1. A public network based video system having flow control, the system comprising:
a network server configured to:
send a data stream representative of an audiovisual sequence, directed to a communication device, via a public network, the audiovisual sequence including one or more temporal elements and one or more non-temporal elements;
include particular elements of the audiovisual sequence in the data stream;
send the data stream, via the public network, directed to the communication device at a data rate according to a data rate requirement;
assign a unique identifier to one of the temporal or non-temporal elements; and
transmit redirection data for the one of the temporal or non-temporal elements and the unique identifier to the communication device; and
a communication device configured to:
receive the data stream;
analyze the data stream to determine a timing of presentation of the temporal and non-temporal elements to determine the data rate requirement for a future period of time; and
send a request to the server to send the particular elements of the audiovisual sequence, the request including the data rate requirement for the requested elements
the network server further comprising a custom network server, the custom network server configured to:
receive information, according to a redirection information, indicative of the unique identifier and the data rate requirement for each of a one or more identified active data; and
include the particular elements in the data stream; and
send the data stream at the data rate according to the data rate requirement.
2. The system of claim 1 wherein the redirection information for at least two of the elements in the audiovisual sequence includes different domain name server portions of a resource locator.
3. The system of claim 1 wherein the system comprises a video editing system.
4. The system of claim 3 wherein the network server is further configured to: receive instructions to modify the elements to be included in the data stream after the data stream has begun being sent by the network server.
5. The system of claim 1 wherein the communications device comprises at least one selected from the group consisting of: a personal computer, a laptop computer, a handheld computer, a phone, and a video player.
6. The system of claim 1 wherein the public network is the Internet.
7. A public network based video system having flow control, the video system comprising:
a network server comprising a web server configured to:
send a data stream representative of an audiovisual sequence, directed to a communication device, via a public network, the audiovisual sequence including one or more temporal elements and one or more non-temporal elements;
receive information indicative of the one or more of the temporal elements and the one or more non-temporal elements of the audiovisual sequence to be sent in the data stream and a required data rate for indicated elements;
include the indicated elements in the data stream;
send the data stream, via the public network, directed to the communication device at a data rate according to the required data rate while the data stream includes the indicated elements;
assign a unique identifier to one of the temporal or non-temporal elements; and
transmit redirection data for the one of the temporal or non-temporal elements and the unique identifier to the communication device;
the network server further comprising a custom network server configured to:
receive information, according to the redirection data, indicative of the unique identifier and the data rate requirement for each of a one or more identified active data;
include the indicated elements in the data stream; and
send the data stream at a data rate according to the data rate requirement.
8. The system of claim 7 wherein the redirection information for at least two of the elements in the audiovisual sequence includes different domain name server portions of a resource locator.
9. The system of claim 8 wherein the system comprises a video editing system.
10. The system of claim 7 wherein the network server is further configured to:
receive instructions to modify the elements to be included in the data stream after the data stream has begun being sent by the network server.
11. The system of claim 7 wherein the public network is the Internet.
12. A public network video system having flow control, the system comprising:
a communication device configured to:
receive a data stream representative of an audiovisual sequence from a server via a public network, the audiovisual sequence including one or more temporal elements and one or more non-temporal elements;
analyze the data stream to determine a timing of presentation of the temporal and non-temporal elements to determine a data rate requirement for a future period of time; and
send a request to the server for transmission of particular elements of the audiovisual sequence, the request including a data rate requirement for the requested elements.
13. The system of claim 12 wherein the communication device is further configured to receive data indicative of data rates for one or more elements to be included in the data stream.
14. The system of claim 12 wherein the system comprises a video editing system.
15. The system of claim 14 wherein the communication device is further configured to: send instructions to modify the elements to be included in the data stream after the data stream has begun being received by the communication device.
16. The system of claim 12 wherein the communications device comprises at least one selected from the group consisting of: a personal computer, a laptop computer, a handheld computer, a phone, and a video player.
17. The system of claim 12 wherein the public network is the Internet.
18. A method of network based video transmission having flow control, the method comprising:
sending a data stream representative of an audiovisual sequence, from a network server directed to a communication device, via a public network, the audiovisual sequence including one or more temporal elements and one or more non-temporal elements; and
receiving the data stream by the communication device;
analyzing, by the communication device, the data stream to determine a timing of presentation of the temporal and non-temporal elements to determine a data rate requirement for a future period of time;
sending, by the communication device, a request to the server to send particular elements of the audiovisual sequence, the request including a data rate requirement for the requested elements;
including the particular elements in the data stream; and
sending the data stream, via the public network, directed to the communication device, by the server at a data rate according to the data rate requirement;
assigning a unique identifier to one of the temporal or non-temporal elements;
transmitting, by the network server, redirection data for the one of the temporal and non-temporal elements and the unique identifier to the communication device;
receiving information, by a custom network server, according to the redirection data, indicative of the unique identifier and the data rate requirement for each of a one or more identified active data;
including the particular elements in the data stream; and
sending the data stream at a data rate according to the data rate requirement.
19. The method of claim 18 wherein the redirection information for at least two of the elements in the audiovisual sequence includes different domain name server portions of a resource locator.
20. The method of claim 18 wherein the method comprises a video editing method.
21. The method of claim 20 further comprising: receiving instructions to modify the elements to be included in the data stream after the data stream has begun being sent by the network server.
22. The method of claim 18 wherein the communications device comprises at least one selected from the group consisting of: a personal computer, a laptop computer, a handheld computer, a phone, and a video player.
23. The method of claim 18 wherein the public network is the Internet.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. Use of IL-15 or active variants thereof andor IL-15 activity enhancing compounds for the manufacture of a pharmaceutical composition for manipulating memory cells of the immune system.
2. Use of IL-15 or active variants thereof andor IL-15 activity enhancing compounds according to claim 1 for manipulating viability of memory cells generated during encounter with antigen.
3. Use of IL-15 or active variants thereof andor IL-15 activity enhancing compounds according to claim 1 for manipulating responsiveness of memory cells to a new encounter with antigen.
4. Use of IL-15 or active variants thereof andor IL-15 activity enhancing compounds according to claim 1 or 2 to promote an immune response of said memory cells.
5. Use of IL-15 or active variants thereof andor IL-15 activity enhancing compounds for inducing a resting phenotype in ex vivo propagated T lymphocytes.
6. Use of IL-15 or active variants thereof andor IL-15 activity enhancing compounds for protecting ex vivo propagated T lymphocytes against cells death in absence of growth factor.
7. Use of IL-15 or active variants thereof andor IL-15 activity enhancing compounds according to claims 1 to 6 wherein the memory cells are CD4 T lymphocytes.
8. Use according to any one of the claims 1 to 7, wherein the IL-15 activity enhancing compound is lipopolysaccharide (LPS).
9. Use of IL-15 inhibiting or eliminating compounds for the manufacture of a pharmaceutical composition for manipulating memory cells of the immune system.
10. Use of IL-15 inhibiting or eliminating compounds according to claim 9 wherein the memory cells are CD4 T lymphocytes.
11. Use of IL-15 inhibiting or eliminating compounds according to claim 9 or 10 wherein said compound is selected from the group consisting of an anti-IL-15 antibody, anti-IL-15R antibody, fragments of these antibodies, e.g. the Fab or F(ab)2 fragment, soluble IL-15R, fusion proteins consisting of soluble IL-15R and Fc fragment, compounds, e.g. peptides, binding andor inhibiting functional IL-15 receptor, IL-15 antisense oligonucleotides.
12. Pharmaceutical composition comprising IL-15 or active variants thereof andor IL-15 activity enhancing compounds, optionally together with a suitable excipient.
13. Pharmaceutical composition according to claim 12 for use in manipulating memory cells of the immune system.
14. Pharmaceutical composition according to claim 12 or 13 for use in the treatment of auto-immune diseases or in treatment before, during or after transplantation.
15. Pharmaceutical composition according to claim 12, 13 and 14, wherein the IL-15 activity enhancing compound is lipopolysaccharide (LPS).
16. Pharmaceutical composition comprising IL-15 inhibiting or eliminating compounds, optionally together with a suitable excipient.
17. Pharmaceutical composition according to claim 16 for use in the repression of an immune response of memory cells of the immune system.
18. Pharmaceutical composition according to claim 16 for use in the treatment of immune deficiency diseases, or in treatment before, during or after vaccination.
19. Pharmaceutical composition according to claims 16, 17 and 18, wherein the compound is selected from the group consisting of an anti-IL-15 antibody, anti-IL-15R antibody, fragments of these antibodies, e.g. the Fab or F(ab)2 fragment, soluble IL-15R, fusion proteins consisting of soluble IL-15R and Fc fragment, compounds, e.g. peptides, binding andor inhibiting functional IL-15 receptor, IL-15 antisense oligonucleotides.
20. Pharmaceutical composition comprising ex vivo cultivated T lymphocytes, treated with IL-15 or active variants thereof andor IL-15 activity enhancing compounds.