1. An audio, comprising:
a sleeve having
a first opening formed in an axial direction thereof,
a second opening formed in a radial direction thereof and communicating the first opening, and
an inner space communicating both of said first opening and said second opening;
a supporting platform extending outwardly from one side of said sleeve, wherein said supporting platform is spaced away from said second opening, said supporting platform having a groove communicating outside, an extending direction of said groove being substantially orthogonal to an extending direction of said second opening;
a plug assembly coupled to said sleeve, having
a plug having a contact portion and a soldering portion, and
a rotatory base rotatably coupled into said second opening of said sleeve, said soldering portion being received in said rotatory base, said contact portion being capable of entering into or departing from said groove under said rotatory base rotating;
a female connector having an opening and received in said inner space of said sleeve, the opening being surrounded by said first opening of said sleeve; and
a cable interconnecting said soldering portion and said female connector.
2. The plug adapter as claimed in claim 1, wherein said plug of said plug assembly is an audio plug, said female connector is an audio female connector.
3. The plug adapter as claimed in claim 1, wherein the inner space of said sleeve comprises a first portion communicating said first opening and receiving said female connector therein, and a second portion communicating said first portion and said second opening, the width of said second opening is smaller than that of said second portion of said inner space.
4. The plug adapter as claimed in claim 3, wherein said rotatory base comprises a base portion, a head portion and a neck portion sandwiched between said base portion and said head portion, said soldering portion is received in said base portion, said neck portion and said head portion are rotatably received in said second opening and said second portion respectively, while said neck portion and said head portion are perpendicular to said plug.
5. The plug adapter as claimed in claimed 4, wherein an aperture is defined in both said neck portion and said head portion, and one end of said cable is passed through said aperture and soldered to said soldering portion of said plug of said plug assembly.
6. The plug adapter as claimed in claim 5, further comprising a position means arranged between said sleeve and said plug assembly.
7. The plug adapter as claimed in claim 6, wherein said position means has a first positioning mechanism arranged at the periphery of said second opening of said sleeve, and a second positing mechanism arranged at the periphery of said neck portion of said rotatory base of said plug assembly.
8. The plug adapter as claimed in claim 7, wherein said first positioning mechanism has a first matching surface formed on said sleeve and surrounding said second opening, and a plurality of cavities formed on said first matching surface, said second positioning mechanism having a second matching surface corresponding to said first matching surface of said first position mechanism, and a plurality of projections formed on said second matching surface and corresponding to said cavities of said first position mechanism, and said neck portion formed on said second matching surface of the second positioning mechanism.
9. An Audio, comprising:
a sleeve having
a side surface,
a first coupling means formed on said side surface,
an inner space formed in the sleeve,
a supporting platform extending outwardly on said side surface and spaced away from said first coupling means, and
a groove formed in said supporting platform and penetrated to an outer surface of said supporting platform, an extending direction of said groove substantially being orthogonal to an extending direction of said second opening;
a plug assembly coupled to said sleeve, having
a rotatory base having a second coupling means which is rotatably coupled to said first coupling means of said sleeve,
a plug having a contact portion capable of entering into or departing from said groove under said rotatory base rotating, and a soldering portion received in said rotatory base, which is perpendicular to said second coupling means of said rotatory base;
a female connector received in said inner space of said sleeve; and
a cable interconnecting said soldering portion of said plug of said plug assembly and said female connector, one part of said cable being received in said sleeve while the other part of said cable being received in said rotatory base.
10. The plug adapter as claimed in claim 9, wherein said plug of said plug assembly is an audio plug, and said female connector is an audio female connector.
11. The plug adapter as claimed in claim 9, wherein said first coupling means has an opening opened on said side surface of said sleeve, a coupling space formed in said sleeve and interconnecting said inner space and said opening, and the width of said opening is smaller than said width of said coupling space.
12. The plug adapter as claimed in claim 11, wherein said second coupling means has a neck portion formed on said rotatory base and a head portion formed on said neck portion, said head portion and said neck portion are rotatably received in said coupling space and said opening of said first coupling means of said sleeve respectively.
13. The plug adapter as claimed in claim 12, further comprising a position means arranged between said sleeve and said plug assembly.
14. The plug adapter as claimed in claim 13, wherein said position means has a first positioning mechanism arranged at the periphery of said first coupling means, and a second positing mechanism arranged at the periphery of said second coupling means.
15. The plug adapter as claimed in claim 14, wherein said first positioning mechanism has a first matching surface formed on said sleeve, and a plurality of cavities formed on said first matching surface.
16. The plug adapter as claimed in claim 15, wherein said second positioning mechanism has a second matching surface corresponding to said first matching surface of said first position mechanism, and a plurality of projections is formed on said second matching surface and corresponds to said cavities of said first position mechanism.
17. The plug adapter as claimed in claim 16, wherein said neck portion of said second coupling means is formed on said second matching surface, and said opening of said first coupling means is opened on said first matching surface of said first positioning mechanism.
18. A method for manufacturing an audio plug adapter, comprising:
soldering one end of a cable to a soldering portion of a plug;
injection-molding said plug and said cable with a first resin to form a plug assembly, wherein said first resin is molded to form a rotatory base of said plug assembly which encloses said soldering portion of said plug and said end of said cable;
soldering the other end of said cable to a female connector; and
injection-molding said plug assembly, said cable and said female connector with a second resin, wherein said second resin is molded to form a sleeve which encloses said female connector, said cable and a port of said rotatory base of said plug assembly;
wherein said first resin and said second resin are different from each other.
19. The method as claimed in claim 18, wherein said first resin is polypropylene and said second resin is thermoplastic elastomer.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
We claim:
1. A method of diagnosing cancer, tumor progression, hyperproliferative cell growth or accompanying biological and physical manifestations comprising:
(a) providing a polynucleotide probe that comprises a sequence capable of hybridizing to any one of the sequences shown in SEQ ID NO:1-339 or complement thereof;
(b) contacting a biological sample for diagnosis with said probe under hybridizing conditions that permit formation of a duplex; and
(c) determining the presence of said duplex.
2. The method of claim 1, wherein said polynucleotide probe comprises at least eight contiguous nucleotides of any of SEQ ID NO:1-339 or complement thereof.
3. The method of claim 2, wherein said polynucleotide probe comprises 8 contiguous nucleotides of the sequences of the clones selected from the group consisting of SL-5, SL-6, SL-9, SL-11, SL-13, SL-68, SL-69, SL-86, SL-90, SL-10O, SL-107, SL-124, SL-135, SL-139, SL-143, SL-152, SL-153, SL-173, SL-177, SL-195, and SL-197.
4. A method of diagnosing cancer, tumor progression, or hyper-proliferative cell growth comprising.
(a) providing an antibody capable of binding to a polypeptide encoded by any one of SEQ ID NO:1-339 or complement thereof;
(b) contacting a biological sample for diagnosis with said antibody under binding conditions that permit formation of an antibody-polypeptide complex; and
(c) determining the presence of said complex.
5. The method of claim 4, wherein said antibody is capable of binding to a polypeptide comprising at least six contiguous amino acid of a polypeptide encoded by any one of SEQ ID NO:1-339 or complement thereof.
6. The method of claim 5, wherein said polypeptide comprises at least six contiguous amino acids of a polypeptide encoded by any one the sequences of the clones selected from the group consisting of SL-5, SL-6, SL-9, SL-1 1, SL-13, SL-68, SL-69, SL-86, SL-90, SL-100, SL-107, SL-124, SL-135, SL-139, SL-143, SL-152, SL-153, SL-173, SL-177, SL-195, and SL-197.
7. A diagnostic kit comprising:
(a) a diagnostic reagent comprising a polynucleotide probe that comprises a sequence capable of hybridizing to any one of SEQ ID NO:339 or complement thereof when said sequence is present in a test biological sample;
(b) a normal biological sample; and
(c) instructions for detecting differences that exist between the levels of duplexes in said test biological sample as compared to said normal biological sample.
8. A method of treating a mammal with cancer, tumor progression, hyperproliferative cell growth or accompanying biological and physical manifestations, said method comprising administering to said mammal a composition that comprises a therapeutically effective amount of a polynucleotide comprising a sequence capable of hybridizing under stringent conditions to any one of SEQ ID NO:1-339 or complement thereof.
9. The method of claim 8, wherein said polynucleotide comprises at least eight contiguous nucleotides of any of SEQ ID NO:1-339 or complement thereof.
10. The method of claim 9, wherein said polynucleotide is an antisense construct.
11. The method of claim 9, wherein said polynucleotide is a ribozyme construct.
12. An isolated polynucleotide selected from the group consisting of
(a) a polynucleotide comprising the nucleotide sequence of any one of SEQ ID NO:2, 5, 49, 50, 99, 100, 115, 116, 118, 130, 131, 140, 144, 145, 146, 157, 158, 159, 163, 164, 165, 166, 177, 178, 180, 211, 212, 213, 218, 219, 220, 221, 229, 232, 233, 242, 243, 248, 249, 254, 256, 257, 259, 272, 273, 277, 288, 289, 292, 293, 316, 317, and 330;
(b) a polynucleotide encoding a variant of the polypeptide encoded by (a); and
(c) a polynucleotide encoding a protein expressed by a polynucleotide having the sequence of at least one of sequences of (a).
13. A vector comprising the polynucleotide of claim 12.
14. A host cell comprising the vector of claim 13.
15. A composition comprising a polypeptide, wherein the polypeptide is selected from the group consisting of:
(a) a polypeptide encoded by any one of the polynucleotides of claim 12, and
(b) a variant of the polypeptide of (a).