1) A method of preparing a phospholipid delivery system for use in encapsulating bio-affecting compounds, said method comprising solubilizing a heterogeneous phospholipid mixture into a suitable organic solvent to form a concentrated formulation of phospholipids; wherein the phospholipids comprise a negatively charged phospholipid species.
2) A phospholipid delivery system for use in encapsulating bio-affecting compounds, comprising a heterogeneous phospholipid mixture, including negatively charged phospholipid species, in a suitable organic solvent.
3) A method of preparing an intermediary nanoscale particle complex (NSP) comprising the steps of:
i) solubilizing a heterogeneous phospholipid mixture in a first quantity of a non-aqueous solvent appropriate to completely solubilize phospholipids into an optically clear solution of a phospholipid delivery system;
ii) solubilizing concentrated bio-affecting compounds in an aqueous solution in an amount sufficient to produce a shelf stable solution of bio-affecting compounds to be encapsulated by the phospholipid delivery system of (i); and
iii) mixing the products of steps (i) and (ii) to produce an intermediary shelf-stable NSP complex encapsulating bio-affecting compounds, wherein the complex is in concentrated form.
4) A shelf-stable NSP complex in a concentrated form comprising:
i) a phospholipid delivery system comprising a heterogeneous phospholipid mixture, including negatively charged phospholipid species, in a suitable organic solvent;
ii) at least one concentrated bio-affecting compound in an aqueous solution; and
wherein (i) and (ii) form the concentrated intermediary shelf-stable NSP complex with the at least one bio-affecting compound encapsulated in the phospholipid delivery system.
5) A method of making an NSP complex for administration comprising the steps of:
i) solubilizing a heterogeneous phospholipid mixture in a first quantity of a non-aqueous solvent appropriate to completely solubilize phospholipids into an optically clear solution;
ii) solubilizing concentrated bio-affecting compounds in an aqueous solution in an amount sufficient to produce a shelf stable solution of bio-affecting compounds to be encapsulated by the phospholipid mixture of (i);
iii) mixing products of steps (i) and (ii) to produce a shelf stable intermediary concentrated NSP complex; and
iv) producing finished NSP complex with encapsulated bio-affecting compounds by dilution of product from step (iii) into a suitable amount of aqueous solution.
6) The method of claim 3, 4 or 5, wherein the encapsulated at least one bio-affecting compound is partially separated from bio-affecting compounds not encapsulated.
7) The method of claim 6, where separation is by centrifugation, precipitation, or exclusion chromatography.
8) The method of claim 3, 4 or 5, wherein less than 50% of the bio-affecting compound is not encapsulated in a phospholipid delivery system.
9) The method of claim 3, 4 or 5, wherein less than 20% of the bio-affecting compound is not encapsulated in a phospholipid delivery system.
10) The method of claim 3, 4 or 5, wherein less than 10% of the bio-affecting compound is not encapsulated in a phospholipid delivery system.
11) The method of claim 3, 4 or 5, wherein less than 5% of the bio-affecting compound is not encapsulated in a phospholipid delivery system.
12) An NSP complex for administration comprising a phospholipid encapsulated bio-affecting compound for administration to a subject in need thereof.
13) A phospholipid encapsulated bio-affecting compound composition manufactured by the steps of:
i) solubilizing a heterogeneous phospholipid mixture in a first quantity of a non-aqueous solvent appropriate to completely solubilize phospholipids into an optically clear solution of a phospholipid delivery system;
ii) solubilizing concentrated bio-affecting compounds in an aqueous solution in an amount sufficient to produce a shelf stable solution of bio-affecting compounds to be encapsulated by the phospholipid delivery system of (i); and
iii) mixing the products of steps (i) and (ii) to produce an intermediary shelf-stable phospholipid encapsulated bio-affecting compound composition, wherein the composition is in concentrated form.
14) A phospholipid encapsulated bio-affecting compound composition for administration to a subject in need thereof, manufactured by the steps of:
i) solubilizing a heterogeneous phospholipid mixture in a first quantity of a non-aqueous solvent appropriate to completely solubilize phospholipids into an optically clear solution;
ii) solubilizing concentrated bio-affecting compounds in an aqueous solution in an amount sufficient to produce a shelf stable solution of bio-affecting compounds to be encapsulated by the phospholipid mixture of (i);
iii) mixing products of steps (i) and (ii) to produce an intermediary shelf-stable phospholipid encapsulated bio-affecting compound composition, wherein the composition is in concentrated form; and
iv) producing a phospholipid encapsulated bio-affecting compound composition for administration by diluting the product from step (iii) into a suitable amount of aqueous solution.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A wireline survey tool for surveying deviated wells, comprising:
a nose having a rounded lower end;
a knuckle joint connected to the nose;
an instrument housing connected to the knuckle joint opposite the nose such that the nose articulates relative to the instrument housing, the instrument housing containing an electronic gauge for measuring a parameter of the well; and
each of the nose, the knuckle joint, and the instrument housing having a plurality of rollers mounted thereto that are free to roll when contact is made with inner surfaces of the well.
2. The wireline survey tool of claim 1, wherein each of the rollers comprises a circular disk mounted within a slot.
3. The wireline survey tool of claim 1, further comprising:
at least one weight bar of length greater than the knuckle joint for adding weight to the tool;
a second knuckle joint located between said at least one weight bar and the instrument housing, allowing articulation of the instrument housing relative to the weight bar; and
said at least one weight bar and the second knuckle joint each have a rollers mounted thereto that are free to roll when contact is made with inner surfaces of the well.
4. The wireline survey tool of claim 1, wherein each of the rollers is a circular disk mounted on a pin in a slot, such that the rollers are free to rotate relative to respective ones of the pins.
5. The wireline survey tool of claim 1, further comprising a cylindrical sealed cage containing the electronic gauge and located within the instrument housing.
6. The wireline survey tool of claim 1, wherein each of the rollers on the nose is a circular disk mounted on a pin in a slot such that the rollers are free to rotate relative to respective ones of the pins, the pins being perpendicular to an axis of the nose.
7. The wireline survey tool of claim 1, wherein the knuckle joint has an upper cylindrical portion and a lower cylindrical portion interconnected by a swivel that allows 360\xb0 movement of the upper and lower cylindrical portions relative to each other; and
the rollers are mounted to one of the cylindrical portions, the other cylindrical portion being free of rollers.
8. The wireline survey tool of claim 1, wherein the knuckle joint has multiple degrees of freedom in rotational flexibility.
9. The wireline survey tool of claim 1, wherein the plurality of rollers on each of the nose, the knuckle joint, and the instrument housing comprises at least three rollers on each of the nose, the knuckle joint, and the instrument housing, each of said at least three rollers being circumferentially spaced from the other two rollers in said at least three rollers.
10. A wireline survey tool for surveying deviated wells, comprising:
a nose;
a plurality of knuckle joints for enhancing articulation of the tool;
a plurality of weight bars, each having a length greater than a length of one of the knuckle joints for adding weight to the tool;
an instrument housing connected to the knuckle joint opposite the nose such that the nose articulates relative to the instrument housing, the instrument housing containing a temperature or pressure gauge for measuring an associated parameter of wells; and
each of the nose, the knuckle joints, the weight bars, and the instrument housing having a plurality of circumferentially spaced apart wheels mounted thereto for longitudinal rolling movement in wells.
11. The wireline survey tool of claim 10, wherein a knuckle joint is located between adjacent ones of the weight bars.
12. The wireline survey tool of claim 10, wherein a knuckle joint is located between a lowermost one of the weight bars and the instrument housing.
13. The wireline survey tool of claim 10, wherein a knuckle joint is located between the instrument housing and the nose.
14. The wireline survey tool of claim 10, wherein each of the wheels is a flat circular disk mounted on a pin in a slot such that the wheels are free to rotate relative to respective ones of the pins.
15. The wireline survey tool of claim 10, further comprising a cylindrical sealed cage containing the temperature or pressure gauge and located within the instrument housing.
16. The wireline survey tool of claim 10, wherein each of the wheels on the nose is a circular disk mounted on a pin in a slot such that the wheels are free to rotate relative to respective ones of the pins, the pins being perpendicular to an axis of the nose.
17. The wireline survey tool of claim 10, wherein each of the knuckle joints has an upper cylindrical portion and a lower cylindrical portion interconnected by a swivel that allows 360\xb0 movement of the upper and lower cylindrical portions relative to each other; and
the wheels are mounted to one of the cylindrical portions, the other cylindrical portion being free of wheels.
18. The wireline survey tool of claim 10, wherein the knuckle joint has multiple degrees of freedom in rotational flexibility.
19. A method of surveying a well, comprising:
providing a wireline survey tool with a nose, an instrument housing containing an electronic gauge for measuring a parameter of the well, and a knuckle joint between the nose and the instrument housing;
mounting a plurality of rollers to each of the nose, the knuckle joint, and the instrument housing and configuring each of the rollers as a circular disk mounted within a slot;
lowering the wireline survey tool into the well such that the nose articulates relative to the instrument housing via the knuckle joint;
contacting inner surfaces of the well with the rollers and rolling the rollers relative to the wireline survey tool to facilitate deeper movement of the wireline survey tool into the well; and then
taking a measurement in the well with the electronic gauge.
20. The method of claim 19, further comprising:
adding at least one weight bar of length greater than the knuckle joint for additional weight for the wireline survey tool;
positioning a second knuckle joint between said at least one weight bar and the instrument housing to allow articulation of the instrument housing relative to the weight bar; and
configuring said at least one weight bar and the second knuckle joint with rollers that contact and roll against inner surfaces of the well.
21. The method of claim 19, further comprising configuring each of the rollers as a circular disk and mounting each of the rollers on a pin in a slot such that the rollers rotate relative to respective ones of the pins.
22. The method of claim 19, further comprising mounting the electronic gauge in a cylindrical sealed cage that is located within the instrument housing.
23. The method of claim 19, further comprising configuring each of the rollers on the nose as a circular disk mounted on a pin in a slot, such that the rollers rotate relative to respective ones of the pins, and the pins are perpendicular to an axis of the nose.
24. The method of claim 19, further comprising configuring the knuckle joint with an upper cylindrical portion and a lower cylindrical portion interconnected by a swivel that allows 360\xb0 movement of the upper and lower cylindrical portions relative to each other; and
mounting the rollers to one of the cylindrical portions, the other cylindrical portion being free of rollers.
25. The method of claim 19, further comprising configuring the knuckle joint with multiple degrees of freedom in rotational flexibility.
26. The method of claim 19, further comprising configuring the plurality of rollers on each of the nose, the knuckle joint, and the instrument housing with at least three rollers on each of the nose, the knuckle joint, and the instrument housing, each of said at least three rollers being circumferentially spaced from the other two rollers of said at least three rollers.