We claim:
1. A cap for a container capable of dispensing a continuous strip of wet wipes comprising:
a) an upper wall provided with a window having a contour that is extended, at least on one of the sides of the window, by a narrow slot for introducing and retaining the strip, the upper wall further having a plane, and
b) a cutting blade provided externally on the upper wall and spaced away from the narrow slot for cutting a transverse extension of the strip when the strip is pressed against the cutting blade by the user.
2. The cap of claim 1, wherein the contour of the window coincides with the contour of the narrow slot such that the strip may flow smoothly through the window when pulled by the user.
3. The cap of claim 1, wherein the narrow slot has a width dimensioned to restrain the strip from axially displacing outwardly from the container when the strip is pulled by the user.
4. The cap of claim 1 wherein the narrow slot has a longitudinal extension dimensioned to receive a whole transverse extension of the strip.
5. The cap of claim 1, wherein the cutting blade is provided on a plane substantially orthogonal to the plane of the upper wall of the cap.
6. The cap of claim 5, wherein the cutting blade has a cutting edge facing the upper wall and slightly spaced therefrom, the cutting edge further comprising a lower cutting edge.
7. The cap of claim 6, wherein the cutting edge of the cutting blade is inclined in relation to the plane of the upper wall of the cap.
8. The cap of claim 6, wherein the cutting edge of the cutting blade is laterally and superiorly covered by a material that forms the upper wall of the cap such that only the lower cutting edge is uncovered.
9. The cap of claim 1, further comprising a peripheral edge concentrically integral with the upper wall, wherein the upper wall is recessed in relation the upper peripheral edge of the cap and the cutting blade is provided below the plane of the upper peripheral edge.
10. The cap of claim 1 further comprising a peripheral edge concentrically integral with the upper wall and an overcap attached to the peripheral edge, whereby the overcap is selectively displaceable between an open position that exposes the upper wall of the cap, and a closed position that defines a chamber for lodging the cutting blade and a longitudinal extension of the strip that has been already extracted and positioned between the window and the cutting blade.
11. The cap of claim 1, wherein the strip is provided with weakened lines.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method of altering allogeneic organ tissue of a human donor for a human recipient, the method comprising:
identifying at least one mismatch in an HLA protein between the human donor and the human recipient, wherein the mismatch is a single amino acid mismatch or a plurality of mismatched amino acids in a domain of the protein, wherein the protein is a polymorphic target having at least one conserved domain, wherein the domain is at least one selected from the group consisting of MHC class I \u03b11, \u03b12, \u03b13 and the MHC class II \u03b11, \u03b21, and \u03b22;
determining a consensus conserved nucleic acid sequence among nucleic acid sequences encoding the domain having the mismatch or among domains having the plurality of mismatches, and constructing a lentivirus vector for expressing an siRNA comprising the consensus conserved nucleic acid sequence which when expressed in cells functions as a negative modulator for nucleic acid encoding the domain having the mismatch or the domains having the plurality of mismatches; and
perfusing the organ tissue of the human donor via at least in-flowing arterial vasculature of the organ tissue to contact at least some cells of the organ tissue with the lentivirus vector wherein at least some contacted cells of the organ tissue express the siRNA, wherein the vector sequence is permanently integrated into a genome of at least some of the contacted cells of the organ tissue, thereby altering and reducing immunogenicity of the organ tissue for the human recipient wherein the organ tissue of the human donor is selected from the group of: kidney, pancreas, heart, and lung.
2. The method according to claim 1, the method further comprising performing a surgical procedure on the human recipient to deliver the organ tissue of the human donor to the recipient, the method decreasing donor organ tissue immunogenicity and increasing donor organ tissue half-life in the human recipient.
3. The method according to claim 2, further comprising following the surgical procedure, observing:
the donor organ tissue having a greater lifetime in the human recipient than donor organ tissue that is otherwise identical but not similarly contacted.
4. The method according to claim 1, wherein the human recipient is in need of a transplant of organ tissue.