1. A composition comprising one or more compounds of Formula I in an amount effective for improving blood glucose control in a subject with abnormal glucose tolerance and metabolism in need of such treatment, where the compounds of Formula I have the following structure:
wherein,
each bond indicated by a dashed line can independently be double or single;
R1, R2, R3 are independently of each other hydrogen, (C1-C6)alkyl or (C1-C6)alkoxy; and
m is an integer of 0 to 12 inclusive;
or any stereoisomer, mixture of stereoisomers, prodrug, metabolite, salt, crystalline form, non-crystalline form, hydrate or solvate thereof.
2. position according to claim 1, comprising one or more compounds of Formula I selected from alpha-tocotrienol quinone, beta-tocotrienol quinone, gamma-tocotrienol quinone, and delta-tocotrienol quinone, or any stereoisomer, or mixture of stereoisomers thereof.
3. The composition according to claim 1, comprising alpha-tocotrienol quinone or any stereoisomer, or mixture of stereoisomers thereof.
4. A composition comprising one or more compounds of Formula I according to claim 1, in an amount effective for preventing, reducing, ameliorating or treating diabetes, or to stabilize the level of blood sugar, stop the increase in level of blood sugar, reverse the increase in the level of blood sugar, or reduce the level of blood sugar in a subject with abnormal glucose tolerance and metabolism in need of such treatment.
5. position according to claim 4, comprising one or more compounds of Formula I selected from alpha-tocotrienol quinone, beta-tocotrienol quinone, gamma-tocotrienol quinone, and delta-tocotrienol quinone or any stereoisomer, or mixture of stereoisomers thereof.
6. The composition according to claim 5, comprising alpha-tocotrienol quinone, or any stereoisomer, or mixture of stereoisomers thereof.
7. A composition comprising one or more compounds of Formula I according to claim 1, in an amount effective for preventing or treating a condition requiring increasing insulin sensitivity or reducing insulin resistance in a subject with abnormal glucose tolerance and metabolism in need of such treatment.
8. The composition according to claim 7, comprising one or more compounds of Formula I selected from alpha-tocotrienol quinone, beta-tocotrienol quinone, gamma-tocotrienol quinone, and delta-tocotrienol quinone or any stereoisomer, or mixture of stereoisomers thereof.
9. The composition according to claim 8, comprising alpha-tocotrienol quinone, or any stereoisomer, or mixture of stereoisomers thereof.
10. A composition comprising one or more compounds of Formula I according to claim 1, in an amount effective for preventing, reducing, ameliorating or treating vascular disease complications, including retinopathy and nephropathy, in a subject with abnormal glucose tolerance and metabolism in need of such treatment.
11. The composition according to claim 10, comprising one or more compounds of Formula I selected from alpha-tocotrienol quinone, beta-tocotrienol quinone, gamma-tocotrienol quinone, and delta-tocotrienol quinone or any stereoisomer, or mixture of stereoisomers thereof.
12. The composition according to claim 11, comprising alpha-tocotrienol quinone, or any stereoisomer, or mixture of stereoisomers thereof.
13. A composition comprising one or more compounds of Formula I according to claim 1, in an amount effective for preventing, reducing, ameliorating or treating inflammation in a subject with abnormal glucose tolerance and metabolism in need of such treatment.
14. The composition according to claim 13, comprising one or more compounds of Formula I selected from alpha-tocotrienol quinone, beta-tocotrienol quinone, gamma-tocotrienol quinone, and delta-tocotrienol quinone or any stereoisomer, or mixture of stereoisomers thereof.
15. The composition according to claim 14, comprising alpha-tocotrienol quinone, or any stereoisomer, or mixture of stereoisomers thereof.
16. A formulation comprising one or more compounds of Formula I according to claim 1, and, optionally, a pharmaceutically acceptable carrier, diluent or excipient, in an amount effective for improving blood glucose control in a subject with abnormal glucose tolerance and metabolism in need of such treatment.
17. A formulation comprising one or more compounds of Formula I according to claim 1, and, optionally, a pharmaceutically acceptable carrier, diluent or excipient, in an amount effective for preventing, reducing, ameliorating or treating diabetes, or to stabilize the level of blood sugar, stop the increase in level of blood sugar, reverse the increase in the level of blood sugar, or reduce the level of blood sugar in a subject with abnormal glucose tolerance and metabolism in need of such treatment.
18. A formulation comprising one or more compounds of Formula I according to claim 1, and, optionally, a pharmaceutically acceptable carrier, diluent or excipient, in an amount effective for preventing or treating a condition requiring increasing insulin sensitivity or reducing insulin resistance in a subject with abnormal glucose tolerance and metabolism in need of such treatment.
19. A formulation comprising one or more compounds of Formula I according to claim 1, and, optionally, a pharmaceutically acceptable carrier, diluent or excipient, in an amount effective for preventing, reducing, ameliorating or treating vascular disease complications, including retinopathy and nephropathy, in a subject with abnormal glucose tolerance and metabolism in need of such treatment.
20. A formulation comprising one or more compounds of Formula I according to claim 1, and, optionally, a pharmaceutically acceptable carrier, diluent or excipient, in an amount effective for preventing or treating inflammation in a subject with abnormal glucose tolerance and metabolism in need of such treatment.
21. A method for improving blood glucose control in a subject with abnormal glucose tolerance and metabolism in need of such treatment which comprises administering an effective amount of one or more compounds of Formula I of claim 1 and, optionally, a pharmaceutically acceptable carrier, diluent or excipient.
22. The method according to claim 21, comprising administering an effective amount of one or more compounds of Formula I selected from alpha-tocotrienol quinone, beta-tocotrienol quinone, gamma-tocotrienol quinone, and delta-tocotrienol quinone, or any stereoisomer, or mixture of stereoisomers thereof.
23. The method according to claim 22, comprising administering an effective amount of alpha-tocotrienol quinone, or any stereoisomer, or mixture of stereoisomers thereof.
24. A method for preventing, reducing, ameliorating or treating diabetes, or to stabilize the level of blood sugar, stop the increase in level of blood sugar, reverse the increase in the level of blood sugar, or reduce the level of blood sugar in a subject with abnormal glucose tolerance and metabolism in need of such treatment, which comprises administering an effective amount of one or more compounds of Formula I of claim 1 and, optionally, a pharmaceutically acceptable carrier, diluent or excipient.
25. The method according to claim 24, comprising administering an effective amount of one or more compounds of Formula I selected from alpha-tocotrienol quinone, beta-tocotrienol quinone, gamma-tocotrienol quinone, and delta-tocotrienol quinone, or any stereoisomer, or mixture of stereoisomers thereof.
26. The method according to claim 25, comprising administering an effective amount of alpha-tocotrienol quinone, or any stereoisomer, or mixture of stereoisomers thereof.
27. A method for preventing or treating a condition requiring increasing insulin sensitivity or reducing insulin resistance in a subject with abnormal glucose tolerance and metabolism in need of such treatment which comprises administering an effective amount of one or more compounds of Formula I and, optionally, a pharmaceutically acceptable carrier, diluent or excipient according to claim 1.
28. The method according to claim 27, comprising administering an effective amount of one or more compounds of Formula I selected from alpha-tocotrienol quinone, beta-tocotrienol quinone, gamma-tocotrienol quinone, and delta-tocotrienol quinone, or any stereoisomer, or mixture of stereoisomers thereof.
29. The method according to claim 28, comprising administering an effective amount of alpha-tocotrienol quinone, or any stereoisomer, or mixture of stereoisomers thereof.
30. A method for preventing, reducing, ameliorating or treating vascular disease complications of diabetes, including retinopathy and nephropathy, in a subject with abnormal glucose tolerance and metabolism in need of such treatment, which comprises administering an effective amount of one or more compounds of Formula I of claim 1, and, optionally, a pharmaceutically acceptable carrier, diluent or excipient.
31. The method according to claim 30, comprising administering an effective amount of one or more compounds of Formula I selected from alpha-tocotrienol quinone, beta-tocotrienol quinone, gamma-tocotrienol quinone, and delta-tocotrienol quinone, or any stereoisomer, or mixture of stereoisomers thereof.
32. The method according to claim 31, comprising administering an effective amount of alpha-tocotrienol quinone, or any stereoisomer, or mixture of stereoisomers thereof.
33. A method for preventing, reducing, ameliorating or treating inflammation in a subject with abnormal glucose tolerance and metabolism in need of such treatment, which comprises administering an effective amount of one or more compounds of Formula I of claim 1, and, optionally, a pharmaceutically acceptable carrier, diluent or excipient.
34. The method according to claim 33, comprising administering an effective amount of one or more compounds of Formula I selected from alpha-tocotrienol quinone, beta-tocotrienol quinone, gamma-tocotrienol quinone, and delta-tocotrienol quinone, or any stereoisomer, or mixture of stereoisomers thereof.
35. The method according to claim 34, comprising administering an effective amount of alpha-tocotrienol quinone, or any stereoisomer, or mixture of stereoisomers thereof.
36. The method of claim 21, wherein the formulation is administered orally or enterally.
37. The method of claim 24, wherein the formulation is administered orally or enterally.
38. The method of claim 27, wherein the formulation is administered orally or enterally.
39. The method of claim 30, wherein the formulation is administered orally or enterally.
40. The method of claim 33, wherein the formulation is administered orally or enterally.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A liquid container including a liquid chamber, comprising:
a light emitter;
an electrical contact configured to receive a signal for causing the light emitter to emit light;
a display portion configured to direct the light emitted from the light emitter toward an outside of the liquid container to display information about states of the liquid container;
a latch lever elastically deformable and having a latching portion spaced from a first side of the liquid container, the first side being positioned between the latching portion and the liquid chamber; and
a liquid supply port disposed at a second side of the liquid container,
wherein the electrical contact is disposed at a position which is between the latching portion and the liquid supply port when the liquid container is viewed in a direction perpendicular to the second side and which is between the latching portion and the second side when the liquid container is viewed in a direction perpendicular to the first side, and
wherein the display portion is disposed adjacent to an upper portion, in use, of the first side.
2. A liquid container according to claim 1, wherein the electrical contact is inclined relative to the first and second sides.
3. A liquid container according to claim 1, further comprising a substrate provided with the light emitter and the electrical contact and disposed on an inclined portion which is inclined relative to the first and second sides,
wherein the substrate is inclined relative to the first and second side.
4. A liquid container according to claim 1, further comprising a controller (i) storing container discrimination information indicative of a color of liquid in the liquid container, and (ii) configured to control the light emitter based on the container discrimination information and color information indicated by the signal supplied from the electrical contact.
5. A liquid container according to claim 1, further comprising a light guide portion configured to guide the light emitted from the emitter to the display portion.
6. A liquid container according to claim 5, wherein a part of the light guide portion constitutes the display portion.
7. A liquid container according to claim 1, further comprising a projection provided on a third side of the liquid container which is opposed to the first side and which provides a rotational center of the liquid container during a mounting operation of the liquid container.
8. A liquid container according to claim 1, wherein the liquid container contains liquid usable for inkjet printing in the liquid chamber.
9. A liquid container according to claim 1, wherein the position of the electrical contact is at a corner region which is between the first side and the second side and which is inclined to the first side and the second side.
10. A liquid container according to claim 1, wherein the states of the liquid container includes at least one of states relating to an amount of liquid in the liquid container and states relating to a mounting position of the liquid container.
11. A liquid container including a liquid chamber, comprising:
a light emitter;
an electrical contact;
a controller (i) storing container discrimination information indicative of a color of liquid in the liquid container, and (ii) configured (ii-a) to receive a command for causing the light emitter to emit light and color information received via the electrical contact and (ii-b) to cause the light emitter to emit light in response to the received command if the received color information corresponds to the stored container discrimination information;
a display portion configured to direct the light toward an outside of the liquid container to display information about states of the liquid container;
a light guide portion having a light incident portion on which the light emitted from the light emitter is incident and the display portion, the light guide portion being configured to guide the light from the light incident portion to the display portion;
a latch lever elastically deformable and having a latching portion spaced from a first side of the liquid container, the first side being positioned between the latching portion and the liquid chamber; and
a liquid supply port disposed at a second side of the liquid container,
wherein the electrical contact is inclined relative to the first and second sides at a position which is between the latching portion and the liquid supply port when the liquid container is viewed in a direction perpendicular to the second side and which is between the latching portion and the second side when the liquid container is viewed in a direction perpendicular to the first side, and
wherein the display portion is disposed adjacent to an upper portion, in use, of the first side.
12. A liquid container according to claim 11, wherein the controller causes the light emitter to emit light in response to the received command if the received color information is the same as the stored container discrimination information.
13. A liquid container according to claim 11, wherein the states of the liquid container includes at least one of states relating to an amount of the liquid in the liquid container and states relating to a mounting position of the liquid container.
14. A liquid container including a liquid chamber, comprising:
a latch lever elastically deformable and having a latching portion spaced from a first side of the liquid container, the first side being positioned between the latching portion and the liquid chamber;
a light emitter;
a light guide member having a first portion on which the light emitted from the light emitter is incident and a second portion configured to direct the light from the first portion toward the latch lever to notify information about states of the liquid container through the latch lever, the light guide member being configured to guide the light from the first portion to the second portion;
a liquid supply port disposed at a second side of the liquid container; and
an electrical contact configured to receive a signal for causing the light emitter to emit light, the electrical contact being inclined relative to the first and second sides at a position which is between the latching portion and the liquid supply port when the liquid container is viewed in a direction perpendicular to the second side and which is between the latching portion and the second side when the liquid container is viewed in a direction perpendicular to the first side.
15. A liquid container according to claim 14, wherein the latch lever has an operating portion which is manipulatable by a user and which is positioned at a free end of the latch lever, and
wherein the light emitted from the second portion of the light guide member passes through the operating portion of the latch lever.
16. A liquid container according to claim 14, wherein the second portion is positioned between the first side and the latching portion when the liquid container is viewed in the direction perpendicular to the second side.
17. A liquid container according to claim 14, wherein the light guide member is positioned between the first side and the latch lever when the liquid container is viewed in the direction perpendicular to the second side.
18. A liquid container according to claim 17, wherein the light guide member is spaced from the first side.
19. A liquid container according to claim 14, further comprising a substrate provided with the light emitter and the electrical contact and disposed on an inclined portion which is inclined relative to the first and second sides,
wherein the substrate is inclined relative to the first and second side.
20. A liquid container according to claim 14, further comprising a controller (i) storing container discrimination information indicative of a color of liquid in the liquid container, and (ii) configured to control the light emitter based on the container discrimination information and color information indicated by the signal supplied from the electrical contact.
21. A liquid container according to claim 14, wherein the liquid container contains liquid usable for inkjet printing in the liquid chamber.
22. A liquid container according to claim 14, wherein the position is in a corner region which is between the first side and the second side and which is inclined to the first side and the second side.
23. A liquid container according to claim 14, wherein the states of the liquid container includes at least one of states relating to an amount of the liquid in the liquid container and states relating to a mounting position of the liquid container.
24. A liquid container including a liquid chamber, comprising:
a light emitter positioned outside of the liquid chamber;
a latch lever elastically deformable;
a light guide member having (i) a first portion on which the light emitted from the light emitter is incident, and (ii) a second portion configured to direct the light from the first portion toward the latch lever to notify information about states of the liquid container through the latch lever, the light guide member being configured to guide the light from the first portion to the second portion.
25. A liquid container according to claim 24, wherein the light guide member is positioned between the liquid chamber and the latch lever when the liquid container is viewed in a direction perpendicular to a bottom side of the liquid container.
26. A liquid container according to claim 25, wherein the latch lever has an operating portion which is manipulatable by an user and which is positioned at a free end of the latch lever, and
wherein the light emitted from the second portion of the light guide member passes through the operating portion of the latch lever.
27. A liquid container according to claim 25, further comprising:
an electrical contact positioned outside of the liquid chamber and configured to receive a signal for causing to the light emitter to emit light;
a liquid supply port disposed at the bottom side,
wherein the electrical contact is inclined relative to the bottom side at a position which is between the latching portion and the liquid supply port when the liquid container is viewed in the direction perpendicular to the bottom side and which is between the latching portion and the bottom side when the liquid container is viewed in a direction parallel to the bottom side.
28. A liquid container according to claim 24, wherein the states of the liquid container includes at least one of states relating to an amount of the liquid in the liquid container and states relating to a mounting position of the liquid container.
29. A liquid container including a liquid chamber, comprising:
a light emitter positioned outside of the liquid chamber;
an electrical contact positioned outside of the liquid chamber;
a controller (i) positioned outside of the liquid chamber, (ii) storing container discrimination information indicative of a color of liquid in the liquid chamber, and (iii) configured (iii-a) to receive a command for causing the light emitter to emit light and color information via the electrical contact, and (iii-b) to cause the light emitter to emit light in response to the received command if the received color information corresponds to the stored container discrimination information;
a latch lever elastically deformable and having a latching portion spaced from a first side of the liquid container, the first side being positioned between the latching portion and the liquid chamber;
a light guide member (i) spaced from the first side, and (ii) having (ii-a) a first portion on which the light emitted from the light emitter is incident, and (ii-b) a second portion configured to direct the light from the first portion toward the latch lever to notify information about states of the liquid container through the latch lever, the light guide member being configured to guide the light from the first portion to the second portion; and
a liquid supply port disposed at a second side of the liquid container,
wherein the light guide member is positioned between the latch lever and the first side when the liquid container is viewed in a direction perpendicular to the second side.
30. A liquid container according to claim 29, wherein the controller causes the light emitter to emit light in response to the received command if the received color information is the same as the stored container discrimination information.
31. A liquid container according to claim 30, wherein the electrical contact is inclined relative to the first and second sides at a position which is between the latching portion and the liquid supply port when the liquid container is viewed in the direction perpendicular to the second side and which is between the latching portion and the second side when the liquid container is viewed in a direction perpendicular to the first side.
32. A liquid container according to claim 29, wherein the states of the liquid container includes at least one of states relating to an amount of the liquid in the liquid container and states relating to a mounting position of the liquid container.
33. A liquid container including a liquid chamber, comprising:
a light emitter positioned outside of the liquid chamber;
an electrical contact positioned outside of the liquid chamber;
a controller (i) positioned outside of the liquid chamber, (ii) storing container discrimination information indicative of a color of liquid in the liquid chamber, and (iii) configured (iii-a) to receive a command for causing the light emitter to emit light and color information via the electrical contact, and (iii-b) to cause the light emitter to emit light in response to the received command if the received color information corresponds to the stored container discrimination information;
a latch lever elastically deformable and having a latching portion spaced from a first side of the liquid container, the first side being positioned between the latching portion and the liquid chamber;
a light guide member (i) spaced from the first side, and (ii) having (ii-a) a first portion on which the light emitted from the light emitter is incident, and (ii-b) a second portion configured to direct the light from the first portion toward an outside of the liquid container to notify information about states of the liquid container, the light guide member being configured to guide the light from the first portion to the second portion; and
a liquid supply port disposed at a second side of the liquid container,
wherein the light guide member is positioned between the latch lever and the first side when the liquid container is viewed in a direction perpendicular to the second side.
34. A liquid container according to claim 33, wherein the controller causes the light emitter to emit light in response to the received command if the received color information is the same as the stored container discrimination information.
35. A liquid container according to claim 34, wherein the electrical contact is inclined relative to the first and second sides at a position which is between the latching portion and the liquid supply port when the liquid container is viewed in the direction perpendicular to the second side and which is between the latching portion and the second side when the liquid container is viewed in a direction perpendicular to the first side.
36. A liquid container according to claim 33, wherein the states of the liquid container includes at least one of states relating to an amount of the liquid in the liquid container and states relating to a mounting position of the liquid container.