1. A stable oral solid dosage form comprising;
(a) cis-adamantane-2-spiro-3\u2032-8\u2032-(2\u2032-amino-2\u2032-methylpropyl)aminocarbonyl-methyl-1\u2032,2\u2032,4\u2032-trioxaspiro4.5decane hydrogen maleate (Active compound I);
(b) piperaquine; and
(c) one or more pharmaceutically acceptable excipients; wherein the dosage form is prepared by a dry process.
2. The stable oral solid dosage form according to claim 1, wherein the dosage form comprises;
(a) Active compound I in an amount of from about 5% to about 25%; and
(b) piperaquine in an amount from about 40% to about 80% ww based on the total weight of the dosage form.
3. The stable oral solid dosage form according to claim 1, wherein the pharmaceutically acceptable excipient is selected from the group consisting of binders, diluents, glidantslubricants, disintegrants, surfactants and coloring agents.
4. The stable oral solid dosage form according to claim 3, wherein the diluent is microcrystalline cellulose.
5. The stable oral solid dosage form according to claim 1, wherein the dosage form has dissolution performance such that more than 70% ww of the Active compound I dissolves within 45 minutes, in a pH 4.5 acetate buffer with 2% tween 80, in USP type II apparatus.
6. The stable oral solid dosage form according to claim 1, wherein the Active compound I and piperaquine are present in a weight ratio of from about 1:1 to about 1:10.
7. The stable oral solid dosage form according to claim 1, wherein the Active compound I is present in a dose range of about 100 mg to about 300 mg and piperaquine is present in a dose range of about 700 mg to about 850 mg.
8. The stable oral solid dosage form according to claim 1, wherein the dosage form comprises:
(a) Active compound I in an amount of from about 5% to about 25%;
(b) piperaquine in an amount of from about 40% to about 80%;
(c) diluent in an amount of from about 10% to about 40%;
(d) disintegrant in an amount of from about 1% to about 10%; and
(e) lubricant in an amount of from about 1% to about 5% ww based on the total weight of the dosage form.
9. The stable oral solid dosage form according to claim 1, wherein the dosage form comprises:
(a) Active compound I;
(b) piperaquine;
(c) microcrystalline cellulose as a diluent;
(d) crospovidone as a disintegrant; and
(e) magnesium stearate as a lubricant.
10. The stable oral solid dosage form according to claim 1, wherein the dosage form comprises:
(a) Active compound I in an amount of from about 5% to about 25%;
(b) piperaquine in an amount of from about 40% to about 80%, and
(c) microcrystalline cellulose in an amount of from about 10% to about 40% ww based on the total weight of the dosage form.
11. The stable oral solid dosage form according to claim 1, wherein the dosage form comprises Active compound I and microcrystalline cellulose in a weight ratio of from about 1:1 to about 1:5.
12. The stable oral solid dosage form according to claim 1, wherein the dosage form is selected from a group consisting of tablet, capsule, pill, granule and powder.
13. The stable oral solid dosage form according to claim 12, wherein the tablet is coated with one or more functional and or non-functional coating layers comprising film-forming polymers and coating additives.
14. The stable oral solid dosage form according to claim 13, wherein the coating additives comprise one or more of plasticizers, glidants or flow regulators, opacifiers and lubricants.
15. The stable oral solid dosage form according to claim 1, wherein the dosage form is processed and stored at a temperature below 27\xb0 C. and relative humidity 50%.
16. The stable oral solid dosage form according to claim 1, wherein the dry process comprises direct compression or dry granulation.
17. The stable oral solid dosage form according to claim 1, wherein the dosage form is prepared by a process comprising the steps of:
(a) blending Active compound I, piperaquine, and one or more intragranular excipients;
(b) milling, grinding or sieving the blend by roller compaction to form granules;
(c) blending the granules with one or more extragranular excipients;
(d) compressing the blend into tablets or filling into capsules.
18. The stable oral solid dosage form according to claim 1, wherein the dosage form is prepared by a process comprising the steps of:
(a) blending Active compound I, piperaquine, and one or more intragranular excipients;
(b) granulating the blend by slugging;
(c) blending the granules with one or more extragranular excipients;
(d) compressing the blend into tablets or filling into capsules.
19. The stable oral solid dosage form according to claim 1, wherein the dosage form is prepared is prepared by a process comprising the steps of:
(a) blending Active compound I, piperaquine, and one or more pharmaceutically acceptable excipients; and
(b) directly compressing the blend into tablets or filling into capsules.
20. The stable oral solid dosage form according to claim 1, wherein the dosage form is prepared by a process comprising the steps of:
(a) granulating a blend of one or more excipients;
(b) drying the excipient granules;
(c) blending excipient granules with Active compound I and piperaquine; and
(d) compressing the blend into tablets or filling into capsules.
21. A method of treatment of malaria, the method comprising administering a stable oral solid dosage form comprising:
(a) Active compound I;
(b) piperaquine; and
(c) one or more pharmaceutically acceptable excipients, wherein the dosage form is prepared by a dry process.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method for connecting multiple mobile devices each of which has a touch screen display, comprising:
receiving data from a first device and a second device, respectively, said data including a touch event detected by said first and second devices;
based on said received data, determining that said first and second devices are to be connected; and
generating instructions for said first and second devices to connect.
2. The method of claim 1, wherein said data further includes location and direction information of said first and second devices.
3. The method of claim 2, further comprising determining from said data whether said first and second devices are placed next to each other.
4. The method of claim 1, wherein said data further includes position and time information of said touch event.
5. The method of claim 4, further comprising:
determining from said data whether said touch event is intended to combine the screen displays of said first and second devices; and
generating instructions for said first and second devices to form a combined virtual screen display
6. The method of claim 1, further comprising connecting said first and second devices through a cloud server, wherein said first and second devices communicate with said cloud server via a communication network.
7. The method of claim 1, further comprising:
establishing connections between said first and second devices;
detecting a touch input in said first device;
sending said touch input to said second device; and
in response to said touch input, activating a display in said combined virtual screen.
8. A device comprising:
a display integrated with a touch screen, said touch screen configured to detect touch inputs in the device;
a processor coupled to said touch screen; and
a memory accessible to said processor, said memory storing processor-executable instructions, wherein said instructions, while executed, cause said processor to perform:
receiving touch information of a touch event detected in said touch screen;
sending said touch information and device information to a cloud server, said device information including at least a location of the device;
receiving instructions from said cloud server; and
based on said instructions, activating a connection mode allowing data exchange with one or more of other devices that are identified by said cloud server.
9. The device of claim 8, wherein said device information further includes an orientation of the device.
10. The device of claim 8, wherein said touch information includes at least a position of said touch event and time of said touch event.
11. The device of claim 8, said instructions, while executed, cause said processor to further perform establishing a connection between said device and other devices in communication with said cloud server.
12. The device of claim 8, wherein said connection mode includes a screen-combining mode that form a virtual screen with said display and displays of said one ore more of the other devices.
13. The device of claim 12, wherein, in said screen-combining mode, said processor is configured for:
detecting a touch input in said device; and
sending data of said touch input to said second device, wherein said virtual screen displays an image in response to said touch input.
14. A device comprising:
a display integrated with a touch screen, said touch screen configured for detecting touch inputs in the device;
a memory storing process-executable instructions; and
a processor having access to said memory, said processor configured for:
receiving first touch information of a first touch event detected in said touch screen;
receiving second touch information of a second touch event detected in a second device;
receiving device information from said second device; and
based on said first and second touch information and device information, determining whether to connect said device to said second device.
15. The device of claim 14, wherein when the first touch event and the second touch event occur simultaneously, the processor determines that said device to be connected to said second device.
16. The device of claim 14, wherein said touch information indicates a position and time of said touch event.
17. The device of claim 14, wherein said processor is further configured for determining whether said device and said second device are next to each other based on said first and second touch information and said device information.
18. The device of claim 14, wherein, when the device is determined to be connected to said second device, said processor is further configured for:
establishing connection with the second device;
forming a combined virtual screen with said display and a display of the second device;
receiving a touch input from said touch screen;
sharing said touch input with said second device; and
allowing an image to be displayed in said combined virtual screen in response to said touch input.
19. A non-transitory computer-readable medium comprising processor-executable instructions, which, while executed, cause a processor to perform:
receiving data from a first device having a first display and a second device having a second display;
based on said received data, determining to combine said first and second displays into a combined virtual screen display; and
generating instructions for said first and second devices to connect and form said combined virtual screen display,
wherein said data include a touch event detected by said first and second devices.
20. The non-transitory computer-readable medium of claim 19, wherein said processor-executable instructions, which, while executed, cause a processor to further perform:
establishing connections between said first and second devices;
detecting a touch input in said first device;
sending said touch input to said second device; and
in response to said touch input, activating a display in said combined virtual screen.