All The Claims

What is claimed is:

1. A method for identifying and measuring geometric, spatial, and anatomical changes in real-time in airway structures in a mammal during inhalation comprising the steps of:
using a magnetic resonance imaging device (MRI) to produce real-time dynamic images from said magnetic resonance imaging at a rapid rate thereby depicting the mobility of the airway structures during inhalation;
applying geometric alignment, spatial configuration, and volumetric descriptors to the different type of images produced with said magnetic resonance imaging;
evaluating such imaging to determine the anatomical changes in the airway structures during inhalation; and
wherein inhalation takes place through a mouthpiece used to dispense a substance which comprises an aerosol medicament, placebo or air.
2. The method of claim 1 wherein said substance includes a contrasting agent.
3. The method of claim 2 wherein the contrasting agent is gadolinium.
4. The method of claim 2 wherein the contrasting agent is technetium.
5. The method of claim 1 which further includes the step of magnetic resonance imaging the upper regions of the oropharyngeal, lower trachea and lungs of the mammal to determine flow of the substance within the airway structures.
6. The method of claim 1, further including the step of determining the flow rate during inhalation and correlating the flow rate data with the real-time imaging.
7. The method of claim 5, further including the step of determining flow rate data of inhalation and correlating the flow rate data with the real-time imaging.
8. The method of claim 6, wherein the flow rate data is determined simultaneously with the production of said real-time images.
9. The method of claim 7, wherein the flow rate data is determined simultaneously with the production of said real-time images.
10. The method of claim 6, further including the step of using said imaging and said flow rate data in determining design criteria for aerosol delivery devices.
11. The method of claim 7, further including the step of using said imaging and said flow rate data in determining design criteria for aerosol delivery devices.
12. The method of claim 6, further including the step of using said imaging and said flow rate data to establish a database of information for a plurality of delivery devices.
13. The method of claim 7, further including the step of using said imaging and said flow rate data to establish a database of information for a plurality of delivery devices.
14. The method of claim 4, further including the step of determining an amount and location of the substance being dispensed into the airway.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

I claim:

1. A method of producing a security document, comprising:
providing multi-bit binary data;
forming a pattern of recesses in a metal member, said pattern having the multi-bit binary data encoded therein; and
pressing a substrate into said metal member to texture the substrate in accordance with said binary data.
2. The method of claim 1 further including inking the recesses prior to the pressing.
3. The method of claim 1 in which the pattern has the multi-bit binary data steganographically encoded therein, wherein a human viewer of the texture on the substrate is not alerted that it conveys multi-bit binary data.

1. A closure assembly comprising:
a transfer tubing defining a fluid passageway, the tubing having an end surface; and
a membrane material disposed across the fluid passageway to provide a fluid tight seal, the membrane material being a multiple layered polymeric structure.
2. The closure of claim 1 wherein the membrane material is attached to the end surface of the tubing.
3. The closure of claim 1 wherein the membrane comprises:
a first layer of an ethylene vinyl alcohol copolymer having first side and a second side; and
a second layer of a modified ethylene vinyl acetate copolymer attached to the first side of the first layer.
4. The closure of claim 3 wherein the second layer is positioned between the first layer of ethylene vinyl alcohol copolymer and the end of the tubing.
5. The closure of claim 3 wherein the ethylene vinyl alcohol copolymer has an ethylene content of from about 25% to about 45% by mole percent.
6. The closure of claim 3 wherein the ethylene vinyl alcohol copolymer has an ethylene content of from about 28% to about 36% by mole percent.
7. The closure of claim 3 wherein the ethylene vinyl alcohol copolymer has an ethylene content of from about 30% to about 34% by mole percent.
8. The closure of claim 3 wherein the modified ethylene vinyl acetate copolymer has a modifying group selected from the group consisting of: carboxylic acid and carboxylic acid anhydrides.
9. The closure of claim 8 wherein the modifying group is maleic acid, fumaric acid, itaconic acid, citraconic acid, allylsuccinic acid, cyclohex-4-ene-1,2-dicarboxylic acid, 4-methylcyclohex-4-ene-1,2-dicarboxylic acid, bicyclo2.2.1hept-5-ene-2,3-dicarboxylic acid, x-methylbicyclo2.2.1hept-5-ene-2,3-dicarboxylic acid, maleic anhydride, itaconic anhydride, citraconic anhydride, allylsuccinic anhydride, cyclohex-4-ene-1,2-dicarboxylic anhydride, 4-methylcyclohex-4-ene-1,2-dicarboxylic anhydride, bicyclo{2.2.1}hept-5-ene2,3-dicarboxylic anhydride, x-methylbicyclo2.2.1hept-5-ene-2,2-dicarboxylic anhydride, methyl acrylate, methyl methacrylate, ethyl acrylate, ethyl methacrylate, butyl acrylate, butyl methacrylate, glycidyl acrylate, glycidal methacrylate, monoethyl maleate, diethyl maleate, monomethyl maleate, diethyl maleate, monomethyl fumarate, dimethyl fumarate, monomethyl itaconate, diethylitaconate, amide derivatives of unsaturated carboxylic acids including acrylamide, methacrylamide, maleicmonoamide, maleic diamide, maleic N-monoethylamide, maleic N,N-diethylamide, maleic N-monobutylamide, maleic N,N dibutylamide, fumaric monoamide, fumaric diamide, fumaric N-monoethylamide, fumaric N,N-diethylamide, fumaric N-monobutylamide and fumaric N,N-dibutylamide, imide derivatives of unsaturated carboxylic acids including maleimide, N-butylmaleimide and N-phenylmaleimide; and metal salts of unsaturated carboxylic acids including sodium acrylate, sodium methacrylate, potassium acrylate or potassium methacrylate.
10. The closure of claim 9 wherein the modifying group is a fused ring carboxylic acid anhydride.
11. The closure of claim 1 further comprising a third layer attached to the second side of the first layer.
12. The closure of claim 11 wherein the third layer is selected from the group consisting of polyamides and polyesters.
13. The closure of claim 12 wherein the polyamides are aliphatic polyamides obtained from the condensation reaction of di-amines having a carbon number within a range of 2-13, aliphatic polyamides resulting from a condensation reaction of di-acids having a carbon number within a range of 2-13, polyamides resulting from the condensation reaction of dimer fatty acids, and amide containing copolymers.
14. The closure of claim 12 wherein the polyamide is obtained from a ring-opening reaction of a lactam having from 4-12 carbons.
15. The closure of claim 12 wherein the modified ethylene vinyl acetate copolymer has a modifying group selected from the group consisting of: carboxylic acid and carboxylic acid anhydrides.
16. The closure of claim 15 wherein the modifying group is maleic acid, fumaric acid, itaconic acid, citraconic acid, allylsuccinic acid, cyclohex-4-ene-1,2-dicarboxylic acid, 4-methylcyclohex-4-ene-1,2-dicarboxylic acid, bicyclo2.2.1hept-5-ene-2,3-dicarboxylic acid, x-methylbicyclo2.2.1hept-5-ene-2,3-dicarboxylic acid, maleic anhydride, itaconic anhydride, citraconic anhydride, allylsuccinic anhydride, cyclohex-4-ene-1,2-dicarboxylic anhydride, 4-methylcyclohex-4-ene-1,2-dicarboxylic anhydride, bicyclo{2.2.1}hept-5-ene2,3-dicarboxylic anhydride, x-methylbicyclo2.2.1hept-5-ene-2,2-dicarboxylic anhydride, methyl acrylate, methyl methacrylate, ethyl acrylate, ethyl methacrylate, butyl acrylate, butyl methacrylate, glycidyl acrylate, glycidal methacrylate, monoethyl maleate, diethyl maleate, monomethyl maleate, diethyl maleate, monomethyl fumarate, dimethyl fumarate, monomethyl itaconate, diethylitaconate, amide derivatives of unsaturated carboxylic acids including acrylamide, methacrylamide, maleicmonoamide, maleic diamide, maleic N-monoethylamide, maleic N,N-diethylamide, maleic N-monobutylamide, maleic N,N dibutylamide, fumaric monoamide, fumaric diamide, fumaric N-monoethylamide, fumaric N,N-diethylamide, fumaric N-monobutylamide and fumaric N,N-dibutylamide, imide derivatives of unsaturated carboxylic acids including maleimide, N-butylmaleimide and N-phenylmaleimide; and metal salts of unsaturated carboxylic acids including sodium acrylate, sodium methacrylate, potassium acrylate or potassium methacrylate.
17. The closure of claim 16 wherein the modifying group is a fused ring carboxylic acid anhydride.
18. The closure of claim 11 wherein the ethylene vinyl alcohol copolymer has an ethylene content of from about 25% to about 45% by mole percent.
19. The closure of claim 11 wherein the ethylene vinyl alcohol copolymer has an ethylene content of from about 28% to about 36% by mole percent.
20. The closure of claim 18 wherein the ethylene vinyl alcohol copolymer has an ethylene content of from about 30% to about 34% by mole percent.
21. A closure assembly comprising:
a transfer tubing having a multiple layered structure defining a fluid passageway, the tubing having an end surface; and
a membrane material disposed across the fluid passageway to provide a fluid tight seal.
22. The closure of claim 21 wherein the membrane material is attached to the end surface of the tubing.
23. The closure of claim 21 wherein the tubing is a multiple layered tubing.
24. The closure of claim 23 wherein the tubing has a layer of a barrier material.
25. The closure of claim 24 wherein the barrier material is a barrier to the transmission of oxygen.
26. The closure of claim 23 wherein the tubing has a first layer and a second layer, the first layer comprising an ethylene vinyl alcohol copolymer; and a second layer connected to the first layer and comprising a polyolefin, the first layer and the second layer being coaxially disposed with respect to one another.
27. The closure of claim 26 wherein the first layer is disposed coaxially within the second layer.
28. The closure of claim 26 wherein the first layer is disposed coaxially about the second layer.
29. The closure of claim 26 wherein the polyolefin is selected from the group consisting of: (1) ethylene and \u03b1-olefin interpolymers having a density of less than about 0.915 gcc, (2) ethylene vinyl acetate copolymers, and (3) modified ethylene vinyl acetate copolymers.
30. The closure of claim 29 wherein the polyolefin is an ethylene and \u03b1-olefin copolymer.
31. The closure of claim 29 wherein the polyolefin is an ethylene vinyl acetate copolymer.
32. The closure of claim 29 wherein the polyolefin is a modified ethylene vinyl acetate copolymer.
33. The closure of claim 32 wherein the modified ethylene vinyl acetate copolymer has a modifying group selected from the group consisting of: carboxylic acid and carboxylic acid anhydrides.
34. The closure of claim 33 wherein the modifying group is maleic acid, fumaric acid, itaconic acid, citraconic acid, allylsuccinic acid, cyclohex-4-ene-1,2-dicarboxylic acid, 4-methylcyclohex-4-ene-1,2-dicarboxylic acid, bicyclo2.2.1hept-5-ene-2,3-dicarboxylic acid, x-methylbicyclo2.2.1hept-5-ene-2,3-dicarboxylic acid, maleic anhydride, itaconic anhydride, citraconic anhydride, allylsuccinic anhydride, cyclohex-4-ene-1,2-dicarboxylic anhydride, 4-methylcyclohex-4-ene-1,2-dicarboxylic anhydride, bicyclo{2.2.1}hept-5-ene2,3-dicarboxylic anhydride, x-methylbicyclo2.2.1hept-5-ene-2,2-dicarboxylic anhydride, methyl acrylate, methyl methacrylate, ethyl acrylate, ethyl methacrylate, butyl acrylate, butyl methacrylate, glycidyl acrylate, glycidal methacrylate, monoethyl maleate, diethyl maleate, monomethyl maleate, diethyl maleate, monomethyl fumarate, dimethyl fumarate, monomethyl itaconate, diethylitaconate, amide derivatives of unsaturated carboxylic acids including acrylamide, methacrylamide, maleicmonoamide, maleic diamide, maleic N-monoethylamide, maleic N,N-diethylamide, maleic N-monobutylamide, maleic N,N dibutylamide, fumaric monoamide, fumaric diamide, fumaric N-monoethylamide, fumaric N,N-diethylamide, fumaric N-monobutylamide and fumaric N,N-dibutylamide, imide derivatives of unsaturated carboxylic acids including maleimide, N-butylmaleimide and N-phenylmaleimide; and metal salts of unsaturated carboxylic acids including sodium acrylate, sodium methacrylate, potassium acrylate or potassium methacrylate.
35. The closure of claim 34 wherein the modifying group is a fused ring carboxylic acid anhydride.
36. The closure of claim 26 further comprising a third layer of a polyolefin.
37. The closure of claim 36 wherein the third layer is of the same material as the second layer.
38. The closure of claim 36 wherein the third layer is of a different material from the second layer.
39. The closure of claim 36 wherein the polyolefin is an ethylene and \u03b1-olefin copolymer.
40. The closure of claim 36 wherein the polyolefin is an ethylene vinyl acetate copolymer.
41. The closure of claim 36 wherein the polyolefin is a modified ethylene vinyl acetate copolymer.
42. The closure of claim 41 wherein the modified ethylene vinyl acetate copolymer has a modifying group selected from the group consisting of: carboxylic acid and carboxylic acid anhydrides.
43. The closure of claim 42 wherein the modifying group is maleic acid, fumaric acid, itaconic acid, citraconic acid, allylsuccinic acid, cyclohex-4-ene-1,2-dicarboxylic acid, 4-methylcyclohex-4-ene-1,2-dicarboxylic acid, bicyclo2.2.1hept-5-ene-2,3-dicarboxylic acid, x-methylbicyclo2.2.1hept-5-ene-2,3-dicarboxylic acid, maleic anhydride, itaconic anhydride, citraconic anhydride, allylsuccinic anhydride, cyclohex-4-ene-1,2-dicarboxylic anhydride, 4-methylcyclohex-4-ene-1,2-dicarboxylic anhydride, bicyclo{2.2.1}hept-5-ene2,3-dicarboxylic anhydride, x-methylbicyclo2.2.1hept-5-ene-2,2-dicarboxylic anhydride, methyl acrylate, methyl methacrylate, ethyl acrylate, ethyl methacrylate, butyl acrylate, butyl methacrylate, glycidyl acrylate, glycidal methacrylate, monoethyl maleate, diethyl maleate, monomethyl maleate, diethyl maleate, monomethyl fumarate, dimethyl fumarate, monomethyl itaconate, diethylitaconate, amide derivatives of unsaturated carboxylic acids including acrylamide, methacrylamide, maleicmonoamide, maleic diamide, maleic N-monoethylamide, maleic N,N-diethylamide, maleic N-monobutylamide, maleic N,N dibutylamide, fumaric monoamide, fumaric diamide, fumaric N-monoethylamide, fumaric N,N-diethylamide, fumaric N-monobutylamide and fumaric N,N-dibutylamide, imide derivatives of unsaturated carboxylic acids including maleimide, N-butylmaleimide and N-phenylmaleimide; and metal salts of unsaturated carboxylic acids including sodium acrylate, sodium methacrylate, potassium acrylate or potassium methacrylate.
44. The closure of claim 43 wherein the modifying group is a fused ring carboxylic acid anhydride.
45. A closure assembly comprising:
a transfer tubing having a multiple layered structure having a first layer of an ethylene vinyl alcohol copolymer and a second layer of a polyolefin, the tubing defining a fluid passageway, the tubing having an end surface; and
a membrane material having a first layer of an ethylene vinyl alcohol copolymer and a second layer of a modified ethylene vinyl acetate copolymer, the membrane material disposed across the fluid passageway to provide a fluid tight seal.
46. The closure of claim 45 wherein the membrane material is attached to the end surface of the tubing.
47. A closure assembly comprising:
a transfer tubing having a first layer of an ethylene vinyl alcohol copolymer, a second layer of a polyolefin and a third layer selected from the group consisting of polyamides and polyesters, the tubing defining a fluid passageway, the tubing having an end surface; and
a membrane material having a first layer of an ethylene vinyl alcohol copolymer, a second layer of a modified ethylene vinyl acetate copolymer and a third layer selected from the group of polyamides and polyesters, the membrane material being disposed across the fluid passageway to provide a fluid tight seal.
48. The closure of claim 47 wherein the membrane material is attached to the end surface of the tubing.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A method of forming a non-planar quantum well structure, comprising:
providing a quantum well structure having a substrate, at least one of a IV and III-V material barrier layer, and a quantum well layer that includes a channel region;
selectively etching the quantum well structure to form a fin structure that is (a) formed in the quantum well structure, and (b) includes the quantum well layer;
providing a high-k dielectric layer over the fin structure; and
providing gate metal over the high-k dielectric layer.
2. The method of claim 1, wherein the quantum well layer includes germanium.
3. The method of claim 1 comprising:
providing an interfacial layer over the fin structure, a material of the interfacial layer having a higher bandgap than a bandgap of a material of the fin structure; and
providing an intermediate layer over the interfacial layer prior to providing the high-k dielectric layer.
4. The method of claim 3, wherein the interfacial layer comprises epitaxially grown silicon.
5. The method of claim 3, wherein the intermediate layer comprises a dielectric material different from a material of the high-k dielectric layer.
6. A non-planar quantum well device, comprising:
a quantum well structure having a substrate, at least one of a IV and III-V material barrier layer, and a quantum well layer that includes a channel region;
a fin structure that (a) is formed in the quantum well structure and, (b) includes the quantum well layer;
a high-k layer over the fin structure; and
a gate metal over the high-k layer.
7. The device of claim 6, wherein the quantum well layer includes germanium.
8. The device of claim 6 comprising an intermediate layer between an interfacial layer and the high-k layer.
9. The device of claim 6 comprising an interfacial layer that covers a 100 surface and a 110 surface of the fin structure.
10. The device of claim 6 comprising an interfacial layer, over the fin structure, which comprises silicon.
11. The device of claim 10, wherein the silicon is epitaxial.
12. The device of claim 6, comprising an interfacial layer, over the fin structure, which comprises a single monolayer of atoms.
13. The device of claim 8, wherein the intermediate layer comprises a dielectric material different from a material of the high-k layer.
14. The device of claim 13, wherein the intermediate layer comprises at least one of silicon dioxide, alumina, zirconia and hafnium silicate.
15. The device of claim 8, wherein the intermediate layer includes a material obtained from an oxidization of a surface of the interfacial layer.
16. The device of claim 6 comprising drain and source regions at respective ends of the fin structure.
17. The device of claim 6, wherein the quantum well structure further includes a doping layer.
18. The device of claim 6, wherein the quantum well layer is epitaxial.
19. A system comprising:
a processor including:
a quantum well structure having a substrate, at least one of a IV and III-V material barrier layer, and a quantum well layer that includes a channel region;
a fin structure that (a) is formed in the quantum well structure and, (b) includes the quantum well layer;
a high-k layer provided over the fin structure; and
a gate metal over the high-k layer; and

a memory coupled to the processor.
20. The system of claim 19 comprising an interfacial layer over the fin structure; wherein (a) the interfacial layer comprises epitaxial silicon, and (b) the quantum well structure includes an intermediate layer, included between the interfacial layer and the high-k layer, that comprises silicon dioxide.