550O)OR14, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(\u2550O)NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2550O, \u2014NR14C(\u2550O)OR14 and \u2014NR14S(O2)R14;
R9, at each occurrence, is independently selected from hydrogen, alkyl, alkoxy, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl, wherein the alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a;
R9a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014O, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R10, \u2014S(O)2NR14C(\u2550O)OR10, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(O)NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(\u2550NR14NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR9, \u2014NR14S(O2)R9, \u2550O and arylalkyl;
R10, at each occurrence, is independently selected from alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl, wherein the cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-3 R10a;
R10a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R9, \u2014S(O)2NR14C(\u2550O)OR9, \u2014S(O)2NR14C\u2014O)NR14R14, \u2014C(\u2550O)NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR9, \u2014NR14S(O2)R8 and arylalkyl;
R14, at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl and aryl;
R20 is hydrogen; and
R21 is selected from the group consisting of hydrogen, alkyl, haloalkyl, cycloalkyl, halo, \u2014CN, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014C(\u2550O)NR9R9, \u2014C(\u2550O)R10 and \u2014OC(\u2550O)R10.
8. A method according to claim 1, wherein the compound is selected from compounds of Formula IA in which:
ring A is optionally substituted with one or more R’s shown as R20 and R21;
G is CH or N;
Q is C;
X is CH;
Y is CH2, N(R3), C(\u2550O), O, OCR9R9, S, S(\u2550O) or S(O)2;
n1 is 0-2;
n2 is 0-2;
R1 is a 6-membered monocyclic aryl, a 5-membered monocyclic heteroaryl or a 6-membered monocyclic heteroaryl, each of which may be optionally substituted with one or more members selected from R1a, R1b, R1c, R1d and R1e;
R1a, R1b, R1c, R1d and R1e are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014SH, \u2014SR10, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)NR9S(O)2R9, \u2014S(O)2NR9C(\u2550O)OR9, \u2014S(O)2NR9C(\u2550O)NR9R9, \u2014C(\u2550O)NR9S(O)2CF3, \u2014C(O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(\u2550O)R10, \u2014OC(\u2550O)NR9R9, \u2014C(\u2550NR14)NR9R9, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl and heterocyclyl may each be optionally substituted with one or more R6’s; provided that at least one of R1a, R1b, R1c, R1d and R1e is heteroaryl;
R2 is cycloalkyl, aryl, heteroaryl, heterocyclyl, \u2014S(O)2R5, \u2014C(\u2550O)NR3R5, \u2014C(\u2550O)R5 or \u2014C(O)OR5, wherein the cycloalkyl, aryl, heteroaryl and heterocyclyl may each be optionally substituted with one or more R6’s;
R3 is hydrogen, alkyl, alkoxy, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl;
R5 is alkyl, alkenyl, aryl, cycloalkyl, heteroaryl or heterocyclyl, each of which may be optionally substituted with one or more R6’s;
R6, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014SH, \u2014SR10, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)NR9S(O)2R9, \u2014S(O)2NR9C(\u2550O)OR9, \u2014S(O)2NR9C(\u2550O)NR9R9, \u2014C(\u2550O)NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(\u2550O)R10, \u2014C(NR14)NR9R9, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2550O, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl, alkenyl, alkynyl, aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a;
R8, at each occurrence, is independently selected from the group consisting of alkyl, aryl, cycloalkyl, heteroaryl and heterocyclyl, each of which may be optionally substituted with one or more R8a’s;
R8a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R14, \u2014S(O)2NR14C(\u2550O)OR14, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(\u2550O)NR14S(O)2CF3\u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014C(NR14)NR14R14, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2550O, \u2014NR14C(\u2550O)OR14 and \u2014NR14S(O2)R14;
R9, at each occurrence, is independently selected from hydrogen, alkyl, alkoxy, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl, wherein the alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a;
R9a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R10, \u2014S(O)2NR14C(\u2550O)OR10, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(\u2550O)NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8, \u2014NR14S(O2)R8, \u2550O and arylalkyl;
R10, at each occurrence, is independently selected from alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl, wherein the cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-3 R10a;
R10a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R9, \u2014S(O)2NR14C(\u2550O)OR9, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(\u2550O)NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C((\u2550O)R14, \u2014OC(\u2550O)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8, \u2014NR14S(O2)R9 and arylalkyl;
R14, at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl and aryl;
R20 is hydrogen; and
R21 is selected from the group consisting of hydrogen, alkyl, haloalkyl, cycloalkyl, halo, \u2014CN, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014C(\u2550O)NR9R9, \u2014C(\u2550O)R10 and \u2014OC(O)R10.
9. A method according to claim 1, wherein the compound is selected from compounds of Formula I in which:
ring A is optionally substituted with one or more K’s shown as R20 and R21;
G is CH or N;
Q is C;
X is CH;
Y is CH2, N(R3), C(O), O, OCR9R9, S, S(\u2550O) or S(O)2;
n1 is 0-2;
n2 is 0-2;
n3 is 2;
R1 is a 6-membered monocyclic aryl, a 5-membered monocyclic heteroaryl or a 6-membered monocyclic heteroaryl, each of which may be optionally substituted with one or more members selected from R1a, R1b, R1c, R1d and R1e;
R1a, R1b, R1c, R1d and R1e are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, halo, \u2014NH2, \u2014CN, \u2014NO2\u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, OH, \u2014SH, \u2014SR10, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)NR9S(O)2R9, \u2014S(O)2NR9C(\u2550O)OR9, \u2014S(O)2NR9C(\u2550O)NR9R9, \u2014C(\u2550O)NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(\u2550O)R10, \u2014OC(\u2550O)NR9R9, \u2014C(\u2550NR14)NR9R9, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl and heterocyclyl may each be optionally substituted with one or more R6’s; provided that at least one of R1a, R1b, R1c, R1d and R1e is heteroaryl;
R2 is cycloalkyl, aryl, heteroaryl, heterocyclyl, \u2014S(O)2R5, \u2014C(\u2550O)NR3R5, \u2014C(\u2550O)R5 or \u2014C(\u2550O)OR5, wherein the cycloalkyl, aryl, heteroaryl and heterocyclyl may each be optionally substituted with one or more R6’s;
R3 is hydrogen, alkyl, alkoxy, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl;
R5 is alkyl, alkenyl, aryl, cycloalkyl, heteroaryl or heterocyclyl, each of which may be optionally substituted with one or more R6’s;
R6, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2\u2014C(O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014SH, \u2014SR10, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)NR9S(O)2R9, \u2014S(O)2NR9C(\u2550O)OR9, \u2014S(O)2NR9C(\u2550O)NR9R9, \u2014C(\u2550O)NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(\u2550O)R10, \u2014C(\u2550NR14)NR9R9, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2550O, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl, alkenyl, alkynyl, aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a;
R8, at each occurrence, is independently selected from the group consisting of alkyl, aryl, cycloalkyl, heteroaryl and heterocyclyl, each of which may be optionally substituted with one or more R8a’s;
R8a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R14, \u2014S(O)2NR14C(\u2550O)OR14, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(\u2550O)NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O\u2014)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2550O, \u2014NR14C(\u2550O)OR14 and \u2014NR14S(O2)R14;
R9, at each occurrence, is independently selected from hydrogen, alkyl, alkoxy, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl, wherein the alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a;
R9a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R10, \u2014S(O)2NR14C(\u2550O)OR10, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(\u2550O)NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8, \u2014NR14S(O2)R8, \u2550O and arylalkyl;
R10, at each occurrence, is independently selected from alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl, wherein the cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-3 R10a;
R10a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014NH2, \u2014CN, \u2014NO2, \u2014C(\u2550O)OH, \u2014C(O)OR14, \u2014OCF3, \u2014OR14, \u2014O, \u2014SH, \u2014SR14, \u2014S(O)3H, \u2014P(O)3H2, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)NR14S(O)2R9, \u2014S(O)2NR14C(\u2550O)OR9, \u2014S(O)2NR14C(\u2550O)NR14R14, \u2014C(\u2550O)NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014C(\u2550NR14)NR14R14, \u2014NHC(\u2550NR14)NR14R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8, \u2014NR14S(O2)R8 and arylalkyl;
R14, at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl and aryl;
R20 is hydrogen; and
R21 is selected from the group consisting of hydrogen, alkyl, haloalkyl, cycloalkyl, halo, \u2014CN, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014C(\u2550O)NR9R9, \u2014C(\u2550O)R10 and \u2014OC(\u2550O)R10.
10. A method according to claim 1, wherein the compound is selected from compounds of Formula IA in which:
ring A is optionally substituted with one or more R’s shown as R20 and R21;
G is CH or N;
Q is C;
X is CH;
Y is O, OCR9R9, or S;
n1 is 1;
n2 is 1;
R1 is phenyl or a 6-membered monocyclic heteroaryl, each of which may be optionally substituted with one or more members selected from R1a, R1b, R1c, R1d and R1e;
R1a, R1b, R1d and R1e are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, halo, \u2014CN, \u2014OCF3, \u2014OR10, \u2014OH, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(\u2550O)R10, \u2014OC(\u2550O)NR9R9, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl, alkenyl, alkynyl and cycloalkyl may each be optionally substituted with one or more R6’s;
R1c is a 5-6 membered monocyclic heteroaryl which may be optionally substituted with one or more R6’s;
R2 is heteroaryl or \u2014C(\u2550O)OR5, wherein the heteroaryl may be optionally substituted with one or more R6’s;
R5 is alkyl, alkenyl, aryl, cycloalkyl, heteroaryl or heterocyclyl, each of which may be optionally substituted with one or more R6’s;
R6, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014CN, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014SH, \u2014SR10, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(\u2550O)R10, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2550O, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl, alkenyl, alkynyl, aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a;
R8, at each occurrence, is independently selected from the group consisting of alkyl, aryl, cycloalkyl, heteroaryl and heterocyclyl, each of which may be optionally substituted with one or more R8a’s;
R8a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl cycloalkyl, halo, \u2014NH2, \u2014CN, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2550O, \u2014NR14C(\u2550O)OR14 and \u2014NR14S(O2)R14;
R9, at each occurrence, is independently selected from hydrogen, alkyl, alkoxy, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl, wherein the alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a;
R9a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, halo, \u2014NH2, \u2014CN, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8, \u2014NR14S(O2)R8 and \u2550O;
R10, at each occurrence, is independently selected from alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl, wherein the cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-3 R10a;
R10a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, halo, \u2014NH2, \u2014CN, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8 and \u2014NR14S(O2)R8;
R14, at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl and aryl;
R20 is hydrogen; and
R21 is selected from the group consisting of hydrogen, alkyl, haloalkyl, cycloalkyl, halo, \u2014CN, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014C(\u2550O)NR9R9, \u2014C(\u2550O)R10 and \u2014OC(\u2550O)R10.
11. A method according to claim 1, wherein the compound is selected from compounds of Formula I in which:
ring A is optionally substituted with one or more R’s shown as R20 and R21;
G is CH or N;
Q is C;
X is CH;
Y is O, OCR9R9, or S;
n1 is 1;
n2 is 1;
n3 is 2;
R1 is phenyl or a 6-membered monocyclic heteroaryl, each of which may be optionally substituted with one or more members selected from R1a, R1b, R1c, R1d and R1e;
R1a, R1b, R1d and R1e are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, halo, \u2014CN, \u2014OCF3, \u2014OR10, \u2014OH, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(O)R10, \u2014OC(\u2550O)R10, \u2014OC(\u2550O)NR9R9, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl, alkenyl, alkynyl and cycloalkyl may each be optionally substituted with one or more R6’s;
R1c is a 5-6 membered monocyclic heteroaryl which may be optionally substituted with one or more R6’s;
R2 is heteroaryl or \u2014C(\u2550O)OR5, wherein the heteroaryl may be optionally substituted with one or more R6’s;
R5 is alkyl, alkenyl, aryl, cycloalkyl, heteroaryl or heterocyclyl, each of which may be optionally substituted with one or more R6’s;
R6, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014CN, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014SH, \u2014SR10, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(HO)R10, \u2014OC(\u2550O)R10, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2550O, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl, alkenyl, alkynyl, aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a;
R8, at each occurrence, is independently selected from the group consisting of alkyl, aryl, cycloalkyl, heteroaryl and heterocyclyl, each of which may be optionally substituted with one or more R8a’s;
R8a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, halo, \u2014NH2, \u2014CN, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2550O, \u2014NR14C(\u2550O)OR14 and \u2014NR14S(O2)R14;
R9, at each occurrence, is independently selected from hydrogen, alkyl, alkoxy, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl, wherein the alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a;
R9a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, halo, \u2014NH2, \u2014CN, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8, \u2014NR14S(O2)R8 and \u2550O;
R10, at each occurrence, is independently selected from alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl, wherein the cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-3 R10a;
R10a, at each occurrence, is in dependently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, halo, \u2014NH2, \u2014CN, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8 and \u2014NR14S(O2)R8;
R14, at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl and aryl;
R20 is hydrogen; and
R21 is selected from the group consisting of hydrogen, alkyl haloalkyl, cycloalkyl, halo, \u2014CN, \u2014C(O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014C(\u2550O)NR9R9, \u2014C(\u2550O)R10 and \u2014OC(O)R10.
12. A method according to claim 1, wherein the compound is selected from compounds of Formula IA in which:
ring A is optionally substituted with one or more R’s shown as R20 and R21;
G is N;
Q is C;
X is CH;
Y is O;
n1 is 1;
n2 is 1;
R1 is phenyl or a 6-membered monocyclic heteroaryl, each of which may be optionally substituted with one or more members selected from R1a, R1b, R1c, R1d and R1e;
Ra1, R1b, R1d and R1e are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, halo, \u2014CN, \u2014OCF3, \u2014OR10, \u2014OH, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(\u2550O)R10, \u2014OC(\u2550O)NR9R9, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl, alkenyl, alkynyl and cycloalkyl may each be optionally substituted with one or more R6’s;
R1c is a 5-6 membered monocyclic heteroaryl which may be optionally substituted with one or more R6’s;
R2 is heteroaryl or \u2014C(\u2550O)OR5, wherein the heteroaryl may be optionally substituted with one or more R6’s;
R5 is alkyl, alkenyl, aryl, cycloalkyl, heteroaryl or heterocyclyl, each of which may be optionally substituted with one or more R6’s;
R6, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014CN, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014SH, \u2014SR10, \u2014C(O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C\u2550O)R10, \u2014OC(\u2550O)R10, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2550O, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl, alkenyl, alkynyl, aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a;
R8, at each occurrence, is independently selected from the group consisting of alkyl and cycloalkyl, each of which may be optionally substituted with one or more R8a’s;
R8a, at each occurrence, is independently selected from allyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, halo, \u2014NH2, \u2014CN, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2550O, \u2014NR14C(\u2550O)OR14 and \u2014NR14S(O2)R14;
R9, at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl and aryl, wherein the alkyl, cycloalkyl and aryl may each be optionally substituted with 0-5 R9a;
R9a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, halo, \u2014NH2, \u2014CN, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8, \u2014NR14S(O2)R8 and \u2550O;
R10, at each occurrence, is independently selected from alkyl, cycloalkyl, and aryl, which may each be optionally substituted with 0-3 R10a;
R10a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, halo, \u2014NH2\u2014CN, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8 and \u2014NR14S(O2)R8;
R14, at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl and aryl;
R20 is hydrogen; and
R21 is selected from the group consisting of hydrogen, alkyl, haloalkyl, cycloalkyl, halo, \u2014CN, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014O(\u2550O)NR9R9, \u2014C(O)R10 and \u2014OC(\u2550O)R10.
13. A method according to claim 1, wherein the compound is selected from compounds of Formula I in which;
ring A is optionally substituted with one or more R’s shown as R20 and R21;
G is N;
Q is C;
X is CH;
Y is O;
n1 is 1;
n2 is 1;
n3 is 2;
R1 is phenyl or a 6-membered monocyclic heteroaryl, each of which may be optionally substituted with one or more members selected from R1a, R1b, R1c, R1d and R1e;
R1a, R1b, R1d and R1e are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, halo, \u2014CN, \u2014OCF3, \u2014OR10, \u2014OH, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(O)R10, \u2014OC(\u2550O)NR9R9, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl, alkenyl, alkynyl and cycloalkyl may each be optionally substituted with one or more R6’s;
R1c is a 5-6 membered monocyclic heteroaryl which may be optionally substituted with one or more R6’s;
R2 is heteroaryl or \u2014O(\u2550O)OR5, wherein the heteroaryl may be optionally substituted with one or more R6’s;
R5 is alkyl, alkenyl, aryl, cycloalkyl, heteroaryl or heterocyclyl, each of which may be optionally substituted with one or more R6’s;
R6, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014CN, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014SH, \u2014SR10, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(\u2550O)R10, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2550O, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl, alkenyl, alkynyl, aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a;
R8, at each occurrence, is independently selected from the group consisting of alkyl and cycloalkyl, each of which may be optionally substituted with one or more R8a’s;
R8a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, halo, \u2014NH2, \u2014ON, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(O)R14, \u2014OC(\u2550O)R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2550O, \u2014NR14C(O)OR14 and \u2014NR14S(O2)R14;
R9, at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl and aryl, which may each be optionally substituted with 0-5 R9a;
R9a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, halo, \u2014NH2, \u2014CN, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8, \u2014NR14S(O2)R8 and \u2550O;
R10, at each occurrence, is independently selected from alkyl, cycloalkyl and aryl, which may each be optionally substituted with 0-3 R10a;
R10a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, halo, \u2014NH2, \u2014CN, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8 and \u2014NR14S(O2)R8;
R14, at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl and aryl;
R20 is hydrogen; and
R21 is selected from the group consisting of hydrogen, alkyl, haloalkyl, cycloalkyl, halo, \u2014CN, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014C(\u2550O)NR9R9, \u2014C(\u2550O)R10 and \u2014OC(\u2550O)R10.
14. A method according to claim 1, wherein the compound is selected from compounds of Formula IA in which:
ring A is optionally substituted with one or more R’s shown as R20 and R21; G is N;
Q is C;
X is CH;
Y is O;
n1 is 1;
n2 is 1;
R1 is
R1a, R1b, R1d and R1c are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, halo, \u2014CN, \u2014OCF3, \u2014OR10, \u2014OH, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(O)H, \u2014NR9C(\u2550O)R10, \u2014OC(\u2550O)R10, \u2014OC(\u2550O)NR9R9, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl, alkenyl, alkynyl and cycloalkyl may each be optionally substituted with one or more R6’s,
R1c is a 5-6 membered monocyclic heteroaryl which may be optionally substituted with one or more R6’S;
R2 is pyridinyl pyrimidinyl or \u2014C(\u2550O)OR5, wherein the pyridinyl and pyrimidinyl may each be optionally substituted with one or more R6’s;
R5 is alkyl, aryl or cycloalkyl, each of which may be optionally substituted with one or more R6’s;
R6, at each occurrence, is independently selected from all, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014CN, \u2014C(\u2550O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014SH, \u2014SR10, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(\u2550O)R10, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2550O, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl, alkenyl, alkynyl, aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a;
R8, at each occurrence, is independently selected from the group consisting of alkyl and cycloalkyl, each of which may be optionally substituted with one or more R8a’s;
R8a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, halo, \u2014NH2, \u2014CN, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2550O, \u2014NR14C(\u2550O)OR14 and \u2014NR14S(O2)R14;
R9, at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl and aryl, wherein the alkyl, cycloalkyl and aryl may each be optionally substituted with 0-5 R9a;
R9a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, halo, \u2014NH2, \u2014CN, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8, \u2014NR14S(O2)R8 and \u2550O;
R10, at each occurrence, is independently selected from alkyl, cycloalkyl and aryl, which may each be optionally substituted with 0-3 R10a;
R10a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, halo, \u2014NH2, \u2014CN, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014S(O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8 and \u2014NR14S(O2)R8;
R14, at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl and aryl;
R20 is hydrogen; and
R21 is selected from the group consisting of hydrogen, alkyl, haloalkyl, halo and \u2014CN.
15. A method according to claim 1, wherein the compound is selected from compounds of Formula I in which:
ring A is optionally substituted with one or more R’s shown as R20 and R21;
G is N;
Q is C;
X is CH;
Y is O;
n1 is 1;
n2 is 1;
n3 is 2;
R1 is
R1a, R1b, R1d and R1e are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, halo, \u2014CN, \u2014OCF3, \u2014OR10, \u2014OH, \u2014C(O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(\u2550O)R10, \u2014OC(\u2550O)NR9R9, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl, alkenyl, alkynyl and cycloalkyl may each be optionally substituted with one or more R6’s;
R1c is a 5-6 membered monocyclic heteroaryl which may be optionally substituted with one or more R6’s;
R2 is pyridinyl, pyrimidinyl or \u2014C(\u2550O)OR5, wherein the pyridinyl and pyrimidinyl may each be optionally substituted with one or more R6’s;
R5 is alkyl, aryl or cycloalkyl, each of which may be optionally substituted with one or more R6’s;
R6, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, \u2014CN, \u2014C(O)OR10, \u2014OCF3, \u2014OR10, \u2014OH, \u2014SH, \u2014SR10, \u2014C(\u2550O)NR9R9, \u2014NR9R9, \u2014S(O)2NR9R9, \u2014NR9S(O)2CF3, \u2014C(\u2550O)R10, \u2014NR9C(\u2550O)H, \u2014NR9C(\u2550O)R10, \u2014OC(\u2550O)R10, \u2014S(\u2550O)R10, \u2014S(O)2R10, \u2550O, \u2014NR9C(\u2550O)OR8 and \u2014NR9S(O2)R8, wherein the alkyl, alkenyl, alkynyl, aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R9a;
R8, at each occurrence, is independently selected from the group consisting of alkyl and cycloalkyl, each of which may be optionally substituted with one or more R8a’s;
R8a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, halo, \u2014NH2, \u2014CN, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2550O, \u2014NR14C(\u2550O)OR14 and \u2014NR14S(O2)R14;
R9, at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl and aryl, wherein the alkyl, cycloalkyl and aryl may each be optionally substituted with 0-5 R9a;
R9a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, halo, \u2014NH2, \u2014CN, \u2014C(\u2550O)OH, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(\u2550O)R14, \u2014OC(\u2550O)R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8, \u2014NR14S(O2)R8 and \u2550O;
R10, at each occurrence, is independently selected from alkyl, cycloalkyl and aryl, which may each be optionally substituted with 0-3 R10a;
R10a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, halo, \u2014NH2, \u2014CN, \u2014C(\u2550O)OR14, \u2014OCF3, \u2014OR14, \u2014OH, \u2014C(\u2550O)NR14R14, \u2014NR14R14, \u2014S(O)2NR14R14, \u2014NR14S(O)2CF3, \u2014C(\u2550O)R14, \u2014NR14C(\u2550O)H, \u2014NR14C(HQ)R14, \u2014OC(\u2550O)R14, \u2014S(\u2550O)R14, \u2014S(O)2R14, \u2014NR14C(\u2550O)OR8 and \u2014NR14S(O2)R8;
R14, at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl and aryl;
R20 is hydrogen; and
R21 is selected from the group consisting of hydrogen, alkyl, haloalkyl, halo and \u2014CN.
16. The method of claim 1 comprising the use of an additional therapeutic agent.
17. The method of claim 16 wherein the additional therapeutic agent is a dipeptidyl peptidase-IV (DPP4) inhibitor.
18. A compound of Formula IA:
and enantiomers, diastereomers and pharmaceutically acceptable salts thereof, wherein:
ring A is optionally substituted with one or more R’s shown as R20 and R21;
G is N;
Q is C;
X is CH;
Y is O;
n1 is 1;
n2 is 1;
R1 is
R1a, R1b, R1d and R1e are each independently selected from the group consisting of hydrogen, halo, CN and C1-3 alkyl;
R1c is imidazolyl, oxazolyl or triazolyl;
R2 is pyrimidinyl or \u2014C(\u2550O)OR5, wherein the pyrimidinyl may be optionally substituted with C1-3 alkyl;
R5 is C1-3 alkyl;
R20 is hydrogen; and
R21 is hydrogen, halo or CN.
19. A compound according to claim 18, wherein the compound is
20. A method of modulating the activity of the GPR119 G protein-coupled receptor comprising administering to a mammalian patient in need thereof a therapeutically effective amount of at least one compound of claim 19 and, optionally, an additional therapeutic agent.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method for avoiding read-after-write (RAW) hazards while speculatively executing instructions on a processor, comprising:
issuing instructions for execution during a normal execution mode;
upon encountering a stall condition during execution of an instruction, generating a checkpoint, and executing the instruction and subsequent instructions in a speculative-execution mode, wherein the stall condition is a data-dependent stall condition, and wherein the speculative-execution mode is an execute-ahead mode, wherein instructions that cannot be executed because of an unresolved data dependency are deferred, and wherein other non-deferred instructions are executed in program order;
maintaining dependency information for each register indicating whether or not a value in the register depends on an unresolved data-dependency; and
using the dependency information to avoid RAW hazards during the speculative-execution mode;
wherein if the data-dependent stall condition is resolved during execute-ahead mode, the method further comprises executing deferred instructions in a deferred execution mode by:
issuing deferred instructions for execution in program order;
deferring execution of deferred instructions that still cannot be executed because of unresolved data dependencies;
executing other deferred instructions that are able to be executed in program order: and
if all deferred instructions are executed, returning to the normal execution mode to resume normal program execution from the point where the execute-ahead mode left off.
2. The method of claim 1, wherein maintaining dependency information for each register involves:
maintaining a \u201cnot-there\u201d bit for each register, indicating whether a value the register can be resolved;
setting the not-there bit of a destination register for a memory reference if the memory reference has not returned a value to the destination register; and
setting the not-there bit of a destination register of an instruction if the not-there bit of any corresponding source register for the instruction is set.
3. The method of claim 2, wherein maintaining dependency information for each register involves clearing the not-there bit of a destination register for an instruction that successfully executes without encountering an unresolved data dependency.
4. The method of claim 1,
wherein the speculative-execution mode is a scout mode, wherein instructions are speculatively executed to prefetch future memory operations, but wherein results are not committed to the architectural state of the processor;
wherein when the stall condition that caused the processor to enter the scout mode is finally resolved, the method further comprises using the checkpoint to resume execution in the normal execution mode from the instruction that originally encountered the stall condition.
5. The method of claim 1, wherein if some deferred instruction are deferred again, the method further comprises returning to execute-ahead mode at the point where execute-ahead mode left off.
6. The method of claim 1, wherein using the dependency information to avoid RAW hazards during the speculative-execution mode involves deferring instructions that are subject to unresolved data dependencies.
7. The method of claim 1, wherein using the dependency information to avoid RAW hazards during the speculative-execution mode involves ignoring the results of instructions that are subject to unresolved data dependencies.
8. The method of claim 1, wherein generating the checkpoint involves saving a precise architectural state of the processor.
9. The method of claim 1, wherein an unresolved data dependency can include:
a use of an operand that has not returned from a preceding load miss;
a use of an operand that has not returned from a preceding translation lookaside buffer (TLB) miss;
a use of an operand that has not returned from a preceding full or partial read-after-write (RAW) from store buffer operation; and
a use of an operand that depends on another operand that is subject to an unresolved data dependency.
10. An apparatus that avoids read-after-write (RAW) hazards while speculatively executing instructions on a processor, comprising:
an issuing mechanism configured to issue instructions for execution during a normal execution mode; and
an execution mechanism;
wherein upon encountering a stall condition during execution of an instruction, the execution mechanism is configured to generate a checkpoint, and to execute the instruction and subsequent instructions in a speculative-execution mode, wherein the stall condition is a data-dependent stall condition, and wherein the speculative-execution mode is an execute-ahead mode, wherein instructions that cannot be executed because of an unresolved data dependency are deferred, and wherein other non-deferred instructions are executed in program order;
wherein the execution mechanism is configured to maintain dependency information for each register indicating whether or not a value in the register depends on an unresolved data-dependency; and
wherein the execution mechanism is configured to use the dependency information to avoid RAW hazards during the speculative-execution mode;
wherein if the data-dependent stall condition is resolved during execute-ahead mode, the execution mechanism is configured to execute deferred instructions in a deferred execution mode by:
issuing deferred instructions for execution in program order:
deferring execution of deferred instructions that still cannot be executed because of unresolved data dependencies;
executing other deferred instructions that are able to be executed in program order; and
if all deferred instructions are executed, to return to the normal execution mode to resume normal program execution from the point where the execute ahead mode left off.
11. The apparatus of claim 10, wherein maintaining dependency information for each register involves:
maintaining a \u201cnot-there\u201d bit for each register, indicating whether a value in the register can be resolved;
setting the not-there bit of a destination register for a memory reference if the memory reference has not returned a value to the destination register; and
setting the not-there bit of a destination register of an instruction if the not-there bit of any corresponding source register for the instruction is set.
12. The apparatus of claim 11, wherein maintaining dependency information for each register involves clearing the not-there bit of a destination register for an instruction that successfully executes without encountering an unresolved data dependency.
13. The apparatus of claim 10,
wherein the speculative-execution mode is a scout mode, wherein instructions are speculatively executed to prefetch future memory operations, but wherein results are not committed to the architectural state of the processor;
wherein when the stall condition that caused the processor to enter the scout mode is finally resolved, the execution mechanism is configured to use the checkpoint to resume execution in the normal execution mode from the instruction that originally encountered the stall condition.
14. The apparatus of claim 10, wherein if some deferred instruction are deferred again, the execution mechanism is configured to return to execute-ahead mode at the point where execute-ahead mode left off.
15. The apparatus of claim 10, wherein using the dependency information to avoid RAW hazards during the speculative-execution mode involves deferring instructions that are subject to unresolved data dependencies.
16. The apparatus of claim 10, wherein using the dependency information to avoid RAW hazards during the speculative-execution mode involves ignoring the results of instructions that are subject to unresolved data dependencies.
17. The apparatus of claim 10, wherein generating the checkpoint involves saving a precise architectural state of the processor.
18. The apparatus of claim 10, wherein an unresolved data dependency can include:
a use of an operand that has not returned from a preceding load miss;
a use of an operand that has not returned from a preceding translation lookaside buffer (TLB) miss;
a use of an operand that has not returned from a preceding full or partial read-after-write (RAW) from store buffer operation; and
a use of an operand that depends on another operand that is subject to an unresolved data dependency.
19. A computer system that avoids read-after-write (RAW) hazards while speculatively executing instructions, comprising:
a processor;
a memory;
an issuing mechanism within the processor configured to issue instructions for execution during a normal execution mode; and
an execution mechanism within the processor;
wherein upon encountering a stall condition during execution of an instruction, the execution mechanism is configured to generate a checkpoint, and to execute the instruction and subsequent instructions in a speculative-execution mode, wherein the stall condition is a data-dependent stall condition, and wherein the speculative-execution mode is an execute-ahead mode, wherein instructions that cannot be executed because of an unresolved data dependency are deferred, and wherein other non-deferred instructions are executed in program order;
wherein the execution mechanism is configured to maintain dependency information for each register indicating whether or not a value in the register depends on an unresolved data-dependency; and
wherein the execution mechanism is configured to use the dependency information to avoid RAW hazards during the speculative-execution mode;
wherein if the data-dependent stall condition is resolved during execute-ahead mode, the execution mechanism is configured to execute deferred instructions in a deferred execution mode by:
issuing deferred instructions for execution in program order;
deferring execution of deferred instructions that still cannot be executed because of unresolved data dependencies:
executing other deferred instructions that are able to be executed in program order; and
if all deferred instructions are executed, to return to the normal execution mode to resume normal program execution from the point where the execute-ahead mode left off.