Author: claimsbot

1. A method for the quantitative determination of an impurity present in a peptide product composition, comprising the steps:
(a) providing a peptide product composition comprising a peptide product and an unknown amount of at least one impurity, wherein said impurity cannot be separated from the peptide product or another ingredient of the composition by a chromatographic procedure,
(b) providing at least one sample of the peptide product composition without said impurity added and optionally at least one further sample of the peptide product composition with a known amount of said impurity added,
(c) quantitatively determining said impurity in said sample from step (b) by mass spectrometry, and
(d) calculating the amount of said impurity in the peptide product composition based on the results of (c).
2. The method according to claim 1 wherein step (b) comprises providing at least three samples of the peptide product composition, wherein a first sample comprises the peptide product composition without said impurity added, and wherein at least two further samples comprise the peptide product composition each with a different known amount of said impurity added.
3. The method of claim 1, wherein the peptide product has a length of from 5-100 amino acids.
4. The method of claim 1, wherein the peptide product has been chemically synthesized, particularly by a solid phase synthesis procedure, or produced by recombinant DNA processes.
5. The method of claim 1, wherein the peptide product composition is a pharmaceutical formulation or a composition intended for the manufacture of a pharmaceutical formulation.
6. The method of claim 1, wherein the peptide product is an exendin peptide, particularly Lixisenatide (AVE0010).
7. The method of claim 1, wherein the impurity is a peptide impurity.
8. The method of claim 1, wherein the impurity cannot be quantitatively separated from the peptide product or from another ingredient of the composition by an HPLC procedure, particularly by a Reverse Phase HPLC procedure.
9. The method of claim 1, wherein the peptide product comprises unknown amounts of at least 2 impurities which cannot be quantitatively separated from the peptide product or from another ingredient of the composition by a chromatographic procedure.
10. The method of claim 1, wherein the impurity is added to at least one peptide product composition sample from a stock preparation, preferably from at least two stock preparations comprising different concentrations of the impurity.
11. The method of claim 1, wherein at least 3 or 4 further samples with different known amounts added impurity are provided and subjected to mass spectrometry determination.
12. The method of claim 1, wherein the mass spectrometry is high resolution mass spectrometry.
13. The method of claim 1, wherein the calculation comprises a linear regression analysis.
14. The method of claim 13, wherein the calculation is carried out according to the equation:
y=ax+b

wherein a=slope
y=determined peak area of the impurity in a sample
x=added amount of the impurity in a sample
b=intercept

and the unknown amount of the impurity xt is obtained as follows:
xt=b\xb7a\u22121
15. The method of claim 12, wherein said high resolution mass spectrometry comprises Fourier Transform mass spectrometry.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A solid-state imaging device including a lamination-type backside illumination CMOS (Complementary Metal Oxide Semiconductor) image sensor having a global shutter function, the solid-state imaging device comprising
a separation film including one of a light blocking film and a light absorbing film between a memory and a photo diode.
2. The solid-state imaging device according to claim 1, further comprising a vertical transistor configured to transfer charge from the photo diode to the memory.
3. The solid-state imaging device according to claim 2, further comprising a floating diffusion, wherein
the vertical transistor is disposed at an end of the photo diode such that a pitch of the photo diode coincides with a pitch of the vertical transistor, the memory, and the floating diffusion.
4. The solid-state imaging device according to claim 2, further comprising a floating diffusion, wherein
the vertical transistor is disposed at the center of the photo diode such that a pitch of the photo diode coincides with a pitch of the vertical transistor, the memory, and the floating diffusion.
5. The solid-state imaging device according to claim 1, further comprising a floating diffusion, wherein
the photo diode, the memory, and the floating diffusion are provided on respective layers and laminated on one another, to form a three-layer structure.
6. The solid-state imaging device according to claim 1, wherein
the separation film including the light blocking film is formed of metal.
7. The solid-state imaging device according to claim 6, wherein
a negative potential is applied to the separation film including the light blocking film and being formed of metal.
8. The solid-state imaging device according to claim 6, wherein
the separation film including the light blocking film and being formed of metal is connected to an outside of a pixel array.
9. The solid-state imaging device according to claim 1, wherein
the separation film including the light absorbing film includes a film formed of a compound semiconductor having a chalcopyrite structure.
10. An electronic apparatus including a solid-state imaging device including a lamination-type backside illumination CMOS (Complementary Metal Oxide Semiconductor) image sensor having a global shutter function, the electronic apparatus comprising
a separation film including one of a light blocking film and a light absorbing film between a memory and a photo diode.
11. A method of manufacturing a solid-state imaging device including a lamination-type backside illumination CMOS (Complementary Metal Oxide Semiconductor) image sensor having a global shutter function, the solid-state imaging device including a separation film including one of a light blocking film and a light absorbing film between a memory and a photo diode, the method comprising:
a first step of forming an insulating film on one surface of a first substrate on which the memory is formed and an insulating film on one surface of a second substrate on which the photo diode is formed, and forming the separation film on the insulating film of the first substrate and the separation film on the insulating film of the second substrate;
a second step of bonding the first substrate and the second substrate to each other, with the surface of the first substrate on which the separation film is formed and the surface of the second substrate on which the separation film is formed facing each other, to form an integrated substrate; and
a third step of thinning the integrated substrate.
12. The method of manufacturing a solid-state imaging device according to claim 11, wherein
the first step includes forming an SCF (Si cover film) on each of the one surface of the first substrate and the one surface of the second substrate before the insulating films are formed.
13. The method of manufacturing a solid-state imaging device according to claim 12, further comprising
a fourth step of forming the photo diode on a surface that is different from the surface of the second substrate on which the insulating film is formed, after the insulating films and the separation films are formed in the first step and before the second step is performed.
14. The method of manufacturing a solid-state imaging device according to claim 12, further comprising
a fourth step of forming the photo diode on a surface that is different from the surface of the second substrate on which the insulating film is formed, after the third step is performed.
15. A solid-state imaging device manufactured by a method of manufacturing a solid-state imaging device including a lamination-type backside illumination CMOS (Complementary Metal Oxide Semiconductor) image sensor having a global shutter function, the solid-state imaging device including a separation film including one of a light blocking film and a light absorbing film between a memory and a photo diode, the method comprising:
a first step of forming an insulating film on one surface of a first substrate on which the memory is formed and an insulating film on one surface of a second substrate on which the photo diode is formed, and forming the separation film on the insulating film of the first substrate and the separation film on the insulating film of the second substrate;
a second step of bonding the first substrate and the second substrate to each other, with the surface of the first substrate on which the separation film is formed and the surface of the second substrate on which the separation film is formed facing each other, to form an integrated substrate; and
a third step of thinning the integrated substrate.

1. A head covering comprising a skull portion having a dome shape, a rim, and a visor having an edge facing said rim and expandable means interposed between said rim of said skull portion and said edge of said visor, said expandable means comprising material foldable along a fold line to define first and second portions, the first portion being attached to and extending from said edge of said visor and the second portion extending from said rim of said skull portion, such that said first and second portions are in substantially face-to-face relation and said edge of said visor is substantially adjacent said rim of said skull portion when said material is folded, wherein said expandable means is moveable between an expanded position and a retracted position to move said visor between a position proximate said skull portion and a position remote from said skull portion, and means for securing said expandable means in said retracted position, wherein said expandable means is situated entirely within said skull portion in said retracted position.
2. The covering of claim 1 wherein said securing means comprises inter-engaging hook and loop ribbon segments.
3. The covering of claim 1 in the form of a baseball cap.
4. A head covering comprising a skull portion having a dome shape, a rim, and a visor having an edge facing said rim, expandable means interposed between said rim of said skull portion and said edge of said visor, said expandable means comprising material foldable along a fold line to form first and second portions, the first portion being attached to and extending from said edge of said visor and the second portion extending from said rim of said skull portion, such that said first and second portions are in substantially face-to-face relation and said edge of said visor is substantially adjacent said rim of said skull portion when said material is folded, wherein said expandable means is moveable between an expanded position and a retracted position to move said visor between a position proximate to said skull portion and a position remote from said skull portion, means for securing said expandable means in said retracted position and a protective helmet, wherein said expandable means is situated entirely within said skull portion in said retracted position.
5. The covering of claim 4 wherein said skull portion is placed on the head with the visor facing backward, the expandable means is expanded such that the visor is aligned with at least a portion of the neck of the wearer and the helmet is situated over the skull portion.
6. The covering of claim 4 in the form of a baseball cap.
7. The covering of claim 4 wherein said securing means comprises inter-engaging hook and loop ribbon segments.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A lamp comprising:
a lamp capsule having a sealed end and a central longitudinal axis;
a base formed from an electrically insulating material, having an end of the base with a wall defining a receptacle sized and shaped to receive, along an axis of the base, the sealed end of the lamp capsule;
a first flange extending from a first side of the base, and transverse to the axis; the first flange having a first electrical contact exposed for electrical contact, the first electrical contact comprising on an upper surface thereof an upwardly facing first upper exposed contact region and on a lower surface thereof a downwardly facing first lower exposed contact region that is, in an axial direction, in register with the first upper exposed contact region and facing away from the first upper exposed contact region;
a second flange extending from a second side of the base opposite the first side of the base, and extending transverse to the axis; the second flange having a second electrical contact exposed for electrical contact, the second electrical contact comprising on an upper surface thereof an upwardly facing second upper exposed contact region and on a lower surface thereof a downwardly facing second lower exposed contact region that is, in an axial direction, in register with the second upper exposed contact region and facing away from the second upper exposed contact region; and
the lamp capsule being irremovably held in the receptacle and being electrically coupled via respective lead wires to the first electrical contact and the second electrical contact, each of the first and second contacts being wider, in a direction extending radially away from the lamp central longitudinal axis, than a lateral width of the respective said lead wire.
2. The lamp in claim 1, wherein the first flange and the second flange are similarly formed.
3. The lamp in claim 1, wherein the first electrical contact and the second electrical contact are similarly formed.
4. The lamp in claim 1, wherein the lamp is a press sealed lamp, and the press seal is held in the base.
5. The lamp in claim 1, wherein the first flange includes a top side, and the electrical contact is further exposed for electrical contact on the top side of the flange.
6. The lamp in claim 1, wherein the first flange includes a bottom side, and the first electrical contact is further exposed for electrical contact on the bottom side of the flange.
7. The lamp in claim 1, wherein at least one of the first flange and the second flange has a radial side, the radial side including a portion of a body of rotation about the axis.
8. A lamp comprising:
a lamp capsule having a press sealed end and a central longitudinal axis;
a base formed from an electrically insulating material, having an end of the base with a wall defining a receptacle sized and shaped to receive, along an axis of the base, the press sealed end of the lamp capsule;
a first flange extending from a first side of the base, and transverse to the axis; the first flange having a first electrical contact exposed for electrical contact, the first electrical contact comprising on an upper surface thereof an upwardly facing first upper exposed contact region and on a lower surface thereof a downwardly facing first lower exposed contact region that is, in an axial direction, in register with the first upper exposed contact region and facing away from the first upper exposed contact region;
a second flange, similarly formed to the first flange, extending from a second side of the base opposite the first side of the base, and extending transverse to the axis; the second flange having a second electrical contact, similarly formed to the first electrical contact, exposed for electrical contact, the second electrical contact comprising on an upper surface thereof an upwardly facing second upper exposed contact region and on a lower surface thereof a downwardly facing second lower exposed contact region that is, in an axial direction, in register with the second upper exposed contact region and facing away from the second upper exposed contact region; and
the lamp capsule being irremovably held along the press seal in the receptacle and being electrically coupled via respective lead wires to the first electrical contact and the second electrical contact,
the lamp capsule being irremovably held in the receptacle and being electrically coupled via respective lead wires to the first electrical contact and the second electrical contact, each of the first and second contacts being wider, in a direction extending radially away from the lamp central longitudinal axis, than a lateral width of the respective said lead wire.
9. The lamp in claim 1, wherein the first and second electrical contacts are formed separate from and disposed on the respective first and second flanges.
10. The lamp in claim 1, wherein the upwardly facing first and second upper exposed contact regions generally face in a direction of the lamp capsule, and the downwardly facing first and second lower exposed contact regions generally face in a direction away from the lamp capsule.
11. The lamp in claim 1, wherein the downwardly facing first and second lower exposed contact regions are unobstructed by the base.
12. The lamp in claim 11, wherein the upwardly facing first and second upper exposed contact regions are unobstructed by the base.
13. The lamp in claim 1, wherein the first and second flanges are diametrally opposite.
14. The lamp in claim 8, wherein the upwardly facing first and second upper exposed contact regions generally face in a direction of the lamp capsule, and the downwardly facing first and second lower exposed contact regions generally face in a direction away from the lamp capsule, and
wherein the downwardly facing first and second lower exposed contact regions are unobstructed by the base.
15. A lamp comprising:
a lamp capsule having a sealed end and a central longitudinal axis;
a base formed from an electrically insulating material, the base having a wall defining a receptacle sized and shaped to receive, along an axis of the base, the sealed end of the lamp capsule;
a first electrical contact extending transverse to the axis, the first electrical contact comprising an upwardly facing first upper exposed contact region and a downwardly facing first lower exposed contact region that is, in an axial direction, in register with the first upper exposed contact region and facing away from the first upper exposed contact region;
a second electrical contact extending transverse to the axis, the second electrical contact comprising an upwardly facing second upper exposed contact region and a downwardly facing second lower exposed contact region that is, in an axial direction, in register with the second upper exposed contact region and facing away from the second upper exposed contact region; and
the lamp capsule being irremovably held in the receptacle and being electrically coupled via respective lead wires to the first electrical contact and the second electrical contact, each of the first and second contacts being wider, in a direction extending radially away from the lamp central longitudinal axis, than a lateral width of the respective said lead wire.
16. The lamp in claim 15, wherein a potion of the electrically insulating base material is disposed, in an axial direction, between respective pairs of upper and lower exposed lower exposed contact regions.
17. The lamp in claim 15, wherein first and second flanges are formed on the base of the electrically insulating material, the first and second flanges being located spaced apart around the axis, the first and second electrical contacts being disposed on the respective first and second flanges.
18. The lamp in claim 15, wherein the upwardly facing first and second upper exposed contact regions generally face in a direction of the lamp capsule, and the downwardly facing first and second lower exposed contact regions generally face in a direction away from the lamp capsule.
19. The lamp in claim 16, wherein the downwardly facing first and second lower exposed contact regions are unobstructed by the base.
20. The lamp in claim 19, wherein the upwardly facing first and second upper exposed contact regions are unobstructed by the base.
21. The lamp in claim 1, wherein, at locations most radially distant from the lamp capsule, the first and second electrical contacts along both the upper and lower contact regions extend, in the axial direction, beyond adjacent portions of the lamp.
22. The lamp in claim 8, wherein, at locations most radially distant from the lamp capsule, the first and second electrical contacts along both the upper and lower contact regions extend, in the axial direction, beyond adjacent portions of the lamp.
23. The lamp in claim 15, wherein, at locations most radially distant from the lamp capsule, the first and second electrical contacts along both the upper and lower contact regions extend, in the axial direction, beyond adjacent portions of the lamp.