1. A game for at least two players, comprising:
A rectangular game box with a top game surface having three uniformly formed circular holes each with a depth just slightly less than the length of a square game piece peg;
said game box having the first circular hole being disposed toward the bottom left side of the top game surface of said game box, the second circular hole being disposed toward the right side of said game surface, in line with the leftmost circular hole, and with an arrow painted on said game surface from the leftmost circular hole and continuing to the rightmost circular hole with the arrowhead terminating at the center edge of the rightmost circular hole, and with the third circular hole being disposed toward the edge of said game surface farthest away from and centered between said leftmost and rightmost circular holes with an arrow painted on said game surface from the rightmost circular hole and continuing to said farthest game surface edge circular hole with the arrowhead terminating at the downward right edge of said farthest edge circular hole;
a plurality of square game piece pegs with a uniform length and a dimension from one square point to the opposite square point that is slightly less than the diameter of said three circular holes on said game surface of said game box so as to fit inside a circular hole on said game surface of said game box; and
a plurality of square game piece pegs with a uniform length and a dimension from one square point to the opposite square point that is slightly larger than the diameter of said three circular holes on said game surface of said game box so as not to fit inside a circular hole on said game surface of said game box.
2. The game according to claim 1 wherein said game box is hollow.
3. The game according to claim 1 wherein said game box is solid.
4. The game according to claim 1 wherein said circular holes on said game surface are of the same diameter.
5. The game according to claim 1 wherein said circular holes on said game surface are of different diameters.
6. The game according to claim 1 wherein said arrows are inscribed on said game surface.
7. The game according to claim 1 wherein said arrows are pre-printed on said game surface.
8. A method of playing a game by at least two players on the top game surface of a rectangular game box having three formed circular holes in said game surface, one disposed toward the left side of said game surface, one disposed toward the right side of said game surface, having an arrow between the leftmost and rightmost circular holes with the arrowhead terminating on the leftmost edge of the rightmost circular hole, and a third circular hole disposed toward the farthest edge and centered between the closer two holes and having an arrow on said game surface from the rightmost circular hole to the farthest centered circular hole, with the arrowhead on said arrow terminating at the right downward side of the farthest centered circular hole, a plurality of square game piece pegs with a uniform length and a dimension from one square point to the opposite square point that is slightly less than the diameter of said three circular holes on said game surface of said game box so as to fit inside a circular hole on said game surface of said game box, and a plurality of square game piece pegs with a uniform length and a dimension from one square point to the opposite square point that is slightly larger than the diameter of said three circular holes on said game surface of said game box so as not to fit inside a circular hole on said game surface of said game box, comprising:
(a) All square game pegs are placed in a central location and thoroughly mixed;
(b) Each game player having a rectangular game box with a game surface;
(c) In the first turn of the game all players take four game pegs from the central location, play begins with selections from these first four game pegs, and when exhausted, continues with single selections from the central location;
(d) One player begins a round by randomly selecting a square game peg and attempting to fit it into the first available circular opening, starting from left to right then to the farthest centered circular hole;
(e) If the player’s game peg does not fit, the turn continues to the next player, counter-clockwise from the present player;
(f) If the player’s game peg fits into a circular hole, the leftmost hole counts as 500 points, the rightmost hole counts as 1,000 points and the farthest, centered hole counts as 1,500 points;
(g) The turns continue until one player fills all three holes on their own game surface, this concludes a round, and the player first filling all three holes gets the total of 3,000 points plus the unused peg points for that round accumulated by all the other players;
(h) Play continues with step (a) above, until one player meets or exceeds 6,000 points, at which event, the game concludes.
9. The method of claim 8, wherein there are 10 square game pegs that fit said circular holes on said game surface and there are 50 square game pegs that do not fit said circular holes on said game surface.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound of formula (I)
wherein
A denotes
X, Y and Z, independently of one another, denote hydrogen, C1-C4-alkyl or C2-C4-alkenyl,
wherein two of the radicals X, Y and Z are optionally covalently bonded to one another under formation of a bicyclic ring system,
B denotes NR1R2, wherein
R1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms,
R2 denotes an organic radical having 1 to 14 carbon atoms,
and
wherein R1 and R2 are optionally covalently bonded to one another,
or a cosmetically or pharmaceutically acceptable salt thereof.
2. (canceled)
3. The compound according to claim 1, wherein R1 denotes hydrogen andor wherein A denotes
4. The compound according to claim 1, wherein R2 denotes an organic radical having 1 to 12 carbon atoms.
5. The compound according to claim 1, wherein A denotes
and
wherein X and Y, independently of one another, denote C1-C4-alkyl or C2-C4-alkenyl.
6. The compound according to claim 5, wherein X and Y, independently of one another, denote methyl, iso-propyl or tert.-butyl.
7. The compound according to claim 1, wherein A denotes
and
wherein X denotes C1-C4-alkyl or C2-C4-alkenyl.
8. The compound according to claim 1, wherein A denotes
and wherein X, Y and Z, independently of one another, denote C1-C4-alkyl or C2-C4-alkenyl.
9. A cosmetic or pharmaceutical composition comprising:
(a) a compound of formula (I) according to claim 1 andor a cosmetically or pharmaceutically acceptable salt thereof;
and
(b) a further anti-ageing active suitable for cosmetic or pharmaceutical application, wherein the anti-ageing active is not a compound of formula (I);
and
(c) optionally comprises a cosmetically or pharmaceutically acceptable carrier.
10. The composition according to claim 9, wherein the further anti-ageing active of component (b) is selected from the group consisting of:
antioxidants,
substances which absorb or reflect UV radiation,
skin moisturizing agents,
further SIRT1 activators,
further proteasome activators,
glycosaminoglycans and substances stimulating the synthesis of glycosaminoglycans,
matrix-metalloproteinase (MMP) inhibitors,
and
substances stimulating the formation of collagen.
11. The composition according to claim 9, wherein
a total quantity of compounds of formula (I) is in a range of from 0.001 to 30 wt. %.
12. The composition according to claim 9, wherein
a total quantity of antioxidants is in a range of from 0.001 to 10 wt. %,
andor
a total quantity of UV filter substances (UV absorbers) is in a range of from 0.01% to 40% by weight,
andor
a total quantity of skin moisturizing agents is in a range of from 0.1 to 30 wt. %,
andor
a total quantity of SIRT1 activators is in a range of from 0.001 to 15 wt. %,
andor
a total quantity of further proteasome activators is in a range of from 0.01 to 15 wt. %,
andor
a total quantity of glycosaminoglycans and substances stimulating the synthesis of glycosaminoglycans is in a range of from 0.01 to 10 wt. %,
andor
a total quantity of matrix-metalloproteinase (MMP) inhibitors is in a range of from 0.01 to 5 wt. %,
andor
a total quantity of substances stimulating the formation of collagen is in a range of from 0.01 to 5 wt. %,
in each case based on the total weight of the composition.
13. The composition according to claim 9, wherein the further anti-ageing active of component (b) is selected from the group consisting of:
(b-1) vitamin A, tocopherol, tocopheryl acetate, vitamin C or ubiquinone;
(b-2) organic UV absorbers from the class of 4-aminobenzoic acid or 4-aminobenzoic acid derivatives, salicylic acid derivatives, benzophenone derivatives, dibenzoylmethane derivatives, diphenyl acrylates, 3-imidazol-4-yl acrylic acid or esters thereof, benzofuran derivatives, benzylidene malonate derivatives, polymeric UV absorbers containing one or more organosilicon radicals, cinnamic acid derivatives, camphor derivatives, trianilino-s-triazine derivatives, 2-hydroxyphenylbenzotriazole derivatives, phenylbenzimidazole sulfonic acid derivatives or salts thereof, anthranilic acid menthyl esters, benzotriazole derivatives, or indole derivatives;
(b-3) C3-C10-alkane diols or C3-C10-alkane triols;
(b-4) hydroxyresveratrol, resveratrol, Myrtus communis leaf extract, or palmitoyl tetrapeptide-10;
(b-5) oleuropein, Phaeodactylum tricornutum extract, or palmitoyl isoleucin;
(b-6) hyaluronic acid, retinol, retinyl palmitate, Alpinia galanga leaf extract, or tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate;
(b-7) retinyl palmitate, ursolic acid, genistein, or daidzein; and
(b-8) carnitine, carnosine or magnesium ascorbyl phosphate.
14. A compound selected from the group consisting of:
or a cosmetically or pharmaceutically acceptable salt thereof.
15. A method for any one of the following:
proteasomal clearance in a cell andor
stimulation of activity andor expression of one or more sirtuin proteins (sirtuins), andor
prevention, treatment or reduction of a cosmetic skin ageing effect, andor inflammation-induced ageing, andor
regulation of the skin tone, andor
prevention, treatment or reduction of oxidative stress, andor
inhibition of UV-induced erythema,
comprising:
applying a cosmetically effective amount of a compound of formula (I), or a cosmetically acceptable salt of a compound of formula (I), or a mixture containing two or more compounds of formula (I), or the salts thereof, as defined in claim 1 to human skin.
16. (canceled)
17. A pharmaceutical composition comprising a pharmaceutically active amount of a compound of formula (I) according to claim 1.
18. A method for treating a disease
comprising:
topically applying a pharmaceutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt of a compound of formula (I), or a mixture comprising two or more compounds of formula (I), or the salts thereof, according to claim 1.
19. The compound according to claim 4, wherein R2 denotes an organic radical having 1 to 8 carbon atoms.
20. The compound according to claim 5, wherein X and Y, independently of one another, denote C1-C4alkyl.
21. The compound according to claim 6, wherein A denotes:
22. The method according to claim 18, wherein the disease is selected from the group consisting of: an age-associated disease, a skin ageing effect, and insulin sensitivity.