1. A composition for treating cyst formation associated with APKD, said composition comprising an isolated human PKD1 gene having the DNA sequence of SEQ ID NO:1, its complement, or fragments thereof, and a pharmaceutically acceptable carrier or diluent.
2. The composition of claim 1 comprising a vector into which said PKD1 gene is incorporated.
3. The composition of claim 1, wherein said isolated human PKD1 gene comprises an intronless nucleic acid sequence derived from the DNA sequence of SEQ ID NO:1, its complement or fragments thereof, wherein said intronless nucleic acid sequence is a cDNA.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A lens driving device mounted in an optical unit, the lens driving device comprising:
a lead screw to be rotated by a motor;
a movable member including a gear portion that is a rack gear portion or a half nut portion that meshes with the lead screw;
a lens holder configured to reciprocate along a rotation axis of the lead screw as the lead screw rotates, the lens holder including a spring supporting frame;
a guide shaft that extends parallel to the rotation axis, the guide shaft extending through the movable member and the spring supporting frame; and
a coil spring that is wound around the guide shaft and disposed in the spring supporting frame, the coil spring having a first end abutting against the lens holder and a second end abutting against the movable member, the coil spring pressing the gear portion against the lead screw with an urging force thereof applied to the gear portion through the second end,
wherein the guide shaft guides both of the lens holder and the movable member to reciprocate along the rotation axis, and guides the movable member to rotate therearound.
2. The lens driving device according to claim 1,
wherein the guide shaft passes through a first portion of the spring supporting frame, a second portion of the spring supporting frame facing the first portion, and the movable member,
wherein the movable member is disposed between the first portion and the second portion such that the movable member is in contact with the first portion,
wherein the coil spring is a compression coil spring, and
wherein the compression coil spring is disposed in the spring supporting frame at a position between the movable member and the second portion, the first end of the compression coil spring abutting against the spring supporting frame, and the second end of the compression coil spring abutting against the movable member.
3. The lens driving device according to claim 2, further comprising:
an anti-rotation shaft that extends parallel to the guide shaft,
wherein the lens holder includes:
an anti-rotation piece that protrudes perpendicular to the rotation axis of the lead screw, the anti-rotation piece being pressed against the anti-rotation shaft by an urging force of the compression coil spring applied to the anti-rotation piece through the first end of the compression coil spring abutting against the spring supporting frame.
4. The lens driving device according to claim 1, further comprising:
an anti-rotation shaft that extends parallel to the guide shaft,
wherein the lens holder includes:
an anti-rotation piece that protrudes perpendicular to the rotation axis of the lead screw, the anti-rotation piece being pressed against the anti-rotation shaft by an urging force of the coil spring applied to the anti-rotation piece through the first end of the coil spring abutting against the spring supporting frame.
5. The lens driving device according to claim 1, wherein the lens holder and the movable member rotate around the guide shaft in a first direction and a second direction opposite to the first direction, respectively, by respective urging forces applied thereto from the coil spring.
6. The lens driving device according to claim 1,
wherein the spring supporting frame of the lens holder includes:
a first portion;
a second portion facing the first portion; and
a connection portion connecting the first portion and the second portion,
wherein the movable member further includes a base end portion, the movable member being disposed between the first portion and the second portion such that the base end portion is in contact with the first portion,
and wherein the guide shaft passing through the first portion, the base end portion, and the second portion.
7. The lens driving device according to claim 6,
wherein the coil spring is disposed in the spring supporting frame between the base end portion and the second portion, the first end of the coil spring abutting against the second portion, and the second end of the compression coil spring abutting against the base end portion.
8. The lens driving device according to claim 6,
wherein the movable member further includes a rod portion in which the guide shaft passes, the coil spring winding around the rod portion.