1. An isolated functional fragment of a monoclonal antibody or a humanized form thereof, wherein the monoclonal antibody specifically binds Kaposi’s sarcoma-associated herpesvirus (KSHV) interleukin-6 (vIL-6), wherein the monoclonal antibody is produced by a hybridoma deposited as American Type Culture Collection (ATCC) Deposit No. PTA-2217, PTA-2218, PTA-2219, or PTA-2220.
2. The isolated functional fragment of claim 1, wherein the monoclonal antibody is a humanized form of the hybridoma deposited as American Type Culture Collection (ATCC) Deposit No. PTA-2217, PTA-2218, PTA-2219, or PTA-2220.
3. The isolated functional fragment of claim 1, wherein the functional fragment is labeled.
4. The isolated functional fragment of claim 3, wherein the label is a radiolabel, a fluorescent label, a colorimetric label, or a luminescent label.
5. The isolated functional fragment of claim 2, wherein the functional fragment is a Fab, Fab\u2032, (Fab\u2032)2, Fv or a single chain fragment.
6. A method for diagnosing or determining the prognosis of an infection of a subject with a Kaposi’s sarcoma-associated herpesvirus (KSHV), comprising
contacting a sample from the subject with the isolated functional fragment of claim 1, and
detecting the binding of the monoclonal antibody with the sample,
wherein binding of the monoclonal antibody to the sample is indicative of the diagnosis or prognosis of the infection of the subject with KSHV.
7. The method of claim 6 wherein the subject has a Kaposi’s sarcoma-associated herpes virus (KSHV) associated disorder.
8. The method of claim 6 wherein the disorder is primary effusion lymphoma, Castleman’s disease, or Kaposi’s sarcoma.
9. The method of claim 6, wherein the monoclonal antibody is labeled.
10. A method of detecting Kaposi’s sarcoma-associated herpesvirus (KSHV) interleukin-6 (vIL-6) in a biological sample, comprising
contacting the biological sample with the functional fragment of the monoclonal antibody of claim 1; and
detecting binding of the functional fragment of the monoclonal antibody to KSHV vIL-6;
thereby detecting the presence of KSHV vIL-6 in the sample.
11. The method of claim 10, wherein the functional fragment of the monoclonal antibody is labeled.
12. The method of claim 11, wherein the label is an enzyme, a radioisotope, a fluorescent compound, a colloidal metal, a chemiluminescent compound, a phosphorescent compound, or a bioluminescent compound.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A smart-home device, comprising:
a user interface including an electronic display having a first display mode and a second display mode, the first display mode generally requiring more power than said second display mode;
a processing system coupled to the user interface, the processing system being configured to be in operative communication with one or more environmental sensors for determining at least one environmental condition, and in operative communication with one or more input devices including said user interface; and
at least one sensor configured to detect a physical closeness of a user to the at least one sensor, the at least one sensor being in operative communication with the processing system, the processing system being configured to cause the electronic display to be in the first display mode when a closeness threshold has been exceeded;
wherein said processing system is further configured to automatically adjust said closeness threshold based at least in part on a historical plurality of physical closeness events as detected by the at least one sensor.
2. The smart-home device of claim 1, wherein said closeness threshold is automatically adjusted based on a tracked number of times that the electronic display was caused to be in the first display mode responsive to physical closeness events over a predetermined time interval, the closeness threshold being made more restrictive if said tracked number of times was greater than a predetermined activity threshold, whereby excessive entry of the electronic display into the first display mode responsive to sensed physical closeness events is reduced.
3. The smart-home device of claim 1, wherein said closeness threshold is automatically adjusted based at least in part on a joint processing of (i) the historical plurality of physical closeness events as detected by the at least one sensor, and (ii) a historical plurality of user interface manipulation events in which the user has actually manipulated said user interface, wherein the closeness threshold is made less restrictive if there is a higher correlation between said physical closeness events and said manipulation events, and wherein the closeness threshold is made more restrictive if there is a lesser correlation between said physical closeness events and said manipulation events.
4. The smart-home device of claim 1, wherein said at least one sensor comprises a first sensor and a second sensor, wherein the first sensor is configured to detect the physical closeness of the user to the user interface within a first distance, wherein the second sensor is configured to detect the physical closeness of the user to the user interface within a second distance, and wherein the first distance is greater than the second distance.
5. The smart-home device of claim 4, wherein the first sensor comprises a Passive Infrared sensor (PIR) and the second sensor comprises an active proximity sensor that is configured to emit electromagnetic radiation and to receive reflections of said electromagnetic radiation.
6. The smart-home device of claim 4, wherein the second sensor comprises a near-range PIR.
7. The smart-home device of claim 1 wherein the processing system comprises a first processor and a second processor, wherein the first processor is configured to detect when the closeness threshold has been exceeded and to cause said second processor to transition from a low-power mode in response to the closeness threshold being exceeded, wherein the second processor causes the electronic display to operate in the first display mode.
8. A method for optimizing the operation of a user interface of a smart-home device, the method comprising:
determining automatically, by a processing system, a closeness threshold based at least in part on a historical plurality of physical closeness events as detected by at least one sensor; the at least one sensor configured to detect a physical closeness of a user to the at least one sensor, the at least one sensor being in operative communication with the processing system
detecting a physical closeness of a user to the at least one sensor;
determining, by the processing system, that the closeness threshold has been exceeded, the processing system being configured to be in operative communication with one or more environmental sensors for determining at least one environmental condition, and in operative communication with one or more input devices including said user interface;
causing, by the processing system, an electronic display to be in a first display mode when the closeness threshold has been exceeded, the user interface including the electronic display having the first display mode and a second display mode, the first display mode generally requiring more power than said second display mode.
9. The method of claim 8, wherein said closeness threshold is automatically adjusted based on a tracked number of times that the electronic display was caused to be in the first display mode responsive to physical closeness events over a predetermined time interval, the closeness threshold being made more restrictive if said tracked number of times was greater than a predetermined activity threshold, whereby excessive entry of the electronic display into the first display mode responsive to sensed physical closeness events is reduced.
10. The method of claim 8, wherein said closeness threshold is automatically adjusted based at least in part on a joint processing of (i) the historical plurality of physical closeness events as detected by the at least one sensor, and (ii) a historical plurality of user interface manipulation events in which the user has actually manipulated said user interface, wherein the closeness threshold is made less restrictive if there is a higher correlation between said physical closeness events and said manipulation events, and wherein the closeness threshold is made more restrictive if there is a lesser correlation between said physical closeness events and said manipulation events.
11. The method of claim 8, wherein said at least one sensor comprises a first sensor and a second sensor, wherein the first sensor is configured to detect the physical closeness of the user to the user interface within a first distance, wherein the second sensor is configured to detect the physical closeness of the user to the user interface within a second distance, and wherein the first distance is greater than the second distance.
12. The method of claim 11, wherein the first sensor comprises a Passive Infrared sensor (PIR) and the second sensor comprises an active proximity sensor that is configured to emit electromagnetic radiation and to receive reflections of said electromagnetic radiation.
13. The method of claim 11, wherein the second sensor comprises a near-range PIR.
14. The method of claim 8 wherein the processing system comprises a first processor and a second processor, wherein the first processor is configured to detect when the closeness threshold has been exceeded and to cause said second processor to transition from a low-power mode in response to the closeness threshold being exceeded, wherein the second processor causes the electronic display to operate in the first display mode.
15. A smart-home device, comprising:
a user interface that is configured to operate in at least two different modes comprising:
a first mode, and
a second mode, wherein the user interface requires more power when operating in the first mode than in the second mode;
a plurality of sensors, including at least one sensor configured to detect a presence of a user within a proximity of the smart-home device; and
a first processing function that is configured to determine a proximity profile and to cause the user interface to be in the first mode when one or more of the plurality of sensors provides one or more responses to the first processing function that matches the proximity profile, wherein the proximity profile is determined using at least a history of responses from the plurality of sensors that are likely to coincide with times where one or more users intend to view the user interface.
16. The smart-home device of claim 15 further comprising a power stealing circuit configured to supply a first power level, wherein the user interface requires a second power level when operating in the first mode, and wherein the second power level is greater than the first power level.
17. The smart-home device of claim 15 wherein the proximity profile is adjusted based on a power level currently being supplied by a rechargeable battery, whereby the user interface is less likely to be caused to operate in the first mode in response to a physical closeness event.
18. The smart-home device of claim 15 wherein the at least one sensor comprises a first sensor and a second sensor, wherein the first sensor is configured to detect a presence of a user within a first proximity comprising first distance, wherein the second sensor is configured to detect a presence of a user within a second proximity comprising a second distance, and wherein the first distance is greater than the second distance.
19. The smart-home device of claim 15 wherein the processing function comprises a first processor and a second processor, wherein the first processor is configured to determine whether the one or more responses matches the proximity profile, and wherein the second processor is configured to cause the user interface to operate in the first mode.
20. The smart-home device of claim 15 wherein the processing function is further configured to detect when a number of physical closeness events within a predetermined time interval exceed a predetermined activity threshold and adjust the proximity profile in response.