1. A method of diagnosing kidney injury or a kidney disease, comprising:
assaying a biological sample obtained from a subject to determine a Pacsin 2 expression level, wherein determining the Pacsin 2 expression level is by application of a reagent that reacts with Pacsin 2 or a complex comprising Pacsin 2, and wherein the reagent comprises a detectably labeled probe;
comparing the Pacsin 2 expression level to a reference level; and
diagnosing the kidney injury or a kidney disease if the Pacsin 2 expression level is higher than the reference level.
2.-25. (canceled)
26. The method of claim 1, wherein the reagent is an antibody.
27. The method of claim 1, further comprising administering a kidney therapy if the kidney injury or kidney disease is diagnosed.
28. The method of claim 1, wherein the biological sample comprises blood or urine.
29. The method of claim 1, wherein the biological sample comprises a kidney cell, kidney tissue, a brush border of a tubule of a kidney, an apical brush border of a proximal tubule of a kidney, or combinations thereof.
30. The method of claim 1, wherein the kidney injury or kidney disease is post ischemia-reperfusion injury.
31. The method of claim 1, wherein the kidney disease is polycystic kidney disease.
32. The method of claim 27, wherein the kidney therapy is selected from the group consisting of a Pacsin 2 agonist, a Pacsin 2 product, a Pacsin 2 product mimetic and combinations thereof.
33. The method of claim 32, wherein the Pacsin 2 product comprises a Pacsin 2 protein or an active fragment thereof.
34. A method of diagnosing kidney injury or a kidney disease, comprising:
assaying a biological sample obtained from a subject to determine a Pacsin 2 expression level, wherein determining the Pacsin 2 expression level is by application of a detectably labeled probe that hybridizes to a nucleic acid molecule expressed by PACSIN2 gene;
comparing the Pacsin 2 expression level to a reference level; and
diagnosing the kidney injury or a kidney disease if the Pacsin 2 expression level is higher than the reference level.
35. The method of claim 34, wherein the nucleic acid molecule is RNA.
36. The method of claim 34, further comprising amplifying the nucleic acid molecule.
37. The method of claim 34, wherein the nucleic acid molecule or an amplification product thereof is quantified using semi-quantitative RT-PCR.
38. The method of claim 34, further comprising administering a kidney therapy if the kidney injury or kidney disease is diagnosed.
39. The method of claim 34, wherein the biological sample comprises blood or urine.
40. The method of claim 34, wherein the biological sample comprises a kidney cell, kidney tissue, a brush border of a tubule of a kidney, an apical brush border of a proximal tubule of a kidney, or combinations thereof.
41. The method of claim 34, wherein the kidney injury or kidney disease is post ischemia-reperfusion injury.
42. The method of claim 34, wherein the kidney disease is polycystic kidney disease.
43. The method of claim 38, wherein the kidney therapy is selected from the group consisting of a Pacsin 2 agonist, a Pacsin 2 product, a Pacsin 2 product mimetic and combinations thereof.
44. The method of claim 43, wherein the Pacsin 2 product comprises a Pacsin 2 protein or an active fragment thereof.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A drive circuit for a switchable heating transformer (HT) of an electronic ballast with
a circuit input terminal (E) for picking up an oscillating inverter voltage, which has a variable inverter frequency, and
a switching device (S1), to whose output terminal the heating transformer (HT) is connected,
characterized by
a frequency evaluation device, which is connected downstream of the circuit input terminal (E) and with which the inverter frequency is converted into a drive signal for the switching device (S1).
2. The drive circuit as claimed in claim 1, the frequency evaluation device having a charge pump (C1, C2, D1, D2).
3. The drive circuit as claimed in claim 2, a voltage divider (R1, R2) being connected downstream of the charge pump (C1, C2, D1, D2).
4. The drive circuit as claimed in claim 3, the switching device (S1) comprising a MOSFET transistor.
5. The drive circuit as claimed in claim 2, the switching device (S1) comprising a MOSFET transistor.
6. The drive circuit as claimed in claim 1, the switching device (S1) comprising a MOSFET transistor.
7. An electronic ballast for a gas discharge lamp with a half-bridge, a load circuit, whose oscillating inverter voltage is produced at the half-bridge, and a drive circuit as claimed in claim 1.
8. The electronic ballast as claimed in claim 7, the amplitude of the oscillating inverter voltage being kept invariable.
9. A method for switching a heating transformer (HT) of an electronic ballast,
characterized by
pickup of an oscillating inverter voltage, which has a variable inverter frequency,
conversion of the inverter frequency into a drive signal, and
switching of the heating transformer (HT) as a function of the drive signal.
10. The method as claimed in claim 9, the conversion of the inverter frequency into a drive signal taking place by means of a charge pump (C1, C2, D1, D2) and in the process the amplitude of the oscillating inverter voltage being kept constant.